ID A0A401S6U8_CHIPU Unreviewed; 3966 AA.
AC A0A401S6U8;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=DNA-dependent protein kinase catalytic subunit {ECO:0000256|ARBA:ARBA00018077};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=chiPu_0004494 {ECO:0000313|EMBL:GCC26080.1};
OS Chiloscyllium punctatum (Brownbanded bambooshark) (Hemiscyllium punctatum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Galeomorphii; Galeoidea; Orectolobiformes; Hemiscylliidae;
OC Chiloscyllium.
OX NCBI_TaxID=137246 {ECO:0000313|EMBL:GCC26080.1, ECO:0000313|Proteomes:UP000287033};
RN [1] {ECO:0000313|EMBL:GCC26080.1, ECO:0000313|Proteomes:UP000287033}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=30297745; DOI=.1038/s41559-018-0673-5;
RA Hara Y, Yamaguchi K, Onimaru K, Kadota M, Koyanagi M, Keeley SD, Tatsumi K,
RA Tanaka K, Motone F, Kageyama Y, Nozu R, Adachi N, Nishimura O, Nakagawa R,
RA Tanegashima C, Kiyatake I, Matsumoto R, Murakumo K, Nishida K, Terakita A,
RA Kuratani S, Sato K, Hyodo S Kuraku.S.;
RT "Shark genomes provide insights into elasmobranch evolution and the origin
RT of vertebrates.";
RL Nat. Ecol. Evol. 2:1761-1771(2018).
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family.
CC {ECO:0000256|ARBA:ARBA00011031}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GCC26080.1}.
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DR EMBL; BEZZ01000110; GCC26080.1; -; Genomic_DNA.
DR STRING; 137246.A0A401S6U8; -.
DR OMA; PSPMCRE; -.
DR Proteomes; UP000287033; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004677; F:DNA-dependent protein kinase activity; IEA:InterPro.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05172; PIKKc_DNA-PK; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037706; DNA-PK_dom.
DR InterPro; IPR046804; DNA-PKcs_N.
DR InterPro; IPR046803; DNAPKcs_CC1-2.
DR InterPro; IPR012582; DNAPKcs_CC3.
DR InterPro; IPR045581; DNAPKcs_CC5.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF68; DNA-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT; 1.
DR Pfam; PF20500; DNA-PKcs_N; 1.
DR Pfam; PF20502; DNAPKcs_CC1-2; 1.
DR Pfam; PF19704; DNAPKcs_CC5; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM01344; NUC194; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000287033};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 2716..3379
