ID A0A401S2H0_CHIPU Unreviewed; 4312 AA.
AC A0A401S2H0;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Cytoplasmic dynein 2 heavy chain 1 {ECO:0000256|ARBA:ARBA00023902};
GN ORFNames=chiPu_0002986 {ECO:0000313|EMBL:GCC24584.1};
OS Chiloscyllium punctatum (Brownbanded bambooshark) (Hemiscyllium punctatum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Galeomorphii; Galeoidea; Orectolobiformes; Hemiscylliidae;
OC Chiloscyllium.
OX NCBI_TaxID=137246 {ECO:0000313|EMBL:GCC24584.1, ECO:0000313|Proteomes:UP000287033};
RN [1] {ECO:0000313|EMBL:GCC24584.1, ECO:0000313|Proteomes:UP000287033}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=30297745; DOI=.1038/s41559-018-0673-5;
RA Hara Y, Yamaguchi K, Onimaru K, Kadota M, Koyanagi M, Keeley SD, Tatsumi K,
RA Tanaka K, Motone F, Kageyama Y, Nozu R, Adachi N, Nishimura O, Nakagawa R,
RA Tanegashima C, Kiyatake I, Matsumoto R, Murakumo K, Nishida K, Terakita A,
RA Kuratani S, Sato K, Hyodo S Kuraku.S.;
RT "Shark genomes provide insights into elasmobranch evolution and the origin
RT of vertebrates.";
RL Nat. Ecol. Evol. 2:1761-1771(2018).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GCC24584.1}.
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DR EMBL; BEZZ01000061; GCC24584.1; -; Genomic_DNA.
DR STRING; 137246.A0A401S2H0; -.
DR OMA; WCKERVS; -.
DR Proteomes; UP000287033; Unassembled WGS sequence.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR GO; GO:0006996; P:organelle organization; IEA:UniProt.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR049400; DYNC2H1_AAA_dom.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703:SF22; CYTOPLASMIC DYNEIN 2 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF21264; DYNC2H1_AAA_dom; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Cilium biogenesis/degradation {ECO:0000256|ARBA:ARBA00022794};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000287033}.
FT DOMAIN 195..651
FT /note="Dynein heavy chain tail"
FT /evidence="ECO:0000259|Pfam:PF08385"
FT DOMAIN 1121..1521
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 1654..1987
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 2122..2217
FT /note="Cytoplasmic dynein 2 heavy chain 1 AAA+ ATPase"
FT /evidence="ECO:0000259|Pfam:PF21264"
FT DOMAIN 2626..2878
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 2894..3224
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 3250..3474
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 3724..3833
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 3866..4006
