ID A0A401S3D3_CHIPU Unreviewed; 1434 AA.
AC A0A401S3D3;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 13-SEP-2023, entry version 12.
DE RecName: Full=SSD domain-containing protein {ECO:0000259|PROSITE:PS50156};
GN ORFNames=chiPu_0003320 {ECO:0000313|EMBL:GCC24917.1};
OS Chiloscyllium punctatum (Brownbanded bambooshark) (Hemiscyllium punctatum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Galeomorphii; Galeoidea; Orectolobiformes; Hemiscylliidae;
OC Chiloscyllium.
OX NCBI_TaxID=137246 {ECO:0000313|EMBL:GCC24917.1, ECO:0000313|Proteomes:UP000287033};
RN [1] {ECO:0000313|EMBL:GCC24917.1, ECO:0000313|Proteomes:UP000287033}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=30297745; DOI=.1038/s41559-018-0673-5;
RA Hara Y, Yamaguchi K, Onimaru K, Kadota M, Koyanagi M, Keeley SD, Tatsumi K,
RA Tanaka K, Motone F, Kageyama Y, Nozu R, Adachi N, Nishimura O, Nakagawa R,
RA Tanegashima C, Kiyatake I, Matsumoto R, Murakumo K, Nishida K, Terakita A,
RA Kuratani S, Sato K, Hyodo S Kuraku.S.;
RT "Shark genomes provide insights into elasmobranch evolution and the origin
RT of vertebrates.";
RL Nat. Ecol. Evol. 2:1761-1771(2018).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GCC24917.1}.
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DR EMBL; BEZZ01000070; GCC24917.1; -; Genomic_DNA.
DR STRING; 137246.A0A401S3D3; -.
DR OMA; HLYDTEW; -.
DR Proteomes; UP000287033; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008158; F:hedgehog receptor activity; IEA:InterPro.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR InterPro; IPR004766; TM_rcpt_patched.
DR NCBIfam; TIGR00918; 2A060602; 1.
DR PANTHER; PTHR46022; PROTEIN PATCHED; 1.
DR PANTHER; PTHR46022:SF5; PROTEIN PATCHED HOMOLOG 1; 1.
DR Pfam; PF02460; Patched; 1.
DR Pfam; PF12349; Sterol-sensing; 1.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000287033};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 428..447
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 459..484
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 490..512
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 533..556
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 562..585
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1018..1039
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1045..1067
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1074..1100
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1112..1132
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1144..1166
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 427..587
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 674..700
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1202..1223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1266..1346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1204..1223
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1266..1282
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1283..1327
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1434 AA; 160347 MW; 2B1276BE4D43EA4F CRC64;
MASAVNTAER RRTEQDHVQE NRRKRRRNLR HPTAVLDYLE RPSYCDAAFA LDQISKGKAT
GRKAPLWLRA KFQKLFFKLG CYIQKNCGKF FVVGLLIFGA FAVGLRAANL ETDVEELWVE
VGGRVSQELS YTRQKIGEEA MFNPQIMIQT SPEEGASVLT VEALQQHLNS AFNASRVQVY
LYNKQWTLDN LCYKSGALVT ETGWMDQLIE KLYPCVIITP LDCFWEGAKL QLGTVYLPGK
LQLQWTNLDP LEFLEELKNL KYEVGGWEEM LNKAGVGHGY MDRPCLNPAD PDCPLTAPNK
NSTTPLDIAR VLSGGCHGLS KKYMHWQEEL ILGGTTKNST GILQSAQAFQ TMFQLMTPKQ
MYEHFKDYYY VSDINWNPDK AAAILEAWQR KYVEVVHQSV AQNSTQKVLS FSTTTLEDIL
KSFSSVSVIR VAGGYLLMLA YACLTMLRWD SAKSQGAVGL AGVLLVALSV AAGLGLCSLI
GISFNAATTQ VLPFLALGVG VDDIFLLAHA FSETGHNKKI PFEDRTGECL KRTGASVALT
SISNVTAFFM AALIPIPALR AFSLQAAVVV VFNFAMVLLI FPAILSMDLY RREVRRLDIL
CCFTSPCANR VIQIESQAYR DTNDNHPCQP PPPYINQNFT HETQITMQST VQLRTEYNPH
TQAYYTTAEP RSEISVQPVT TTTQDSLSSQ SPETASSTRD LLSQFTDPNS NCVDPPCTKW
TLSSFAEKHY APLLLKRTTK IVVTLLFLGL LGISLYGTTT VRDGLDLTDI VPRETREYDF
IAAQFKYFSF YNMYIVTKQE TDYPSAQHLL YYLHKSFRNV KFILLEDNGE LPNMWLHYFH
NWLKGLQDTF DREWQAGKIT HNSYKNGSDG GVLAYKLLIQ TGNRHRPTDL SQLTKQRLVS
ADGIINPNAF YIYLTAWVSN DPVAYAASQA NIRPHPPEWV HDKTDDRPET ALRIPAAEPI
EYAQFPFYLN GLRETSDFVE AIEKVRNICS NFTNQGLASY PNGYPFLFWE QYVGLRHWLL
LAISVVLACT FLVCALFLLN PWTAGIIVLV LALMTVELFG MMGLIGIKLS AVPVVILIAS
VGIGVEFTVH VALAFLTAIG DKNRRAVLAL EHMFAPVVDG AVSTLLGVLM LAGSEFDFIV
RYFFAVLAIL TVLGVLNGLV LLPVLLSCFG PYPEVSPLDG RTRLPTPPLE PPVRVVRFAI
HPEQGNNGSD TSDSEYSSQT TVSGISEELH HYESNPSSTA PAHQIMVEAT ENPVFPRSTV
IQPDCRLHQP RSQPPSRQDV KHQQSWRNCR DHSLEAREGF RPPPYKPRMD AFETAHEGHS
RLGNRDHPTH RSRSHKTRNP TFTATGAAAP PYCQPITTVT ATASVTVAVH PPIPNQNVFG
GHPHCEGYSG TDEGAFVDPH VPFNARYERR NSKLEVLELQ DVECETQRNG NKTH
//
