ID A0A401S4N0_CHIPU Unreviewed; 4647 AA.
AC A0A401S4N0;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=AAA+ ATPase domain-containing protein {ECO:0000259|SMART:SM00382};
GN ORFNames=chiPu_0003752 {ECO:0000313|EMBL:GCC25342.1};
OS Chiloscyllium punctatum (Brownbanded bambooshark) (Hemiscyllium punctatum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Galeomorphii; Galeoidea; Orectolobiformes; Hemiscylliidae;
OC Chiloscyllium.
OX NCBI_TaxID=137246 {ECO:0000313|EMBL:GCC25342.1, ECO:0000313|Proteomes:UP000287033};
RN [1] {ECO:0000313|EMBL:GCC25342.1, ECO:0000313|Proteomes:UP000287033}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=30297745; DOI=.1038/s41559-018-0673-5;
RA Hara Y, Yamaguchi K, Onimaru K, Kadota M, Koyanagi M, Keeley SD, Tatsumi K,
RA Tanaka K, Motone F, Kageyama Y, Nozu R, Adachi N, Nishimura O, Nakagawa R,
RA Tanegashima C, Kiyatake I, Matsumoto R, Murakumo K, Nishida K, Terakita A,
RA Kuratani S, Sato K, Hyodo S Kuraku.S.;
RT "Shark genomes provide insights into elasmobranch evolution and the origin
RT of vertebrates.";
RL Nat. Ecol. Evol. 2:1761-1771(2018).
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GCC25342.1}.
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DR EMBL; BEZZ01000084; GCC25342.1; -; Genomic_DNA.
DR STRING; 137246.A0A401S4N0; -.
DR OMA; NERQMTR; -.
DR Proteomes; UP000287033; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 2.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 2.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 1.20.920.60; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46532:SF13; DYNEIN CYTOPLASMIC 1 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR46532; MALE FERTILITY FACTOR KL5; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000287033};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1902..2046
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2217..2368
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2588..2738
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2930..3096
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 2391..2411
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3206..3254
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3403..3500
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 2391..2409
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4647 AA; 532906 MW; EEFEFE2BDFAA4769 CRC64;
MSESGGGGGG GGEDGTTGLE VTVQNVADVS LLQKHIRKLV PLLLEDGGEA PAALEAAFEE
KSALEQIKKF LSDPQMHTVL VERTTLKEDV GDEGEEEKEH IAYNINTDIH YGLKSNSLAF