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 3563..3891
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3934..3966
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
SQ SEQUENCE 3966 AA; 453023 MW; 10F21A64644C562E CRC64;
MADGMRRHGA GVGLEVERRL QQLEQLLSAQ DSRSAAVESH SIVANLTHDL LHNTHESRLA
LHSSLVFSKD EGLLIFLRKS LSNEEFRDCR EEVLKLITAF VEKIKETVGP YALDIKDVCL
VIYTKEKAAK CKVAALDLLL VLLHSKVCLQ EFKIGDMFNK FYGELAQKSK LPDTVLEKVY
ELLGVLAEVQ PTEMLDNSEK LYRAYLNELK IQMTSATRQP KFLVVSGCLR GLIALMVNFT
KSIEEDPRTS KEIFDCAVKA INLKIDIKRY AVPLAGLRLF TLHANQFKTC LLDSYQVLFE
TMSKWCGHTN IEMKKAGYAA LESFLKEIAL QVAEDAHLHK DKLQYFMQQF YSIIRTMESS
TKELSIAIRG YGLFAAPCKA VDSHHVDFMY TELIQRCKQM YLTEADTEDD NIYQLPSFLD
SIASVIFHMD KIPDIYTSVL ERLLVVQIDS FPLYSVRMQP VCCHSIIKLF IALAGKGPVL
WSFISTVVHQ GLIRVCSKPV LLPGEEMTKA EPWSSAQQSL SNGNMGTGKW RVPSYKDYLE
LFRSLLDCGR MKESGLIYET FQMFDSPLKS LNRLLYDEFI KSVLKIIEKL DLSVDKQSQN
EEGGSGDVNS SIVIPTTDPS ANLQPTKPKD FTALFNLVEF CGELLEKHTD FFEHWVYRFG
HELILRSTQF PLVSGFYKLL SVTMKIARKI KYFEGVNPKT RKQCPKNPEK FACFALFGKF
GKEVAIRMKQ YKDELLASCL TFVLSLPYDI IELDIKTFIP ALQTAFKLGL SHIPLADAGL
DALEHWSTRI SKHVIEPYYK DILPHLDGYL KTAASNEFES NWEMMSMNTS SKGGNKVLIR
RLKNARDLSM SEETPAAAVK KRVVRLLGSL GGQINRSLVA ATSSEEMMKK CVAWVAERPL
SFAVPFADMK PVIYLDSFLP RITELALSAS DRQTKVAACE LLHSVVAYML GKGSQIAEGQ
QETMYKLNRH LYPVLLRLGC DVDKVTNQLF EPLVMQLIHW FTNNRKFESR DTVALLEAIL
DGIVDPVDST LRDFCGNCVR EFLKWSIKQT TPEQQQKSPV NTKSLFKRLY SLALHPNTFK
RLGAALAFNS LYREFREESA LVEQFVFEVL VVYVESLALA HADDKSLGTI QQCCDCINHL
KRIIKQKAHE LNKPVKRRVP RGFPADQMVC LTDVVMWLLT QCGRPQTECR HKCMELFYEF
VPILPGARTA SLWLEEILKR NGVSFLVNKF EGAGSDHDNC SGIICHPTLQ ALKEPFSVRA
ALQWMDMLLA ALDCYNTFIG LHLVKPSKIM GTSENSSFLK ALNFFLTNLA RHDVTAAEES
FAYGIKGILF SPREREDYNF NKCTIIVRIM EFVSMVLEDC QQDFLKMLEK YLLNSTLFEL
VATVVIDPPS IGFNMADVQV MKGLPDICVR LMKAALRSPY QESLECSMKK RLKSQSIEDL
CNVDLYSQSD HAKLNSILLA CKQLHKAGLL NSVLKCQIGS IVPPLNLKLL STVYKGIAPG
DERKSLPTMD VSSKMLADGL LQLSFSLGGQ CEELVSLLLN TVELSVPLSG ASQRHFISFS
HGEYFYNLFP ETINSELLRN LNSAVAQLMT SARENPKMVS AVLNGMLDHS FRDHTVRKKQ
GIYLVSAVLS NWAKLDSWWS VKSSPESKMA VLTLLSKVLQ IDSSVSFGNS HDAFSMVFQT
YTTILTDSTL ALNLKTNESS FDNQLTKKIG CYKLFEVMYT RLPKNDVYTD GSKIIQAFHS
AGNIEGNKLS KTLLKSCYDT VTENMTGETQ LLEKRRQYHC AAYNCMIAIL CCIFTEAKFY
QGFLFSEKPE KNIFILENLI DSQRAYNFPV EIEVPVEKKR RYFAIRKEAR ESAEGDSDEP