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 4016..4309
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT COILED 2894..2967
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3110..3193
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4312 AA; 492784 MW; CE2745FFD7176077 CRC64;
MPASLEDPRK SFILRTAGNY FGFPPSDSLI SSLENRRELN NFLDDGNVFV ISLQKSADQL
LICNKVVPGD KKDKILVFFK MRPDVITEDN LHTNILVSSM LDSPIIALYQ AIRQIFAPVL
LKDEKWSKNF DPKLQNLLTQ LEAGLGSVVR HSDHSCSGSK FGGEQDTSGI LEPSDEFQFW
AEVAASDDKP DRKERAQHFE ELFQTISQYN NLDALSLADV VDLVETTRDT VDDVWRQTEH
DFYPELRMHH LLDVIGNALG RFVQKTLMQL NLWGDPFHTV KESLRSGITI CEQWVAASDH
LTGQLWRRYT PHQWKSEKYY PGSLAKLAKR LEEIQTSRTI HEKLLRLLPA GEQQLLHNAQ
VFESFAGLNP VQYNPYTEPL WKAAVAQFER SIAPSEQKVA SKLKVFIVEV QDNPQQLLQA
FQKYKELVKR PSISKELLSE REMLLAKLTE YIKGICTDFE SRRRGIPGEP SGPLSGKNLP
EVVNNIVWVR QLQLKAEDTV KIAEALLSDL SGFQSFWRNC NEFLDQLKTY EQDQFDDWSR
DIQSSVLDPS AGISLQASGR VIELDHSDGK LKIHYSDRLV SLLREVRQLS ALGFTIPARI
QQTAVTAQKF YRQAIILKQV AHFYNTIDQQ MIPSQRPMML SSALSFEQLI KNPKAGSKES
GSKLQITWDN PKELEAYIQK LNTAAERLTT ENRKLRKCHT DFRDKVVALM SIDLLRQQQR
WKDGLQELRF VFSTLESQGF HSGDMKAWRQ HWNHQLYKAL EHQYQMGLEA LNENLPEIVV
ELTFKQGRLQ FKPPFEELRA KYYREMKRFI CIPNQFKGTC EPGEDPIFVV MIERNAKGFV
TVFRKAEDLF KRLAAALEKF QEWIVLGQVD VEALIEEHLH TVNDWEKNFK ALKGRGKESE
KLPSVIKVDC ITINCNPVKA MIDDHIQMLF DALLQSLRKS IQVNIHEIDS FVSGAMEILS
TRPETVEEIG EANSKHTEIA SKKPHVLPLF QDAEDKNKLL RSVAGGGLET LSSLRAKWDK
FQLMMESHQL MVKEQVEIMK SNVESRIKMY IQKLEKFEAR WNQLKPSDDI VDSGNGETLN
KCVECIKEKR VEFDELETTR KKLIEDCQHF KVEEPEFELA ERLRKNLEQY ESMWSLYEDF
TKGLQNMLNE DWISFRGKIY IFEDFLLMWH DKLRKRNEQT TITVKLQKDV DRYKMLFPVL
KYVRGEHLSQ DHWLDLFRLL GMPRGTTIEK LQFGDLLKVA DVIVAKSSDL KELNSRAQGE
VSIREALREL DMWGAASVFM MTDYQDSHKV TIKLIKDWKD IVNQVGDNQC LLQTLKDSPY
YKGFEDKVSL WEIRLADLDE YLHNLNQIQR KWVYLEPIFG RGALPKEQGR FKRVDDDFRS
IMADVERDNR VTSLCMRAGI RHSLITILDQ LQRCQKSLNE FLEEKRSAFP RFYFIGDDDL
LEILGQSTNP SIIQSHLRKL FAGINSVDFD DDFKHIIAMK SLDGEVVPLK SKIRVIDDVE
VWLNNLAEVM KETLKHLLVE CIAAWKQSQG AIDPLRFPSQ ILCLAEQIQF TEEVENAIKN
HSLQQLDVEL MAKLENYTSI DSYSEETGNA ETTVLELKLK ALILDIIHNI EVVKQLNQAQ
VCNTSDWAWK KQLRFYMKPD NNCYIQMVDA EFQYTYEYQG NAPKLVHTSL TDKCYLTLTQ
AMKMGLGGNP YGPAGTGKTE SVKALGGLIG RQVLVFNCDE GIDVKSMGRI FIGLVKCGAW
GCFDEFNRLE EAVLSAVSMQ IQAIQDALKD HRRFCELLGK QVDLDPNSGI FITMNPAGKG
YGGRQKLPDN LKQLFRPVAM SRPDNELIAE VILYAEGFKD GNILGRKLVA LFTLSKELLT
PQQHYDWGLR ALKTVLKGCG NLLQQRKKSK TKIDESHIVV QALRLNTMSK LTFADCTRFD
ALVRDIFPGV NFKDFEYVDL AAALNEAFEE ANLEIIPNQI KKALELFEQL RQRMGVVIVG
PSGAGKSILW RMLRTALGKI NKVVRQYTMN PKAMPRQHLL GHIDIDTREW SDGVLTNSAR