IKRTPVIDAD KPISSQLRVI TLSEDSPYET LHSIISNAVA PFFKSYIRES GKADRDGDKM
APSVEKKIAE LEMGLLHLQQ NIEIPEISLP IHPVITNLAK QCYERGEKPK VTDFGDKVED
PTFLNQLQSG VNRWIREIQK VTKLDRDPAS GTALQEISFW LNLERALYRI QEKRESGEVL
LTLEILKHGK RFHATVSFDT DTGLKQALET VNDYNPLMKD FPLNDLLSAT ELDKIRQALV
AIFTHLRKIR NTKYPIQRAL RLVEAISRDL SSQLLKVLGT RKLMHVAYEE FEKVMVACFE
VFQTWDDEYE KLQVLLRDIV KRKREENLKM VWRINPAHRR LQARLDQMRK FRRQHEQLRA
VIVRVLRPQV TAVAQQSQGE GPEPQDMKVA EVLFDAADAN AIEEVNLAYE NVKEVDGLDV
SKEGTEAWEA ALKRYDERID RVETRITARL RDQLGTAKNA NEMFRIFSRF NALFVRPHIR
GAIREYQTQL IQRVKDDIEA LHDKFKVQYP QSQACKMSHV RDLPPVSGSI IWAKQIDRQL
TAYMKRVEDV LGKGWENHVE GQKLKQDGDS FRMKLNTQEI FDDWARKVQQ RNLGVSGRIF
TIESTRARGR SGNVLKLKVN FLPEIITLSK EVRNLKWLGF RVPLAIVNKA HQANQLYPFA
ISLIESVRTY ERTCEKVEER ISISLLVAGL KREVQGLIAE GIALVWESYK LDPYVQRLAE
SVFSFQEKVD DLLIIEEKID LEVRSLETCV YDQKVFSEIL NRIQKAVDDL NLHSYSNLPI
WVNKLDIEIE RILGVRLQAG LRAWTQVLFG HADDKADVDM DTDAPQTSHK PGGDPKIRNI
VHELHITNQV IYLHPPIEDC RYKLYQELFS WKMIILTLPR IQSQRYQVGF QYELSEEEKF
YRNALTRMPD GPAALEEAHE AVMGIVREVE KYVKVWLQYQ CLWDMQPENI YNRLEDDLNK
WQALLVQIRK ARGTFDNAET RKEFGPVVID YGKVQSKVNL KYDSWHKEVL SKFGQMLGQN
MQEFHSQISK SRQELEQHSV DTASTSDAVT FITYVQSLKR KIKQFEKQVD LYRNGQRLLE
KQRFQFPPSW LYIDNIEGEW GAFNDIMRRK DSAIQQQVAN LQMKIVQEDR AVESRTTDLL
GEWEKTKPVA GNLRPEDALQ ALTIYEGKFG RLKDDREKCA KAKEALELTD TGLLSGSEER
VQVALEELQD LKGVWSELSK VWEQIDQLKE QPWVSVQPRK LRQNLDGLLN QLKNFPARLR
QYASYEFVQR LLKGYMKINM LVIELKSEAL KDRHWKQLMK RLHVNWVVSE LTLGQIWDVD
LQKNEAIVKD VLLVAQGEMA LEEFLKQIRE MWNSYELDLV NYQNKCRLIR GWDDLFNKVK
EHINSVSAMK LSPYYKVFEE DALSWEDKLN RIMALFDVWI DVQRRWVYLE GIFTGSADIK
HLLPVETQRF QSISTEFLAL MKKVTKSPLV MDVLNIPGVQ RSLERLADLL GKIQKALGEY
LERERSSFPR FYFVGDEDLL EIIGNSKNVA KLQKHFKKMF AGVSSIILNE DATVVLGIAS
REGEEVLFKT AVSITEHPKI NEWLTLVEKE MRVTLAKLLA ESVTEVGIFG QGTSIDAADY
ISWIDKYQAQ LVVLSAQISW SENVENALNN GASGSQSPLA PVLVNVEATL TVLADSVLME
QPALRRRKLE HLITELVHQR DVTRMLIKNK VDQPKSFDWL SQMRFYFDPK QTDVLQQLSI
QMANAKFNYG FEYLGVQDKL VQTPLTDRCY LTMTQALEAR LGGSPFGPAG TGKTESVKAL
GHQLGRFVLV FNCDETFDFQ AMGRIFVGLC QVGAWGCFDE FNRLEERMLS AVSQQIQCIQ
EALREHSNPS RDRSSPTITC ELLNKQVKVR ADMAIFITMN PGYAGRSNLP DNLKKLFRSL
AMTKPDRQLI AQVMLYSQGF RTAETLANKI VPFFKLCDEQ LSSQSHYDFG LRALKSVLVS
AGNVKRERIQ KIKKEKGERG EDVDEAEIAE NLPEQEILIQ SVCETMVPKL VAEDIPLLFS
LLSDVFPGVQ YHRGAMTKLR EELKKVCQEM YLTYGDGEDV GGMWVEKVLQ LYQISQINHG
LMMVGPSGSG KSMAWRVLLK ALERLEGVEG VAHIIDPKAI SKDHLYGTLD PNTREWTDGL
FTHVLRKIID NVRGELQKRQ WIIFDGDVDP EWVENLNSVL DDNKLLTLPN GERLSLPSNV
RIMFEVQDLK YATLATVSRC GMVWFSEDVL STDMIFNNFL ARLRNIPLDE GEEEAQRRRK
