ID A0A401PQP3_SCYTO Unreviewed; 718 AA.
AC A0A401PQP3;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=VWFD domain-containing protein {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=scyTo_0020913 {ECO:0000313|EMBL:GCB75446.1};
OS Scyliorhinus torazame (Cloudy catshark).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Galeomorphii; Galeoidea; Carcharhiniformes; Scyliorhinidae;
OC Scyliorhinus.
OX NCBI_TaxID=75743 {ECO:0000313|EMBL:GCB75446.1, ECO:0000313|Proteomes:UP000288216};
RN [1] {ECO:0000313|EMBL:GCB75446.1, ECO:0000313|Proteomes:UP000288216}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=30297745; DOI=.1038/s41559-018-0673-5;
RA Hara Y, Yamaguchi K, Onimaru K, Kadota M, Koyanagi M, Keeley SD, Tatsumi K,
RA Tanaka K, Motone F, Kageyama Y, Nozu R, Adachi N, Nishimura O, Nakagawa R,
RA Tanegashima C, Kiyatake I, Matsumoto R, Murakumo K, Nishida K, Terakita A,
RA Kuratani S, Sato K, Hyodo S Kuraku.S.;
RT "Shark genomes provide insights into elasmobranch evolution and the origin
RT of vertebrates.";
RL Nat. Ecol. Evol. 2:1761-1771(2018).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00039}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GCB75446.1}.
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DR EMBL; BFAA01017639; GCB75446.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A401PQP3; -.
DR STRING; 75743.A0A401PQP3; -.
DR OMA; EKWECDC; -.
DR Proteomes; UP000288216; Unassembled WGS sequence.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR036084; Ser_inhib-like_sf.
DR InterPro; IPR014853; VWF/SSPO/ZAN-like_Cys-rich_dom.
DR InterPro; IPR001846; VWF_type-D.
DR InterPro; IPR025155; WxxW_domain.
DR PANTHER; PTHR11339; EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED; 1.
DR PANTHER; PTHR11339:SF398; MUCIN-2-LIKE-RELATED; 1.
DR Pfam; PF08742; C8; 1.
DR Pfam; PF13330; Mucin2_WxxW; 1.
DR Pfam; PF00094; VWD; 1.
DR SMART; SM00832; C8; 1.
DR SMART; SM00041; CT; 1.
DR SMART; SM00216; VWD; 1.
DR SUPFAM; SSF57567; Serine protease inhibitors; 1.
DR PROSITE; PS01225; CTCK_2; 1.
DR PROSITE; PS51233; VWFD; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00039}; Reference proteome {ECO:0000313|Proteomes:UP000288216};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 308..487
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 633..718
FT /note="CTCK"
FT /evidence="ECO:0000259|PROSITE:PS01225"
FT REGION 44..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 633..683
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00039"
FT DISULFID 659..713
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00039"
FT DISULFID 663..715
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00039"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:GCB75446.1"
SQ SEQUENCE 718 AA; 79643 MW; 82D5CC697BA3B303 CRC64;
DCVSYSPEVT TTTVTPTTTA STTISTPEVT PTTKVTTVSI ARSTTAVPPT TQETSTTPGK
TITTEGVTTT VKSTTTESTT GSTLEVTTTT VTSTTRSSTP EVTTTKELTT VSAVSTTTVV
CNGVWSDWLN ENTPSIPNKN DVELLKPIRE KQCPVATHKV SQIECEAVKF PQRPIGESKD
NVTCDVEKGL ICTFDEETSQ KNIMCLDYRI RVCCESVTST TPSTVSPTTA ISSTTREPGC
YCNQVPRRKC NETWVDHCSK FTCLGGDTYL MKNITCPSLP SKPECRHGLE PVKVQTKNGC
CEKWECDCQC EVWGEPHYRT FDDLQYDFFE NCTYILVEEK VPKYNLKILV DNYFCLPSIP
KSCPKGLVVS YNGIDVTIST GDEYVLTVNK KEVSLPYSAN GFEITKLGTI TYISIPDIRT
SITALRNAFR IRVPEQFFLD NTQGQCGSCS NSLSNCTRKN GKVESLDCCS QTAYDWRVYD
PKKPYCQLPP PDVPCTPTTP APTCKPEETI CDIIAEKPFE ECSKKIDLGK YIKTCHFDHC
QLNSTVDCSS LEAAAMACAS IGICVNWRPF TNEKCNYSCD RDLVYNFCRK KEDDSCVNQL
VIPGRKYPAA MEGCFCPDGM MLAENNTKCI ATCDVCKPTL HMEIIVKDDC EANVKVNQCE
GTCFSMTKYN FDINALQHIC QCCRARETEE KSVKLQCKNG TTKTYKYTDI KSCICQKT
//
