ID A0A401RFN1_CHIPU Unreviewed; 1092 AA.
AC A0A401RFN1;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=USP domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=chiPu_0017401 {ECO:0000313|EMBL:GCC16953.1};
OS Chiloscyllium punctatum (Brownbanded bambooshark) (Hemiscyllium punctatum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Galeomorphii; Galeoidea; Orectolobiformes; Hemiscylliidae;
OC Chiloscyllium.
OX NCBI_TaxID=137246 {ECO:0000313|EMBL:GCC16953.1, ECO:0000313|Proteomes:UP000287033};
RN [1] {ECO:0000313|EMBL:GCC16953.1, ECO:0000313|Proteomes:UP000287033}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=30297745; DOI=.1038/s41559-018-0673-5;
RA Hara Y, Yamaguchi K, Onimaru K, Kadota M, Koyanagi M, Keeley SD, Tatsumi K,
RA Tanaka K, Motone F, Kageyama Y, Nozu R, Adachi N, Nishimura O, Nakagawa R,
RA Tanegashima C, Kiyatake I, Matsumoto R, Murakumo K, Nishida K, Terakita A,
RA Kuratani S, Sato K, Hyodo S Kuraku.S.;
RT "Shark genomes provide insights into elasmobranch evolution and the origin
RT of vertebrates.";
RL Nat. Ecol. Evol. 2:1761-1771(2018).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GCC16953.1}.
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DR EMBL; BEZZ01001278; GCC16953.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A401RFN1; -.
DR STRING; 137246.A0A401RFN1; -.
DR OMA; TCNKESA; -.
DR Proteomes; UP000287033; Unassembled WGS sequence.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:InterPro.
DR GO; GO:0019538; P:protein metabolic process; IEA:UniProt.
DR CDD; cd02674; Peptidase_C19R; 1.
DR CDD; cd22265; UDM1_RNF168; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR Gene3D; 1.20.58.80; Phosphotransferase system, lactose/cellobiose-type IIA subunit; 1.
DR Gene3D; 3.40.250.10; Rhodanese-like domain; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR001763; Rhodanese-like_dom.
DR InterPro; IPR036873; Rhodanese-like_dom_sf.
DR InterPro; IPR015063; USP8_dimer.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR InterPro; IPR048498; WW_USP8.
DR PANTHER; PTHR21646; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR21646:SF27; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 8; 1.
DR Pfam; PF00443; UCH; 1.
DR Pfam; PF08969; USP8_dimer; 1.
DR Pfam; PF20625; WW_USP8; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF52821; Rhodanese/Cell cycle control phosphatase; 1.
DR SUPFAM; SSF140856; USP8 N-terminal domain-like; 1.
DR PROSITE; PS50206; RHODANESE_3; 1.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000287033}.
FT DOMAIN 201..323
FT /note="Rhodanese"
FT /evidence="ECO:0000259|PROSITE:PS50206"
FT DOMAIN 752..1083
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 124..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 417..624
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 124..144
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 419..435
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 467..592
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 600..617
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1092 AA; 125429 MW; 3B0D80486ADBC650 CRC64;
MPAVSSDLKE LYLSTCLADL NKKAEVKLET KSTKNYVTSA CKIFKAAEEC RLDRDEEKAY
VLYMKYLTVY DLIRKRTDFK HQQDYYLSLL GPANFRKAIE EAERLSESLK LRYEEAEVRK
KLEENERLQE EKRKQQEEAK SKGYDNNLKT TTKSSSDCFG IKKRNLKEDF EVNDKKTHSE
CNDSLQGAVT AEKLFAMMQD ENTEMIIMDA RSSKDYQDSH MQVARSHCIS VPEEAVSPGI
TVNQIELKLP EESKEIWQKR QFVDYIILLD WDSSVHQVKR GTILQSLKDA LYKWDSQIIL
RSEPLVLEGG YDSWLLCYPM YTTNAKVTVP KKEPPGAVQV SLNFSYPSLE EPPQPSKDLN
ESKAVQELEI FNEHLSLLEE TPKKVNLKTI NVPNGILAPG VPVTGQPVAM KTIPQIDRTK
KPSLKQSNRS LSKSEVVGAD SLPVHNGPVI PDRSTKPCIE SQNSLTDEER NQIHAEAALI
GEKARKEREQ RERRQEEERK EKERLERLRE EERREKEQCE EEEKEFKTKA DQEREPKENE
EQRAQEIEDN QQKEEAERKG LAEQKKTSPE KGKIESQIRD QADTRKSGEQ SVSELEGLRG
TNLEKQEHRD TLTRARSEEM GRTVPGLPQG WMKFLDVVTG TYRYYHSPTN SVHMYPPEMV
PSITPPATPP THKAKPQTAK DVDVPKLKRS FSSPDIAQAI QEEQNKATTK IVPTVNRETK
PSGYSKTEIS SPSASQIRNL NPVYGGMGRA LTGLRNLGNT CYMNSILQCL SNTPHLAEYF
NKNFYQQDIN RSNILGHKGE VAEEFGVIMK SLWSGQYKYI SPRDFKGRIG KINDTFAGYV
QQDSQELLLF LMDGLHEDLN KADRKRYKEE NTDSLDDTRA ADLAWQKHKL LNESIIVALF
QGQFKSTVQC LTCHKRSRTF EAFMYLSLPL PSSSKCSLQD CLKLFSKEEK LTDNNRFHCS
NCKAHRDSTK KLEIWKLPPI LLVHLKRFSY EGRWKQKLQT NVDFPLENLD LFSYLIGPRS
NVKRYNLFAV SNHYGGLDGG HYTAYCKNAV KQRWFKFDDQ DVSEISPSSV RSPAAYILFY
SSLELRVVDL AT
//