GKEDEEQEAA SPMLQIQRDA ATVLQPYFTS NGLIIKAVEH AAKMEHIMDF TRLRCLGSLF
SMMHQGCRNI ALYNANHPDF PMPNDQLERY IQKYLIYAIL WSLSGDARLK MRAELGEYIR
RITTIPLPST PNMPIIDFEV SITGEWVPWQ SKVPQIEVET HKVAAPDVVV PTLDTVRHEA
LLYTWLAEHK PLVLCGPPGS GKTMTLFSAL RALPDMEVVG LNFSSATTPE LVLKTFDHYC
EYRRTPNGVV LAPVQLGKWL VLFCDEINLP DMDKYGTQRV ISFIRQMVEH GGFFRTSDQT
WVKLERIQFV GACNPSTDPG RKPLSHRFLR HVPVVYVDYP GPASLTQIYG TFNRAMLRLI
PSLRTYADPL TAAMVEFYMM SQERFTQDIQ PHYIYSPREM TRWVRGIFEA LRPLETLAVE
GLIRIWAHEA LRLFQDRLVE DEERQWTDEN IDVVALKHFP NIDKDKALIR PILYSNWLSK
DYIPVDQEEL RDYVKARLKV FYEEELDVPL VLFNEVLDHV LRIDRIFRQP QGHLLLIGVS
GAGKTTLSRF VAWMNGLSVY QIKVHRKYTG EDFDEDLRTV LRRSGCKNEK IAFIMDESNV
LDSSFLERMN TLLANGEVPG LFEGDEYATL MTQCKEGAQK EGLMLDTHEE LYKWFTGQVI
RNLHVVFTMN PSSEGLKDRA ATSPALFNRC VLNWFGDWST EALYQVGKEF TSKMDLEKPN
YVVPDYMPIA YDKLPQPPSH REAIVNSCVF VHLTLHQANT RLAKRGGRIM AITPRHYLDF
INHYANMFNE KRSELEEQQM HLNVGLRKIK ETVDQVEELR RDLRIKSQEL EVKNAAANDK
LKKMVKDQQE AEKKKVMSQE IQEQLHKQQE IIADKQMKVK EDLDMVEPAV IEAQNAVSSI
KKQHLVEVRA MANPPAAVKL ALESICLLLG EETNDWKKIR QVIIRDNFIT SIVNFNTEEL
SDVIREKMKK NYMSNPSYNY EIVNRASLAC GPMVKWAIAQ LNYADMLKRV EPLRNELQKL
EDDAKENQQK ADEVEQMIRD LETSIARYKE EYAILISEAQ AIKADLAAVE AKVNRSTALL
KSLSAERDRW EKTSETFKNQ MATIAGDCLL SAAFIAYAGY FDQQMRQNLF TTWAHHLQQA
SILFRTDIAR TEYLSNADER LRWQANSLPA DDLCTENAIM LKRFNRYPLI IDPSGQATEF
IMNEYKERKI TRTSFLDDAF RKNLESALRF GNPLLVQDVE SYDPILNPVL NREVRRTGGR
VLITLGDQDI DLSPSFVIFL STRDPTVEFP PDLCSRVTFV NFTVTRSSLQ SQCLNEVLKA
ERPDVDEKRS DLLKLQGEFQ LRLRQLEKSL LQALNEVKGR ILDDDTIITT LENLKREAAE
VTRKVEETDI VMAEVDAVSQ QYLPLSTACS SIYFTMEALN QIHFLYQYSL QFFLDIYHTV
LYENQNLKGV TDHTQRLSII TKDLFQGTFN RVARGMVHND HITIAMLLAK IRLKGLTSEP
SYDLEFHHFL RGREIVLNGS SVSKIDCLTT EQIEGMERLS RLPVFFDLIS KVQVDDQFNI
WLESSSPEQT VPYLWTSEQP LTPIGQAMHR LLLIQAFRPD RLLAMAHIFV AIVLGDSFMS
TIEQPLDLAA IVETEVKPNT PVLMCSVPGY DASGRGEDLA AEQNTQITSI AIGSAEGFNQ
AEKAINTAVK SGRWVMLKNV HLAPGWLMQL EKKLHSLQPH ANFRLFLTME INPKVPVNLL
RAGRIFVFEP PPGVKANMLR TFSSIPVSRM CKSPNERARL YFLLGWFHAI IQERLRYAPL
GWSKKYEFGE SDLRSACDTV DTWLDDTAKG RQNISPDKIP WAALKTLMAQ SIYGGRIDNE
FDQRLLNSFL ERLFTTASFD SEFKLACKVD GHKDILMPDG IRREEFIQWV ELLPDAQTPS
WLGLPNNAEK VLLTTQGTDM LSKMLKMQML EDEDDLAYAE TEKKQRTGST SDGRPIWMRT
LHTTACNWLQ LIPKSLNHLK RTVDNIKDPL FRFFEREVKS GAKLLQDIRQ DLADVVQVCE
GKKKQTNYLR TLISEMVKGI LPRSWVRYTI PADVTVIQWV SDFSERIKQL QQISQAASTG
GAKELKNIHV CLGGLYVPEA YITATRQYVA QANSWSLEEL RLEVTVTNNQ NAVLDACSFG
ITGLTLQGAT CHNNKLSLSN SISTELPLTQ LRWVKETNAE RKANVVTLPV YLNFTRADLI
FTVDFEIATK EDSRSFYERG VALLCTE
//
