ID   A0A401S4Q0_CHIPU        Unreviewed;       814 AA.
AC   A0A401S4Q0;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   RecName: Full=HELP domain-containing protein {ECO:0000259|Pfam:PF03451};
GN   ORFNames=chiPu_0003768 {ECO:0000313|EMBL:GCC25358.1};
OS   Chiloscyllium punctatum (Brownbanded bambooshark) (Hemiscyllium punctatum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Elasmobranchii; Galeomorphii; Galeoidea; Orectolobiformes; Hemiscylliidae;
OC   Chiloscyllium.
OX   NCBI_TaxID=137246 {ECO:0000313|EMBL:GCC25358.1, ECO:0000313|Proteomes:UP000287033};
RN   [1] {ECO:0000313|EMBL:GCC25358.1, ECO:0000313|Proteomes:UP000287033}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=30297745; DOI=.1038/s41559-018-0673-5;
RA   Hara Y, Yamaguchi K, Onimaru K, Kadota M, Koyanagi M, Keeley SD, Tatsumi K,
RA   Tanaka K, Motone F, Kageyama Y, Nozu R, Adachi N, Nishimura O, Nakagawa R,
RA   Tanegashima C, Kiyatake I, Matsumoto R, Murakumo K, Nishida K, Terakita A,
RA   Kuratani S, Sato K, Hyodo S Kuraku.S.;
RT   "Shark genomes provide insights into elasmobranch evolution and the origin
RT   of vertebrates.";
RL   Nat. Ecol. Evol. 2:1761-1771(2018).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GCC25358.1}.
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DR   EMBL; BEZZ01000084; GCC25358.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A401S4Q0; -.
DR   STRING; 137246.A0A401S4Q0; -.
DR   OMA; ICCADFH; -.
DR   Proteomes; UP000287033; Unassembled WGS sequence.
DR   CDD; cd21947; TD_EMAP1; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR   InterPro; IPR005108; HELP.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR13720:SF22; ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 1; 1.
DR   PANTHER; PTHR13720; WD-40 REPEAT PROTEIN; 1.
DR   Pfam; PF03451; HELP; 1.
DR   Pfam; PF00400; WD40; 6.
DR   SMART; SM00320; WD40; 10.
DR   SUPFAM; SSF69322; Tricorn protease domain 2; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000287033};
KW   WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT   DOMAIN          187..258
FT                   /note="HELP"
FT                   /evidence="ECO:0000259|Pfam:PF03451"
FT   REPEAT          538..579
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          667..698
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          779..814
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REGION          74..178
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          31..58
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        120..141
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        152..168
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   814 AA;  89982 MW;  B27511FBEF0583BD CRC64;
     MEDGFSGYSS LYDTSSLLQF CTDDSASAAS SMEMTDRIAS LEQRVQMQED EIQLLKSALA
     DVVRRLNVSE EQQAMLNRKG PTKARPIVQA LPLRPTVNNG TVLPKKGCGS LPSPSGVRKD
     ITPATKSSVK RSNSSERVSS VARRESFGES KNSRTRTGST SSGSSGKKTS DSKPKDPLFN
     AEEGYVKMFL RGRPITMYMP QVIKETYSLE DKGELPAKKL KLDWVYGYRG RDCRCNLYLL
     PTGEIVYFIA SVVVLYNVEE QLQRHYTGHN DDVKCLAVHP DRITIATGQV AGITKDGNQA
     APHVRIWDSV SLNTLHTIGT GFFDRSVTCI AFSKSNGGCT LCAVDDSNDH VLSVWDWQKV
     ERLGDIKCSN EPVFAADFHP TETNVIVTCG KSHIYFWMLE GGSFTKKQGL FEKHEKPKFV
     LCATFAENGD TITGDSSGNI LVWGKGTNRI SYAIQGAHEG GIFALCMLRD GTLVSGGGKD
     RKLISWDRNY QKIQETEVPE QFGPVRTVTK GRGEVLLIGT TRNFILQGTL SGDFHPITQG
     HTDELWGLAS HPNKEQFLTC GHDKHITLWD AVTHQTIWSK IIEDPAQSAG FHPSGCVVAI
     GTQTGRWLVL DTESKDLVTV HTDGNEQLSV MRYSPEGNYL AIGSHDNYIY IYTVNENGRK
     YSRVGKCSGH SSFITHLDWS TDSQYLMSNS GDYEILYWMP SVCKQVVSVE QVRDVEWATY
     TCTLGFHVFG VWPEGSDGTD INAVCRSNDK KLLSTGDDFG KVHLFSCPCS QARAPSHTYG
     GHSSHVTSVS FLHDDSQLIS TGGKDMSVMQ WKVI
//