ID A0A401SH42_CHIPU Unreviewed; 800 AA.
AC A0A401SH42;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN ORFNames=chiPu_0008115 {ECO:0000313|EMBL:GCC29673.1};
OS Chiloscyllium punctatum (Brownbanded bambooshark) (Hemiscyllium punctatum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Galeomorphii; Galeoidea; Orectolobiformes; Hemiscylliidae;
OC Chiloscyllium.
OX NCBI_TaxID=137246 {ECO:0000313|EMBL:GCC29673.1, ECO:0000313|Proteomes:UP000287033};
RN [1] {ECO:0000313|EMBL:GCC29673.1, ECO:0000313|Proteomes:UP000287033}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=30297745; DOI=.1038/s41559-018-0673-5;
RA Hara Y, Yamaguchi K, Onimaru K, Kadota M, Koyanagi M, Keeley SD, Tatsumi K,
RA Tanaka K, Motone F, Kageyama Y, Nozu R, Adachi N, Nishimura O, Nakagawa R,
RA Tanegashima C, Kiyatake I, Matsumoto R, Murakumo K, Nishida K, Terakita A,
RA Kuratani S, Sato K, Hyodo S Kuraku.S.;
RT "Shark genomes provide insights into elasmobranch evolution and the origin
RT of vertebrates.";
RL Nat. Ecol. Evol. 2:1761-1771(2018).
CC -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC multimeric enzyme that catalyzes the translocation of protons across
CC the membranes. Required for assembly and activity of the V-ATPase.
CC {ECO:0000256|RuleBase:RU361189}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, clathrin-coated vesicle
CC membrane {ECO:0000256|ARBA:ARBA00029431}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00029431}. Cytoplasmic vesicle, secretory
CC vesicle, synaptic vesicle membrane {ECO:0000256|ARBA:ARBA00004644};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004644}. Melanosome
CC {ECO:0000256|ARBA:ARBA00004223}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GCC29673.1}.
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DR EMBL; BEZZ01000263; GCC29673.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A401SH42; -.
DR STRING; 137246.A0A401SH42; -.
DR OMA; FYLWFFL; -.
DR Proteomes; UP000287033; Unassembled WGS sequence.
DR GO; GO:0030665; C:clathrin-coated vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
DR GO; GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR InterPro; IPR002490; V-ATPase_116kDa_su.
DR InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR PANTHER; PTHR11629:SF68; V-TYPE PROTON ATPASE 116 KDA SUBUNIT A 1; 1.
DR PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR Pfam; PF01496; V_ATPase_I; 1.
DR PIRSF; PIRSF001293; ATP6V0A1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW ECO:0000256|RuleBase:RU361189};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361189};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW Reference proteome {ECO:0000313|Proteomes:UP000287033};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361189};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361189};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 368..392
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 412..431
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 510..531
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 537..561
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 604..626
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 735..756
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT COILED 25..95
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 800 AA; 92026 MW; 85A21C882B059E25 CRC64;
MVQFRDLNPD VNVFQRKFVN EVRRCEEMDR KLRFVEKEIR KANLVILDTG ENPEVPFPRD
MIDLEATFEK LENELKEINT NQEALKRNFL ELTELKYILR RTQQFFDEMS DPDLLEESSS
LLDPSELGRG APLRLGFVAG VINRERIPTF ERMLWRVCRG NVFLRQAEIE NPLEDPVAGG
QVDKSVFIIF FQGDQLKNRV KKICEGFRAS LYPCPETPNE RKEMLAGVNT RIDDLQMVLN
QTEDHRQRVL QAAAKTIRVW FIKVRKMKAI YHTLNLCNID VTQKCLIAEV WCPVTDLDSI
QFALRRGTER SGSTVPSILN RMQTSQTPPT YNKTNKFTYG FQNIVDAYGI GTYREINPAP
YTIITFPFLF AVMFGDFGHG VLMTAFAMWM VLRESRILSQ KSENEIFSTV FSGRYIILLM
GIFSVYTGLI YNDCFAKTLN MFGSSWSVRP MFQPTGNWTE KTLQGNQHLQ LDPAQPNVFN
GPYPFGIDPI WNIATNKLTF LNSFKMKMSV ILGVVHMVFG VSLSLLNHIY FKKPLNIYFS
FIPEIIFMLC LFGYLVILIF YKWTAYDAST SKDAPSLLIH FINMFLFSYN DKTMKYLYKG
QRGLQSFLVV VALLCVPCML VVKPLILRHQ HLRRKHLGTH NFGGIRVGNG PTEEDAEIIQ
HDQLDTHSED GEEFNFGDVA VHQAIHTIEY CLGCVSNTAS YLRLWALSLA HAQLSEVLWT
MVMHIGLSIN NFGGSFLLFF IFAAFAVLTV AILLIMEGLS AFLHALRLHW VEFQTKFYSG
SGYKFVPFSF ESILEGKFEE
//