ID A0A401RQD8_CHIPU Unreviewed; 708 AA.
AC A0A401RQD8;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=Hepatocyte growth factor-regulated tyrosine kinase substrate {ECO:0000256|ARBA:ARBA00015450};
GN ORFNames=chiPu_0018957 {ECO:0000313|EMBL:GCC20398.1};
OS Chiloscyllium punctatum (Brownbanded bambooshark) (Hemiscyllium punctatum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Galeomorphii; Galeoidea; Orectolobiformes; Hemiscylliidae;
OC Chiloscyllium.
OX NCBI_TaxID=137246 {ECO:0000313|EMBL:GCC20398.1, ECO:0000313|Proteomes:UP000287033};
RN [1] {ECO:0000313|EMBL:GCC20398.1, ECO:0000313|Proteomes:UP000287033}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=30297745; DOI=.1038/s41559-018-0673-5;
RA Hara Y, Yamaguchi K, Onimaru K, Kadota M, Koyanagi M, Keeley SD, Tatsumi K,
RA Tanaka K, Motone F, Kageyama Y, Nozu R, Adachi N, Nishimura O, Nakagawa R,
RA Tanegashima C, Kiyatake I, Matsumoto R, Murakumo K, Nishida K, Terakita A,
RA Kuratani S, Sato K, Hyodo S Kuraku.S.;
RT "Shark genomes provide insights into elasmobranch evolution and the origin
RT of vertebrates.";
RL Nat. Ecol. Evol. 2:1761-1771(2018).
CC -!- SUBCELLULAR LOCATION: Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004469}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004469}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004469}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GCC20398.1}.
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DR EMBL; BEZZ01001757; GCC20398.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A401RQD8; -.
DR STRING; 137246.A0A401RQD8; -.
DR OMA; DQQCSAK; -.
DR Proteomes; UP000287033; Unassembled WGS sequence.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR CDD; cd15720; FYVE_Hrs; 1.
DR CDD; cd21387; GAT_Hrs; 1.
DR CDD; cd03569; VHS_Hrs; 1.
DR Gene3D; 1.20.5.1940; -; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR017073; HGS/VPS27.
DR InterPro; IPR024641; HRS_helical.
DR InterPro; IPR003903; UIM_dom.
DR InterPro; IPR002014; VHS_dom.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46275; HEPATOCYTE GROWTH FACTOR-REGULATED TYROSINE KINASE SUBSTRATE; 1.
DR PANTHER; PTHR46275:SF1; HEPATOCYTE GROWTH FACTOR-REGULATED TYROSINE KINASE SUBSTRATE; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF12210; Hrs_helical; 1.
DR Pfam; PF00790; VHS; 1.
DR PIRSF; PIRSF036956; Hrs_Vps27; 2.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00288; VHS; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS50330; UIM; 1.
DR PROSITE; PS50179; VHS; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000287033};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 8..136
FT /note="VHS"
FT /evidence="ECO:0000259|PROSITE:PS50179"
FT DOMAIN 153..213
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 219..319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 570..626
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 647..708
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 445..487
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 280..312
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 647..667
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 683..708
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 708 AA; 79281 MW; AB93DA7CB1574F55 CRC64;
MREVYDKATS QLLLETDWES ILQICDLIRQ GDAQAKYAIG AIKKKLNDKN PHVVLYTLEV
LESVVKNCGQ TVHDEVANKQ TMEELKELFK KQVETNVRTK ILQLIQAWAQ AFRNEPKYKV
VQDTYQIMKV EGNVFPEFKE SDAMFLSERA PDWVDAEECH RCRVQFGVVT RKHHCRACGQ
IFCGKCSSKS STIPKFGIEK EVRVCEPCFE QLNKKSEVKS TTSAPVDLPP EYLTSPLSQQ
SQLPPKRDEA ALQEEEELQL AIALSQSEAE EKERMRQKNT YSMYPKTDPT PVTSSAPPVS
SLYSSPVNSS APTAEEIDPE LARYLNRNYW EKKQEEVRKS PTPSAPVSVV ESVTQPIETQ
TTPVAVVEQQ YQNGESEENH DQFLKALQNS VVTFVNRMKS NHMRGRSITN DTAVLSLFQS
INNMHPQLLE LLNQLDEKRL YYEGLQDKLA QIRDARGALN ALREEHCEKL RRAAEEAERQ
RQIQLAQKLE IMRQKKQLQS MPPASGVMYQ PAGPTSFPGT FSPAGSVEGS PMHSVYMNQT
GQPGTGPYTS MPVSGADPNM VNPYMYQAAA PTSQTTQQSQ GVSTTNTGYS NYQPTPTQSY
QNVVSQAQGG TLSQPPQSGG LGYMGSQSVP MGYQTYNMQN MMSTLPAQDP AMSNLPPQQS
YLPAQQPMYQ QMAPPGGAPP QQQPQQPQQQ IQQQQQQAGS EAQLISFD
//
