ID A0A401S153_CHIPU Unreviewed; 3759 AA.
AC A0A401S153;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=AAA+ ATPase domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=chiPu_0002508 {ECO:0000313|EMBL:GCC24108.1};
OS Chiloscyllium punctatum (Brownbanded bambooshark) (Hemiscyllium punctatum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Galeomorphii; Galeoidea; Orectolobiformes; Hemiscylliidae;
OC Chiloscyllium.
OX NCBI_TaxID=137246 {ECO:0000313|EMBL:GCC24108.1, ECO:0000313|Proteomes:UP000287033};
RN [1] {ECO:0000313|EMBL:GCC24108.1, ECO:0000313|Proteomes:UP000287033}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=30297745; DOI=.1038/s41559-018-0673-5;
RA Hara Y, Yamaguchi K, Onimaru K, Kadota M, Koyanagi M, Keeley SD, Tatsumi K,
RA Tanaka K, Motone F, Kageyama Y, Nozu R, Adachi N, Nishimura O, Nakagawa R,
RA Tanegashima C, Kiyatake I, Matsumoto R, Murakumo K, Nishida K, Terakita A,
RA Kuratani S, Sato K, Hyodo S Kuraku.S.;
RT "Shark genomes provide insights into elasmobranch evolution and the origin
RT of vertebrates.";
RL Nat. Ecol. Evol. 2:1761-1771(2018).
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GCC24108.1}.
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DR EMBL; BEZZ01000047; GCC24108.1; -; Genomic_DNA.
DR STRING; 137246.A0A401S153; -.
DR OMA; QRENMAG; -.
DR Proteomes; UP000287033; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703:SF4; DYNEIN AXONEMAL HEAVY CHAIN 17; 1.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 3.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000287033}.
FT DOMAIN 197..684
FT /note="Dynein heavy chain tail"
FT /evidence="ECO:0000259|Pfam:PF08385"
FT DOMAIN 1156..1277
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 1276..1334
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 1334..1408
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 1561..1728
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 1887..2004
FT /note="Dynein heavy chain AAA 5 extension"
FT /evidence="ECO:0000259|Pfam:PF17852"
FT DOMAIN 2230..2357
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 2457..2800
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 2827..3044
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 3244..3309
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 3320..3456
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 3465..3757
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT COILED 2442..2535
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2679..2727
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3034..3064
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 3759 AA; 430635 MW; D13960D4AC2B2338 CRC64;
MEQDEETHEQ EADPRMAFLQ SLSLMFFSMK PDKWTKFSGT EENKNLLMDF FNTEDVMILV
LYINSVGQLT ASLGFPASIK TKGIYFVKKK MVRITPENIR DSLSVGDISN SPVEQLLTVL
EEVVCTLFTN TDNMTTWPQV VSEDVVKHAQ QLKNDVFVFG GQLKGKALLA LPKSADDLED
SDEESDSSTI QVDGATLHAI ESVVIDWTHQ VKDVLNKDSA QALLDGLNPL PREEIDFWDL
RLKDLKCLHE QLWMPKARKI SEVLEKSKSS YWPALKSLYD DIRAGLEEAS DIVLHLIPLK
SLIEDLEQTE YSEVSPYVDI ILHTVCLVWA NSRYYNTPAR IIVILQEIFN LFIHMTCNFL
NPEELMKGLQ GEIEEVLETI HMTISVLKKL YQVYDHKRSE MHTFFKDREP KYWEFPSHLA
FARLDRFMHR LQTIEEIFST TVEFLKLEKI EVGGVRGNLL GQMVQQIYLE FLEDIKIFAD
CTYNALDIAE HKFEEDHAVF QRKIDDFDRR LAMIICQGFS DCASILPAVK MLNMFAFFIK
RPLIKEEVSQ KYPILVDMIN NDLDNIKSIF DAHLTAMAEK NVPTINRNMP YVAGELKWAQ
EVNERMEVSM KCFNSIDYSY TSNDEAKHIL NKHTEMKSLL EKFSEQVYTD WIMKVDEDCQ
