ID A0A401PUY6_SCYTO Unreviewed; 640 AA.
AC A0A401PUY6;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE RecName: Full=Alpha-2-macroglobulin bait region domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=scyTo_0019946 {ECO:0000313|EMBL:GCB76941.1};
OS Scyliorhinus torazame (Cloudy catshark).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Galeomorphii; Galeoidea; Carcharhiniformes; Scyliorhinidae;
OC Scyliorhinus.
OX NCBI_TaxID=75743 {ECO:0000313|EMBL:GCB76941.1, ECO:0000313|Proteomes:UP000288216};
RN [1] {ECO:0000313|EMBL:GCB76941.1, ECO:0000313|Proteomes:UP000288216}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=30297745; DOI=.1038/s41559-018-0673-5;
RA Hara Y, Yamaguchi K, Onimaru K, Kadota M, Koyanagi M, Keeley SD, Tatsumi K,
RA Tanaka K, Motone F, Kageyama Y, Nozu R, Adachi N, Nishimura O, Nakagawa R,
RA Tanegashima C, Kiyatake I, Matsumoto R, Murakumo K, Nishida K, Terakita A,
RA Kuratani S, Sato K, Hyodo S Kuraku.S.;
RT "Shark genomes provide insights into elasmobranch evolution and the origin
RT of vertebrates.";
RL Nat. Ecol. Evol. 2:1761-1771(2018).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GCB76941.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BFAA01015392; GCB76941.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A401PUY6; -.
DR STRING; 75743.A0A401PUY6; -.
DR OMA; KSHEEHY; -.
DR Proteomes; UP000288216; Unassembled WGS sequence.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR Gene3D; 2.20.130.20; -; 1.
DR Gene3D; 2.60.40.1930; -; 2.
DR Gene3D; 6.20.50.160; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR001599; Macroglobln_a2.
DR PANTHER; PTHR11412:SF139; C3 AND PZP-LIKE ALPHA-2-MACROGLOBULIN DOMAIN-CONTAINING PROTEIN 8; 1.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SUPFAM; SSF81296; E set domains; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000288216}.
FT DOMAIN 97..265
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 391..482
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
FT REGION 141..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 640 AA; 71499 MW; 2BD10202CE66917D CRC64;
MLVLFSQVEV MYPDGSPANG ITVRIKAELT PKDNVYTSEL VSENSRVEFE IPSIPTAAQY
VWLETKVTAI NGTPAGDQYL PSYLSISSWY SPSKCHIQLQ GPDRAFRVGE EAQIALKSTC
SCDFTLHYEL ASRGNIVKTG RQPASVTRQR SKRATVTFDK EKQPAQNYQS KSSASEVDVC
STSLGFTVTY DMIPLSRLLV FYVRENGEGI TDSIQIPVQP TYQNKVSISL SANKTMPGDL
ISVAVKGEAR SCVCVASVDK SVYLLKPGFQ LTTEKVFQEL ANYDVSDAFG IPKDDGHFWW
PGLSSRRRRK RRSSVFPWHW DITKDAHFAF SETGLVVMTD IVSLNHRQNG GMYTDEAVPA
FQPHTGSLVA ALHPRTLPRV EKRKRTYFPE TWIWHCLNIS DSTGEARLHV EVPDSITTWV
TEAVSLSQEH GLGLAKSTEL RTFKPFFVDF TLPYHVIRGE QTKLPLIIYN YLPSCAEVHV
KITVPKGIKF IGHQGKRHLT RKMCVSSEEA KPTSIVLSFS ELGPANITAK AFAYSESSCC
EGGLQTLKNS KYLDDGYMDR RTPASVDYVK RLVLVEPEGL PREYTYSIFF CPNGWARYDA
IQGIFDCGVG DIQVPGDQLH RLLNRLGLDG RVQNLEKGGI
//