HYLSSQSYMV DSSLSEEMSQ FDFSTGVQSF SYSSQDPKVS VLRTRKTEWT ESNIMLNDIV
ELEMDEMNQH ECMATMTALI KHMQKTNITP KVEEGKTPHE LPPWMKFLHG KLGNSATPLN
IRLFVAKLIV NTEEIFQPYA KEWLGPLLQL VVSGNNGGDG IHYMVVEIVV TVLSWISVAT
PKGDLKNEIL ANRLLEFLMK NCFHEKRVVF RHNLEIIKTV VECWKDCLSI PYSLIFDRFA
GRDPNTKDNS VGIQLLGIVL ANNLPPYDCK CEIDSERFFQ RLVHNISLTR YKEVYAAAAE
VLGLVLQYLA GKPMDCAVHD LVVKELQQLQ NTKEDKFIVC LSKIVKHFPP FADRFMNAVF
FLMPKLYGIL KTHCLEVVMY RAEEIPDIHI QLKSKDFTQI MSHRDEDRQR VCLDIIYRIK
AKLKSAELKE LLRSVVAFIS HPSPICRERM YDILMWIYDN YRDPESQSDP DSKEIYTETS
DALLQGLTDE NPALQLYVRN FWSHENRLPT GTLDRMLASL GSLYCNKIET QYLSIATNVL
LEMTSHSPDY SREMFEYPLS ECKFQDYSID SSWHQRSRIL TPLFVETQAS AGSIKRSSQE
ASTVDQNTIG GQIRATLTHY EFTPTQNSGA RNFNWLTGSS LDTFAEYTLP FSESASSSLL
VYSKRSERSQ KPMKPVGPDF GQKRLAIPGD EVDAKTKAVA DQRADILRLR RRFLKDRQKE
NLIFARKSIQ EKHLAKEMKT EQLKKRDAQV TLYRCYRVGD LPDIQIKFSS LIAPLQAVAQ
KDHSLAKQLF SSLFSGILEE VRKSKTAAEM SGIGKELLKH FTFLLNTTTL CFPPFVTCIQ
DMSCKHPDLL NLDPSIVSST ALVSLQQPMG IMLLELSLMH LSLPEEPPAK RSRGRTQLPP
DTARWVELAK LYRSLGDYDV LRGIFSEKIG TKSTTQKALL AEAKSDYAEA VQLYDQALNT
EEWVDGNPTD AEKDFWDIAA LECYSHLTEW KSLEYCSTVN ISDKTPVDLE DIWTDPFYME
AYLPHMMRSK VKLLQLGEND QSLLTFVDNA MKVDQRKTVI ETRYSQELSL LYILQDDFDR
AKYYVNNSIQ SFMQNYSSID PLLHRSRLTK LQSLQTLTEI QDFLHFITKG SNLTSEVPLR
KLVRTWIGRY PESKLDPMSV WDDVITNRCF FLDKIKERLS LLQADDSMEV DDEGAETQMD
IDKEEDDITM LIRSCKFNMK LKMLESARKQ NNFSVSTKLL KELHKESNIR IDWRVRWIQS
YSRFSHKRSR SMKRAEQIVT VMKTIPLLGE IDVGNLNIQR HAFRDQNTLL GTTYYIMANA
LNKDPSCLQY IEEERAKNVK KLSGATSDNP VQVSIGLYRK AHEYLQSAVK KAEEEVQSLS
EEHVDTVGVI KAYMTLANFC DRCLREEEES ENINNFPELQ TYPASVVENM LKALQYNSRE
ARLRFPRLLQ IVELYPVETQ DVMTRGVSTI PCWQFIGWIN QMMASLDKKE ACVIQPIIEK
IADSYPQAIV YPFKISSENY TFEPSANGNK NKEFVERLKT KLDKGGVVES FIHSLEQFSN
PDLLFKDWAN DFKTELEKKV KDKKLLKNMY DEMYSNLASL QFPGIGAFRT RYVQVFKKAF
DQYYGKEGSR LLDMNIKIFD EATKKILETV CKKQQAPPGN LKEYSPWMSE FKPEYLRNDL
EIPGQYDGKS KPMPEYHAQI TGFDERIKVM SSIRKPKRLI IRGNDEKEYP FLVKGGEDLR
QDQRIEQLFD IMNIILSRDA ACSQRNLQLK TYQVIPMTSR LGLIEWLDNT CVVKDFLLSN
MTEDEHKRPS PKELFSEWLQ RISGSKSDVT TLYGQMYMKA SRTETVKAFR QCERAVPPDL
LRRAFTKMST TPEAFLALRS HFASSHALMC VSHWILGIGD RHLSNFMINL ETGGMVGIDF
GHAFGSATQF LPVPELMPFR LTHQFLNLML PMKESGLIYS TMVHGLRAFR LDPDLLLNTM
DVFVKEPSLD WKNFELKQLK KEGSWSKDVN INEINWYPRQ KVNYAKRKLE GANPSAITRD
ELQLGHEKSK AYASYVAVAM GDKDHNVRAR ESEEGLSVEC QVDCLIDQAT DPNILGRVWI
GWEAWM
//
