ID A0A401PQZ1_SCYTO Unreviewed; 987 AA.
AC A0A401PQZ1;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=FCS-type domain-containing protein {ECO:0000259|PROSITE:PS51024};
DE Flags: Fragment;
GN ORFNames=scyTo_0016434 {ECO:0000313|EMBL:GCB75533.1};
OS Scyliorhinus torazame (Cloudy catshark).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Galeomorphii; Galeoidea; Carcharhiniformes; Scyliorhinidae;
OC Scyliorhinus.
OX NCBI_TaxID=75743 {ECO:0000313|EMBL:GCB75533.1, ECO:0000313|Proteomes:UP000288216};
RN [1] {ECO:0000313|EMBL:GCB75533.1, ECO:0000313|Proteomes:UP000288216}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=30297745; DOI=.1038/s41559-018-0673-5;
RA Hara Y, Yamaguchi K, Onimaru K, Kadota M, Koyanagi M, Keeley SD, Tatsumi K,
RA Tanaka K, Motone F, Kageyama Y, Nozu R, Adachi N, Nishimura O, Nakagawa R,
RA Tanegashima C, Kiyatake I, Matsumoto R, Murakumo K, Nishida K, Terakita A,
RA Kuratani S, Sato K, Hyodo S Kuraku.S.;
RT "Shark genomes provide insights into elasmobranch evolution and the origin
RT of vertebrates.";
RL Nat. Ecol. Evol. 2:1761-1771(2018).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GCB75533.1}.
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DR EMBL; BFAA01009925; GCB75533.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A401PQZ1; -.
DR STRING; 75743.A0A401PQZ1; -.
DR Proteomes; UP000288216; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 2.30.30.140; -; 2.
DR Gene3D; 3.30.60.160; -; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR InterPro; IPR004092; Mbt.
DR InterPro; IPR012313; Znf_FCS.
DR InterPro; IPR038603; Znf_FCS_sf.
DR PANTHER; PTHR24373:SF284; CHONDROADHERIN-LIKE PROTEIN; 1.
DR PANTHER; PTHR24373; SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN; 1.
DR Pfam; PF13855; LRR_8; 4.
DR Pfam; PF02820; MBT; 1.
DR Pfam; PF21319; zf-FCS_1; 1.
DR SMART; SM00369; LRR_TYP; 14.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00013; LRRNT; 2.
DR SMART; SM00561; MBT; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 2.
DR PROSITE; PS51450; LRR; 2.
DR PROSITE; PS51079; MBT; 2.
DR PROSITE; PS51024; ZF_FCS; 1.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00367};
KW Reference proteome {ECO:0000313|Proteomes:UP000288216};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00367};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00367}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..987
FT /note="FCS-type domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019074313"
FT DOMAIN 683..718
FT /note="FCS-type"
FT /evidence="ECO:0000259|PROSITE:PS51024"
FT REPEAT 780..884
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REPEAT 892..987
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REGION 640..666
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 987
FT /evidence="ECO:0000313|EMBL:GCB75533.1"
SQ SEQUENCE 987 AA; 111063 MW; 4D2014E6657BA386 CRC64;
MLSPCSSHWL LGAVFTTLVV GALACPPYCI CDNIQRVVTC IKKELTEVPI TIPEATKKLD
IKGNNINMIP NGAFLPIPYL THLNLQKCKI HHLAEGAFRG LGQLTYLNLG FNNIEFIYQE
TFDGLMSLQQ LIIDNNRIEE IKPGAFSQLG FLNFLNLEGN LLVYLPPLVF QGLQQIKHLR
LSKNMLNNIA DEALAGLWAL KRLSLDGNEL QYLPTEALSR LKNVARLDLG RNPMTYLGEE
SIRVHSLKHL ALDNMALQEV SHSAFVHSPQ LTVIDLRYNQ LQIMQPPEGV ESLRMINLTG
NPIQCNCLMR PFREWMAGHA KPKAEVFCGA PAVFRGERLD SLRLVDLKCI SHPSDYEDEE
ELKLENQPDT NNQENLPCPE HCDCKHDLKH SSCEGKGLRK IPKGFPIDAQ LLDMRYNDFY
LVPKGSFPDL KKLVSLHMQK CRIHDIHAGA FRGLKKLIYL YLSGNEISSL EPEIFDGLPD
LTYLYLDYNR LSLIPKGAFK LLPDLFALHL EYNPIPRLTD DNMEGAGQIR WLYLTGNNIT
YISPTALQPV GELQKLFLDE NKLTAVPTIA LTGMPILDEL RLSNNPIKQI GDAAFLPLAG
SLQHLWLSDM GLEKKVLEMS FKGGGAIDYG LFDGFDSMED PGSSSNDNFT EESSNDMEDE
DSGQQMDVES GSMLGVMGDD ESIDEKLGMA TCEMCGIVGA RDTFFSKTKR FCSVSCSRSY
SSNSKKASIL ARLQGKPPTK KAKVLNKASW VSKLGAFLHQ TSGEVRHGNH NSNSAGGQSF
EWGKYIEKHK YNAAPVSCFK HVPLFDQWED VLEGMKVEIL NLDYNLPNKV YWIAYVIKLA
GYKAMLRYEG FENNARHDFW YNLGTADVHP IGWCATFGKP LVPPQTVRNR TTDWRNYLLK
KLIGSKTLPV DFHYKLGAYT FTSRIGTTRA DLSSHPTFRK IYCDAVPHLF KKVRAVYTND
DWFEEGMKLE AIDPLNLSTI CVASVQK
//
