ID A0A401S460_CHIPU Unreviewed; 1046 AA.
AC A0A401S460;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Protein tweety homolog {ECO:0008006|Google:ProtNLM};
GN ORFNames=chiPu_0003607 {ECO:0000313|EMBL:GCC25200.1};
OS Chiloscyllium punctatum (Brownbanded bambooshark) (Hemiscyllium punctatum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Galeomorphii; Galeoidea; Orectolobiformes; Hemiscylliidae;
OC Chiloscyllium.
OX NCBI_TaxID=137246 {ECO:0000313|EMBL:GCC25200.1, ECO:0000313|Proteomes:UP000287033};
RN [1] {ECO:0000313|EMBL:GCC25200.1, ECO:0000313|Proteomes:UP000287033}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=30297745; DOI=.1038/s41559-018-0673-5;
RA Hara Y, Yamaguchi K, Onimaru K, Kadota M, Koyanagi M, Keeley SD, Tatsumi K,
RA Tanaka K, Motone F, Kageyama Y, Nozu R, Adachi N, Nishimura O, Nakagawa R,
RA Tanegashima C, Kiyatake I, Matsumoto R, Murakumo K, Nishida K, Terakita A,
RA Kuratani S, Sato K, Hyodo S Kuraku.S.;
RT "Shark genomes provide insights into elasmobranch evolution and the origin
RT of vertebrates.";
RL Nat. Ecol. Evol. 2:1761-1771(2018).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the dynein intermediate chain family.
CC {ECO:0000256|ARBA:ARBA00011059}.
CC -!- SIMILARITY: Belongs to the tweety family.
CC {ECO:0000256|ARBA:ARBA00009849}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GCC25200.1}.
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DR EMBL; BEZZ01000080; GCC25200.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A401S460; -.
DR STRING; 137246.A0A401S460; -.
DR Proteomes; UP000287033; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR006990; Tweety.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR12442:SF7; DYNEIN AXONEMAL INTERMEDIATE CHAIN 2; 1.
DR PANTHER; PTHR12442; DYNEIN INTERMEDIATE CHAIN; 1.
DR Pfam; PF04906; Tweety; 2.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Reference proteome {ECO:0000313|Proteomes:UP000287033};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT TRANSMEM 43..67
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 87..108
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 148..168
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 175..195
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 335..355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1023..1046
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1046 AA; 118449 MW; 724A0FABFF7FE89B CRC64;
MASRVDYIAP WWTYWLHNFP HVNLRLQPVD STFNPQDGNY QQALMFLAAI AAVGLALNLI
FISIYLLCIC CCKQTNDEEI KRPHSCCVMW TAVTAGLICC AAVGVGFYGN SETNDGVYQL
TYSIYNANHT LVGVDSLVYM DSHGRVKWMA YLLLLINDLV VCLAAFLGLA KRSRWLLTIM
IISGVLTLIL SWGSLGLDIS AAVGISDFCV APDKFIMNMT RNKVSSDVVH YYLYCSHSIS
NPFQQILSGF QRSLTAMERQ IQGMMYIAVP VFPMAKKDLL GIQLLLNRSE TNLHQLTAML
DCRGLHKARR IAAHNPTRGQ VHSFCSFNSS LGSQTSLHPP ANTNPSQTGT TAPAPEYMNN
TVLFGGNPRY ENVPLIGRSS PPPSYSPSMR ATYLADVPAT GRSAKCARAR YSSPYCSCAP
SLLLGDCQLT GARDSEQDRD RFSYRQRDNK PAAEMMEIVY VYTKIRSEFG RQCNFSDRPA
ELHVDIVPDP SLAENFIEKN PVDVFVQVSK DMSEHEVNTE RFKTESRGIN HVEGGWPKDI
NANDLEHTIR YRKKVEKDEN YVYTLMQLGS LMEHCIKQNN AINIYEEYFD DKEESMERFT
EPLSAKTINV FSDPNEIKRT VSHLSWHPDQ GRKLAISYCC LEFQRAADNM SYESYIWDME
NTSKHEMVIK PVSPLLCLEY NPKDSHILAG GCYNGQMGYW DTRKGSQAVE IPTIEVGHRD
PVYKIIWLQS KTGTECFSAA SDGQVLWWDI RKLSEPVERL ILDVSKKDDP DIAYGAVSLE
FESTMPTKFM VGTEQGVVIL GNRKGKVPAE KIVSTFSGHH GPVYAVQRNP FYPKNFLTVG
DWTARIWSED LRDSCIISTK YHMSNLTDGC WSPVRPSVFF TTKMDGTVDI WDLLFKHSEP
SLSVKVCDEA LYSLRIQDNG RLLACGSHLG TTTLLEFSSG FCTYQKNEKA LANALFERET
KREKILEARQ RELRVKERAK SEQGKVVENK EVDEEETIEY KIAQAENAFF ETIEQERARF
EVETEKMDHQ EKETSEDEGD EVRAAY
//
