ID A0A401RHJ0_CHIPU Unreviewed; 481 AA.
AC A0A401RHJ0;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=THUMP domain-containing protein {ECO:0000259|PROSITE:PS51165};
DE Flags: Fragment;
GN ORFNames=chiPu_0017624 {ECO:0000313|EMBL:GCC17615.1};
OS Chiloscyllium punctatum (Brownbanded bambooshark) (Hemiscyllium punctatum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Galeomorphii; Galeoidea; Orectolobiformes; Hemiscylliidae;
OC Chiloscyllium.
OX NCBI_TaxID=137246 {ECO:0000313|EMBL:GCC17615.1, ECO:0000313|Proteomes:UP000287033};
RN [1] {ECO:0000313|EMBL:GCC17615.1, ECO:0000313|Proteomes:UP000287033}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=30297745; DOI=.1038/s41559-018-0673-5;
RA Hara Y, Yamaguchi K, Onimaru K, Kadota M, Koyanagi M, Keeley SD, Tatsumi K,
RA Tanaka K, Motone F, Kageyama Y, Nozu R, Adachi N, Nishimura O, Nakagawa R,
RA Tanegashima C, Kiyatake I, Matsumoto R, Murakumo K, Nishida K, Terakita A,
RA Kuratani S, Sato K, Hyodo S Kuraku.S.;
RT "Shark genomes provide insights into elasmobranch evolution and the origin
RT of vertebrates.";
RL Nat. Ecol. Evol. 2:1761-1771(2018).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily.
CC {ECO:0000256|ARBA:ARBA00008361}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GCC17615.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BEZZ01001331; GCC17615.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A401RHJ0; -.
DR STRING; 137246.A0A401RHJ0; -.
DR OMA; TQDRKCF; -.
DR Proteomes; UP000287033; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0009451; P:RNA modification; IEA:UniProt.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 3.30.2130.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR000241; RlmKL-like_Mtase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR004114; THUMP_dom.
DR PANTHER; PTHR14911; THUMP DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR14911:SF13; TRNA (GUANINE(6)-N2)-METHYLTRANSFERASE THUMP3; 1.
DR Pfam; PF02926; THUMP; 1.
DR Pfam; PF01170; UPF0020; 1.
DR SMART; SM00981; THUMP; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF143437; THUMP domain-like; 1.
DR PROSITE; PS51165; THUMP; 1.
DR PROSITE; PS01261; UPF0020; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000287033};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00529};
KW Transferase {ECO:0000256|ARBA:ARBA00022603}.
FT DOMAIN 149..254
FT /note="THUMP"
FT /evidence="ECO:0000259|PROSITE:PS51165"
FT REGION 86..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:GCC17615.1"
SQ SEQUENCE 481 AA; 53720 MW; DAB5CB6E50B04924 CRC64;
VLEKIGSESR ISKDRGKIYF EVSTDNLFQI HLLRSVDNLF VVIQEFPHYQ FGETKESVLE
DFRQLAPQLL WDCPLKVWEL NNSLKKRKGQ RRKGSRGCGL GPEASRETGK IKVGQREPAP
SDQSATNDPA HLGTELPIIL SGASGDQPDE IEETSDAVAP GVVLSDQAKI SPEGLLSDND
SRPAASEDEG KGLRRFRVTC NRSGEKHNFT SMEAAREFGG AVQDFFKWKA DMTKFDVEIL
LNIHDNEVVV AIALTEESLH KRNITHFGPT TLRSTLAYGM LRLCKPQPTD IIVDPMCGTG
AIPIEGALEF SQCYFLAGDN NILAVNRSVN NINSLQKKRL EKGRVTWGMP LDVVQWDICN
LPLKTSSVDV IISDMPFGKR IGSRRKNWDL YPACLQEMGR VCRPETGRAA LLTQDKKCFV
KAMSRMGHLW RKSHTVWVNV GGLHAAVYLL KRTSLSLDRL FQRPRDSATS EEIPCKTGAK
E
//
