ID A0A401PVR9_SCYTO Unreviewed; 730 AA.
AC A0A401PVR9;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Heat shock protein HSP 90-alpha {ECO:0000256|ARBA:ARBA00039928};
GN ORFNames=scyTo_0021072 {ECO:0000313|EMBL:GCB77163.1};
OS Scyliorhinus torazame (Cloudy catshark).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Galeomorphii; Galeoidea; Carcharhiniformes; Scyliorhinidae;
OC Scyliorhinus.
OX NCBI_TaxID=75743 {ECO:0000313|EMBL:GCB77163.1, ECO:0000313|Proteomes:UP000288216};
RN [1] {ECO:0000313|EMBL:GCB77163.1, ECO:0000313|Proteomes:UP000288216}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=30297745; DOI=.1038/s41559-018-0673-5;
RA Hara Y, Yamaguchi K, Onimaru K, Kadota M, Koyanagi M, Keeley SD, Tatsumi K,
RA Tanaka K, Motone F, Kageyama Y, Nozu R, Adachi N, Nishimura O, Nakagawa R,
RA Tanegashima C, Kiyatake I, Matsumoto R, Murakumo K, Nishida K, Terakita A,
RA Kuratani S, Sato K, Hyodo S Kuraku.S.;
RT "Shark genomes provide insights into elasmobranch evolution and the origin
RT of vertebrates.";
RL Nat. Ecol. Evol. 2:1761-1771(2018).
CC -!- SIMILARITY: Belongs to the heat shock protein 90 family.
CC {ECO:0000256|ARBA:ARBA00008239}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GCB77163.1}.
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DR EMBL; BFAA01018043; GCB77163.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A401PVR9; -.
DR STRING; 75743.A0A401PVR9; -.
DR OMA; DAQTHAN; -.
DR Proteomes; UP000288216; Unassembled WGS sequence.
DR GO; GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR CDD; cd16927; HATPase_Hsp90-like; 1.
DR Gene3D; 3.30.230.80; -; 1.
DR Gene3D; 3.40.50.11260; -; 1.
DR Gene3D; 1.20.120.790; Heat shock protein 90, C-terminal domain; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR HAMAP; MF_00505; HSP90; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR019805; Heat_shock_protein_90_CS.
DR InterPro; IPR037196; HSP90_C.
DR InterPro; IPR001404; Hsp90_fam.
DR InterPro; IPR020575; Hsp90_N.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR PANTHER; PTHR11528; HEAT SHOCK PROTEIN 90 FAMILY MEMBER; 1.
DR PANTHER; PTHR11528:SF87; HEAT SHOCK PROTEIN HSP 90-ALPHA; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF00183; HSP90; 1.
DR PIRSF; PIRSF002583; Hsp90; 1.
DR PRINTS; PR00775; HEATSHOCK90.
DR SMART; SM00387; HATPase_c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF110942; HSP90 C-terminal domain; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00298; HSP90; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000288216}.
FT DOMAIN 41..195
FT /note="Histidine kinase/HSP90-like ATPase"
FT /evidence="ECO:0000259|SMART:SM00387"
FT REGION 228..275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 697..730
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 714..730
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 730 AA; 84304 MW; AD6EF2ECD0D9A1FE CRC64;
MPEETPVAMQ DMPMEEDTET FAFQAEIAQL MSLIINTFYS NKEIFLRELI SNSSDALDKI
RYESLTDPSK LDSGKELKVD IIPDHKLRTL TLQDTGIGMT KADLINNLGT IAKSGTKAFM
EALQAGADIS MIGQFGVGFY SAYLVAEKVT VITKHNDDDQ YVWESSAGGS FTVRLDHGEE
IGRGTRVILH LKEDQMEYIE EKRVKEIVKK HSQFIGYPIT LFVEKERDKE ISDDEGEEKE
EKKEDAAEED DKPKIEDVGS DEEEDEKKGD KKKKRKIKEK YIDQEELNKT KPIWTRNPED
ITNEEYGEFY KSLTNDWEEH LAVKHFSVEG QLEFRALLFA PRRAPFDLFE NRKKKNNIKL
YVRRVFIMDN CEELIPEYLN FIKGVVDSED LPLNISREML QQSKILKVIR KNLVKKCLEL
FIELSEDQEN YKKLYEQFSK NLKLGIHEDS QNRKKLSELL RYHTSVTGDE MVSLKDYVSR
MKDHQKHIYY ITGETKDQVA NSAFVERLRK HGLEVIYMTE PIDEYCVQQL KEFDGKTLVS
VTKEGLELPE DEEEKKKQEE KKANFENLCK IMKDILEKKI EKVTVSNRLV ASPCCIVTST
YGWTANMERI MKAQALRDNS TMGYMAAKKH LEINPDHPIV ETLRQKAEAD KNDKSVKDLV
ILLFETALLS SGFSLEDPQT HANRIYRMIK LGLGIDEEDP VMEDAGPTNT EEMPPLEGDD
DDTSRMEEVD
//