QVVREPQDIH SWIICDGDID PEWIESLNSV LDDNRLLTMP SGERIQFGPN VNFVFETHDL
SCASPATISR MGMIFLSDED TDVSSLVKSW LRNQVDECRS NLESWIGDYF EKCLNWVLKQ
NDFVVETSLV GTVLNGLSHL HGCTDRGQFI ISLIRGLGGN LNMKSRQEFS KEVLNWARES
PPDPRQPLDT YYDQLSGRLM AYQMEKPENL TADDFCNPQK LPVIRTPDMQ RGLDYFKPWL
SSSNKQPFIL VGPEGCGKGM LLRYAFSQLR STQIATIHCS AQTSPQHILQ KLSQTCMVIS
SNTGRVYRPR DCEHLVLYLK DINLPRPDKW STSSVIAFLQ QALTYHGFYD ENLEWVGLEN
IQIVASMSVG GVMGRHTLTT RFTSIVRICT INYPDREQLQ AIYSAYLQPV LHRNLKHHPT
WSCPTRIHQL AGSLVQVYEQ VRTKFTVDDN SHYLFTPCIL TQWVLGLFRY DLEEGESQQS
VDHVLEVVAY EAHRLFRDRI VGSKNLIAFD NILISVIRGD WGSDLLDNMT DFFYVTWGAR
HEAGSVTAPD QPLPPYGKML GKLRSSDLRE VIQKGIVHYG RDNRELNILL FHEVLDFMAR
IDRVLSCPGG SLLLAGQSGV GRRTATCIVS HMHGATLFTP KISRNYEIKQ FKNDLKHVMQ
LAGLDGHQVV LLLEDYQFVH ARFLEMVNSL LSSGEVPGLY TPEELEPILS PLKDQASQDG
FTGPIFNYFA YRIQQNLHVV LIMDCTNSNF TINCESNPAF YKKCSVQWME GWSNSSMKKI
PEMLLSLNCV SEKKEKGRRS SISGDADLTK SFLMIHESCK IYGATPHRYM IFLNVYNSIY
NIKKSDLIKR QSHLQAGVSK LNEAKDLVDE LKRKAAEQSI LLKTKQAEAD AALQEITVSM
QNASEQKTEM EQIKQKIAEE VVKIEKRKSV IDNELKQVQP HVDEAKRAVG NIKPESLSEI
RSLRMPPDVI RDILEGVLRL MGIFDTSWVS MKSFLAKRGV REEIATFDAW NISREIRESV
EGLLQKNSAS FDPKNAKRAS AAAAPLAAWV RANVKYSYVL EKIQPLEKEQ AALVENLSKT
EERKQNLEVK LCSVGRKVAE LKEKFQIRTT EAAKLEAEVN KAQETIEAAE KLIRQLDGEH
RRWNAQVAEI TEELNTLPKR AQLAAGFITY LSAAPEDQRK ASLEEWMKSS GLQKFDLRHF
LYTESEQLIW KSEGLPSDDL SVENALVILQ INKLKIRSRI CPFLIDPSSR ATEWLKSHLK
EARLEVINQQ DSNFITAVEL AVRFGKTLII QEMDGVEPVL YPLLRRDLIA QGPRYVVQIG
DKIIDYNEEF RLFLATRNPN PSIPPDAASI VNEVNFTITR EGLREQLLAV TLQHEKPELE
ERKTTLLQQE EEKKIQLAKL EDSLLEKLAT SQGNILENKG LIESLNQTKA SSALIQESLN
ESFKLQVSLD QERDAFLPLA ETASKMFFII TDLSKINNMY RFSLSAFLRL FQRSLQSRKD
SENTDVRITS LIGSLKTSVY EYICRSLFKA DQLMFALHFV RGMYPELFQE NEWDAFTGLI
VGDMLRKSDN QKSIRESIPS WIDQERVGGV ALLKATFPAL YQTLCLEDIE LWLTFSQSST
CEQDIPTSIA RRISLFQQVL VVQAIRPDRL QSAMALFASK ALGMKELSPP PLNLKRLLTE
MLAAEPVLII ISPGADPSQE LQELASETIG RENFHEVAMG QGQADIAIQT LKECARNGEW
LCLKNLHLVT VWLPVLEKEL NRLEPHTNFR LWLTSESHPK FSPILLQSSL KITYEAPPGL
KKNLMRTYES WTSEQIARKG ILERAQSLFS LAWFHAVCQE RRKYIPQGWT KFYEFSLSDL
RAGFEIIDRL FEERKDVQWE FVRGLLENAI YGGRIDNIFD LRVLNSYLEQ FFSPRAIAGS
QSRSKNIASF PSSITVPRSC SIMDYRAIIT HLPEDDKPAY FGLPANIERS SQCIFSNQVI
SQLRILSRSM TAGSKFDRDI WSNELSPILN LWKKLNQGSQ LIHQKLSPLN EKQGSPIQSF
IALEQYNAIR LVQSIHQSLA AMSKVIRGTS LLTPSVQKLA TALMNQECPI SWQNKWEGPE
DPMQYLRGLV ARALAIQVWV EKAANQTLLS DTLDLSELFH PDTFLNALRQ ETARVMSCSI
DNLKFVATWK GRMQDVKLQV RIGGLYLEGC SFDGNRLSEN QHDSPSVSAV PTCYMAWIPQ
NVDGPYSPEE CISLPVYTSA ERDQVVINID VPCGVNQDQW IQSGAALFLK NQ
//
