ID A0A401SJ55_CHIPU Unreviewed; 560 AA.
AC A0A401SJ55;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE RecName: Full=Ras-GEF domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=chiPu_0008883 {ECO:0000313|EMBL:GCC30432.1};
OS Chiloscyllium punctatum (Brownbanded bambooshark) (Hemiscyllium punctatum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Galeomorphii; Galeoidea; Orectolobiformes; Hemiscylliidae;
OC Chiloscyllium.
OX NCBI_TaxID=137246 {ECO:0000313|EMBL:GCC30432.1, ECO:0000313|Proteomes:UP000287033};
RN [1] {ECO:0000313|EMBL:GCC30432.1, ECO:0000313|Proteomes:UP000287033}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=30297745; DOI=.1038/s41559-018-0673-5;
RA Hara Y, Yamaguchi K, Onimaru K, Kadota M, Koyanagi M, Keeley SD, Tatsumi K,
RA Tanaka K, Motone F, Kageyama Y, Nozu R, Adachi N, Nishimura O, Nakagawa R,
RA Tanegashima C, Kiyatake I, Matsumoto R, Murakumo K, Nishida K, Terakita A,
RA Kuratani S, Sato K, Hyodo S Kuraku.S.;
RT "Shark genomes provide insights into elasmobranch evolution and the origin
RT of vertebrates.";
RL Nat. Ecol. Evol. 2:1761-1771(2018).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GCC30432.1}.
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DR EMBL; BEZZ01000302; GCC30432.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A401SJ55; -.
DR STRING; 137246.A0A401SJ55; -.
DR OMA; QAYATTQ; -.
DR Proteomes; UP000287033; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd13310; PH_RalGPS1_2; 1.
DR CDD; cd00155; RasGEF; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF357; RAS-SPECIFIC GUANINE NUCLEOTIDE-RELEASING FACTOR RALGPS2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00617; RasGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000287033}.
FT DOMAIN 50..288
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT DOMAIN 434..546
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 284..314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 284..311
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 560 AA; 62992 MW; 460D225076FFBD4F CRC64;
MDLTNGQSSA IYFTATASER SSSSESLSEK ASNDPKKSFD AVVFDVLKVT PEEFASQITL
MDAPVFKAIQ PEELSSCGWN KKEKHSSSPN VVAFTRRFNH VSFWVVREIL TAQTLKIRAE
VLSHYVKTAK KLYELNNLHA LMAVVSGLQS APIFRLTKTW ALLSRKDKTT FEKLEYLVSK
EDNYKRLRDY VNSLKMTPCI PYLGIYLSDL TYIDSAYPST HSIIESEQRS NLMNNILRII
SDLQQSCDYD IPLLPHVQKY LNSVRYIEEL QKFVEDDNYK LSLRIEPGTS TPQSTASRED
LAGSDAAPSP QSSRRYMAAE AALTNVPPTP PSSRHLLTHG HRKSHSLGYN FIHKMNTVEF
KSATFPNGRP RHLLDDSVME NYTPSRVQAE SSTISSGISI GSSEGSELSE DVSWPAFESS
VESEELAVNL FPGTVTIQGV LRRKTLLKEG KKPTVASWTK YWVALCGTKL YYYSAKSLKP
TERKHFKSSL SKSVSVVGWM VMMADDPEHP DVFQLTDSER GNSYKFQAGN RGNAMLWFKH
LSSACQSNRQ QVPANLMSFE
//
