ID A0A401RPU5_CHIPU Unreviewed; 770 AA.
AC A0A401RPU5;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=VWFA domain-containing protein {ECO:0000259|PROSITE:PS50234};
GN ORFNames=chiPu_0018801 {ECO:0000313|EMBL:GCC20197.1};
OS Chiloscyllium punctatum (Brownbanded bambooshark) (Hemiscyllium punctatum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Galeomorphii; Galeoidea; Orectolobiformes; Hemiscylliidae;
OC Chiloscyllium.
OX NCBI_TaxID=137246 {ECO:0000313|EMBL:GCC20197.1, ECO:0000313|Proteomes:UP000287033};
RN [1] {ECO:0000313|EMBL:GCC20197.1, ECO:0000313|Proteomes:UP000287033}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=30297745; DOI=.1038/s41559-018-0673-5;
RA Hara Y, Yamaguchi K, Onimaru K, Kadota M, Koyanagi M, Keeley SD, Tatsumi K,
RA Tanaka K, Motone F, Kageyama Y, Nozu R, Adachi N, Nishimura O, Nakagawa R,
RA Tanegashima C, Kiyatake I, Matsumoto R, Murakumo K, Nishida K, Terakita A,
RA Kuratani S, Sato K, Hyodo S Kuraku.S.;
RT "Shark genomes provide insights into elasmobranch evolution and the origin
RT of vertebrates.";
RL Nat. Ecol. Evol. 2:1761-1771(2018).
CC -!- SIMILARITY: Belongs to the CLCR family.
CC {ECO:0000256|ARBA:ARBA00006398}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GCC20197.1}.
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DR EMBL; BEZZ01001698; GCC20197.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A401RPU5; -.
DR STRING; 137246.A0A401RPU5; -.
DR OMA; QAIHETN; -.
DR Proteomes; UP000287033; Unassembled WGS sequence.
DR GO; GO:0005229; F:intracellular calcium activated chloride channel activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00198; vWFA; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR004727; CLCA_chordata.
DR InterPro; IPR013642; CLCA_N.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR NCBIfam; NF041940; choice_anch_X; 1.
DR NCBIfam; TIGR00868; hCaCC; 1.
DR PANTHER; PTHR10579; CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR; 1.
DR PANTHER; PTHR10579:SF43; LOW QUALITY PROTEIN: EPITHELIAL CHLORIDE CHANNEL PROTEIN-LIKE ISOFORM X1-RELATED; 1.
DR Pfam; PF08434; CLCA; 1.
DR Pfam; PF13519; VWA_2; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00023049};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00023049};
KW Reference proteome {ECO:0000313|Proteomes:UP000287033};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transport {ECO:0000256|ARBA:ARBA00022448};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 290..460
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
SQ SEQUENCE 770 AA; 84565 MW; D725022E60CEF72B CRC64;
MEALTPECTG IKLENNGYRD IVIAINPKVQ HNEQLIQNIQ EMVTAASSYL HQATKERVYF
ADVKILLPIT WPVGSHTVRR RTTESYEKAD VIIEEPYRKY GDEPYTLQYG GCGEKGRYIH
FTPNFILDSR LVSVYGPKDR VFVHEWAHLQ WGVFDEYNER VPFYLFNGTS EATRCSKEIR
GRAAEHKNGS FSACETDPKS GLPKRDCKFH PDINQIVSSS IMFIQALSSV TEFCDDKTHN
PDAPNMQNKM CNFRSTWDVI SKSEDFRNNP SPYSGSVIPT FTLLQAKHRV VCLVLDVSGS
MDSENRINRL RQAAEIFLLQ IIEAKSQVGI VTFNSAATIQ SHLKVIDNEG VRNQLVQLLP
TTANGGTNIC AGVQTGFQVL GDDDGATNGG EIVLLTDGED SGISSCFSEV ERSGAVIHTI
ALGPDAAAEL EQMSTLTGGR QFAATDKVDA TGLSDAFSSI VSGNGDIGQQ SIQLENSGTK
VEEDSWLNGT VFIDKTVGND TFFVITWEKQ APNIFVYDPS GKIYNSNDFK IDSTTHTARL
NIPGTAQTGH WNYGIRNSGI GQVITISVTS RAADEKAPPV TVHVYISEKD LDGHRTIYAQ
VSQGFSPVLF ANVTVIIERP TGPTIEQQLC DNGLNADIVK NDGIYTKYFS KYSGYGRYNF
KVRVQGEEGK TKTAIRTGGY SFYIPGYTEN GIIQTNPPKP SINVADLEAD IGDFNRVKSG
GAISVAEGTL NVDIPPCKIT DLQAALAQNK VVLEWTAPGE DYDEGAGNCC
//