FNLKQPLITR NPTTNLISVS FSKKEWSTSP LFERGGNKKD SFLDLDGRQN MLNKRYAAVT
EDGVKLHALL EENRILFHAD VKDPSWEKYV NYIDEMVVEG FHAVVQKSLQ FLLSNMESQA
HASPLFEVRL ELTESDTEFR PTIGIGSEFY NLIETLMNDV YKFVGLVPRL AKHVTRKKYQ
IDLEEMTDLT EMREEIMTLV ITTMRQAEKY EESFDSYSYL WVDDRNEFLE EFLIYGRVLT
QEEIESYGEG GVPPTPPTLE QFKNQIDSYE QLYEEVLKFE TVKILDSWFK IDCRPFRQAL
LNLIKRWSLL FKQYLINHVT DSLSTLEAFI KETNAELSKT VKEGDLKALI QVMGYLKKVK
ERQVTTDNMF EPLKQTIELL KTYDVEMPEE VHTQLHDLPE QWNNTKKISV ICKHAVAPLQ
ANEVNVIRRK CLRFEINQHG FRQKFKVKAP FKFDNPNPYK ALDKAQKKIV AMEVELQALA
QSAALFEVSV PDCKQLKACR KEIVLLKDLW DMVILVSLTI EDWKTTKWKN ISVENMDADC
KKFVKDLRSM DKEIRAWDVY SGLDNLIKNT MTSLKAVNFV MSDETTLADL LSLQLHNFED
EVRNIVDKSV KESGMEKVSS WQQKLSTADA VISIWFEVQR TWVHLESIFI GSEDIRMQLP
EDSKRFEVID VDFKVSQHLS KLFDNMAKLK FQLDADNNPM KVGIGMYSKE QEYVPFDKPC
DCSGQVEIWL NRLLDRMCAT LRHEIAEAVV AYEEKPREQW IFEYPAQIAL TGTQIIWNGE
VSSTFAKLEE GYENAMKDYL KKQISQLNSL ITLLIGNLSV GDRQKIMTIC TVEVHARDVV
NKMITTKVEN IQAFTWQSQL RHRWDDEKQH CFANICDAQF RYSYEYLGNT PRLVITPLTD
RPCAMVVPDF ELICEIMLVA EGFIDARLLA RKFITLYTLC KELLSKQDHY DWGLRAIKSV
LVVAGSLKRG DPTRPEDQVL MRALRDFNIP KIVTDDLPVF MGLIGDLFPA LDVPRKRDLD
FEQVVRQSIL ELHLQPEDSF VLKVIQLEEI LQVRHSVFVV GNAGTGKSQV MLSLKTTYLK
MKRKAITIDL DPKAVTCDEL FGVINPATRE WKDGLFSTIM RDLANISHDG PKWIVLDGDI
DPMWIESLNT VMDDNKVLTL ASNERIPLNP TMRLLFEISH LRTATPATVS RAGILYINPA
DLGWNPVVAS WIESREVQSE KANLLILFDK YLPTCLEKLR TGFKMITPIP EITMVQTVLH
LMECLLTPIN TPADSPKELY ELYFVFTCVW GFGGTMFQDQ LVDYRVEFSK WWVNEFKSVK
FPSQGTIFDY YIDSESKRFM PWTDKVPTFE LDSDLPLQAA FVHTTETIRL RYFIDLMLEI
GRPIMLAGNA GTGKSVLMWE KLNSLNIEDY LIQAVPFNFY TNSAMLQAVL EKPLEKKTGR
NFGPPGIKKL IYFIDDMNMP EVDKYGTVAP HTLIRQHLDH GHWYDKVKLT LKDIHNCQYV
ACMNPTAGSF TIDSRLQDMD ESALFQKPNI FCHFASGIGE PKYLPVKNWN SLNKILVEAL
DGYNEINAVM NLVLFEDAMA HICRINRILE SPRGNALLVG VGGSGKQSLS RLAAYISSLN
VFQIALKKGY SVADLKVDVG AQYINAGVKN HGTVFLMTDS QVAEEIFLVL INDLLASGEI
PGLFQDDELE NIIVRARKFP ALVNCTSIDW FHEWPEEALV SVSQRFLEET EGIESDVKHS
ISLFMSFVHK SVQEMSSIYL STERRYNYTT PKTFLEQIKL YQNLLSKQRK ELIAKMDRLE
NGLAKLNSTA GQVDDLKSKL AIQEVELQQK NEDADKLIKV VGQQTEIVTK NKKIADEEEK
KVQIINENVR EKQQSCEEDL AKAEPALIAA QEALNTLNKN NLTELKSFGS PPDAVVLVAA
AVMILLAPSG KLPKDKSWKA AKVMMGKVDS FLDSLINYDK EHIPDSSLKA FRPILENAMF
DPDFIRTKSI AAAGLCSWCI NIVKFYEVFC EVEPKRIALA QANAELAAAQ EKLAGITRMI
NELDDNLAKL TAEFEKATSE KLKCQQEADN TNRTISLANR LVGGLVSEKI RWGDSIAKFK
EQEKTLCGDV LLVTAFVSYL GYFTKKYRNE LLNDHWMPFL QQLEVPIPIT ENLDPLSLLT
DDVDIAAWNN QGLPSDRTSS ENATILCNTE RWPLIIDAQL QGIKWIKRKY GDDLKVIRLG
QRGYLDKIEH AVANGDTLLL ENISETVEPV LDALLGRNTI KKGKYIHIGD KEVEYHPNFR
MILQTKYFNP HFKPEMQAQC TLINFLVTRD GLEDQLLAAV VAKERPDLEE LKARLTTQQN
EFKIVLKQLE DSLLARLSEA SGNFLGDTAL VENLETTKQT ATEIEQKVAE AKVTEVKINE
ARENYRPAAQ RASLLYFVID DLNKINPIYQ FSLKAFHVTF EKAIQRSVPA DDVKERVLNL
TDEITYSVFV YITRGLFERD KLIFTAQVAF QVLAEMEQFK NLDSDIEGSA NRWKKIVESE
APEKEKLPQE WKNKGPMEKL CMMRCMRPDR MTYAVSGFVE EKLGAKYVEG RSMEFAKSYE
ESSPSIPIFF ILSPGVDPLK DVEALGKKLG FTIDNGKFHN VSLGQGQEIV AEQALDEAAA
DGHWVILQDT LEMCSKESEF KCILFALCYF HAVVAERRKF GAQGWNRAYP FNNGDLTISV
YVLYNYLEAN PKVPWDDLRY LFGEIMYGGH ITDDWDRKLC RTYLEEYIKN EMLDGELLLA
PGFPIPPNSD YKGYHDYVNE MLPPESPYLY GLHPNAEIGF LTVISEKLFR TVLELQPKES
AAESGGGVTR EEKVKSVLDE ILEKLPESFN MHEIMGKVEE RTPYVVVAFQ ECERTNILTA
EIKRSLKELN LGLKGELTIT ADMEEISNAL FFDTVPATWA ALAYPSLFSL GAWFSDLLLR
IRELEAWSTD FALPSAVWLG GFFNPQSFLT AIMQSMARKN EWPLDKMCLA VEVTKKNRED
MTSAPREGAY IHGLFMEGAR WEKNSGIITD ARLKELTPGM PVVFIKAIPV DRQETKNIYE
CPVYKTRSRG PTYVWTFNLK TKESRAKWIL AGVAVLLQV
//
