ID A0A401QC23_SCYTO Unreviewed; 378 AA.
AC A0A401QC23;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE RecName: Full=Zinc transporter ZIP6 {ECO:0000256|ARBA:ARBA00039393};
DE AltName: Full=Solute carrier family 39 member 6 {ECO:0000256|ARBA:ARBA00042779};
DE AltName: Full=Zrt- and Irt-like protein 6 {ECO:0000256|ARBA:ARBA00041704};
DE Flags: Fragment;
GN ORFNames=scyTo_0023509 {ECO:0000313|EMBL:GCB82924.1};
OS Scyliorhinus torazame (Cloudy catshark).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Galeomorphii; Galeoidea; Carcharhiniformes; Scyliorhinidae;
OC Scyliorhinus.
OX NCBI_TaxID=75743 {ECO:0000313|EMBL:GCB82924.1, ECO:0000313|Proteomes:UP000288216};
RN [1] {ECO:0000313|EMBL:GCB82924.1, ECO:0000313|Proteomes:UP000288216}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=30297745; DOI=.1038/s41559-018-0673-5;
RA Hara Y, Yamaguchi K, Onimaru K, Kadota M, Koyanagi M, Keeley SD, Tatsumi K,
RA Tanaka K, Motone F, Kageyama Y, Nozu R, Adachi N, Nishimura O, Nakagawa R,
RA Tanegashima C, Kiyatake I, Matsumoto R, Murakumo K, Nishida K, Terakita A,
RA Kuratani S, Sato K, Hyodo S Kuraku.S.;
RT "Shark genomes provide insights into elasmobranch evolution and the origin
RT of vertebrates.";
RL Nat. Ecol. Evol. 2:1761-1771(2018).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Zn(2+)(in) = Zn(2+)(out); Xref=Rhea:RHEA:29351,
CC ChEBI:CHEBI:29105; Evidence={ECO:0000256|ARBA:ARBA00034634};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC {ECO:0000256|ARBA:ARBA00006939}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GCB82924.1}.
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DR EMBL; BFAA01030070; GCB82924.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A401QC23; -.
DR STRING; 75743.A0A401QC23; -.
DR Proteomes; UP000288216; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046873; F:metal ion transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR003689; ZIP.
DR PANTHER; PTHR12191; SOLUTE CARRIER FAMILY 39; 1.
DR PANTHER; PTHR12191:SF22; ZINC TRANSPORTER ZIP6; 1.
DR Pfam; PF02535; Zip; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000288216};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 320..342
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 354..376
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 155..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 223..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 164..182
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 234..261
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 378
FT /evidence="ECO:0000313|EMBL:GCB82924.1"
SQ SEQUENCE 378 AA; 41525 MW; 41AFEC5528C5BA5C CRC64;
MLVKSGVKSF GMTPVVRYPP LRLFLTCLVV FFRNGYCGHA DHDTECTVLG EHDHPPQLDA
ITTSMDRNRA EFEQNYYLHK LFDQYGENGT LTVEGLEKLL CNIGVGGVRT MRTKHEHFDH
VTKKHLVLAE GSIHRHCCPE CQHIRVTIGL ETTSKETENF PKHSHPSGQH TSGTTPPSIT
PAGDKSETRR HTRPARSPVS AIPAVADTHL TAGLKAELVT TGGYGTDTAD QPPTEYSTHK
DGKAAQRRNN PLENHTDKHT KGEECLNADN LLSSHGMTPQ TTLNAEQFGY ICPALLDQIE
SKACITHETR EKRTASSSAG AAWIGGFVSV TVISLLSLLG VIFMPLMNKI FFKFLLTFLV
ALAVGTLSGD AFLHLLPH
//
