ID A0A401SJ83_CHIPU Unreviewed; 4680 AA.
AC A0A401SJ83;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Hemicentin-1 {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=chiPu_0008909 {ECO:0000313|EMBL:GCC30458.1};
OS Chiloscyllium punctatum (Brownbanded bambooshark) (Hemiscyllium punctatum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Galeomorphii; Galeoidea; Orectolobiformes; Hemiscylliidae;
OC Chiloscyllium.
OX NCBI_TaxID=137246 {ECO:0000313|EMBL:GCC30458.1, ECO:0000313|Proteomes:UP000287033};
RN [1] {ECO:0000313|EMBL:GCC30458.1, ECO:0000313|Proteomes:UP000287033}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=30297745; DOI=.1038/s41559-018-0673-5;
RA Hara Y, Yamaguchi K, Onimaru K, Kadota M, Koyanagi M, Keeley SD, Tatsumi K,
RA Tanaka K, Motone F, Kageyama Y, Nozu R, Adachi N, Nishimura O, Nakagawa R,
RA Tanegashima C, Kiyatake I, Matsumoto R, Murakumo K, Nishida K, Terakita A,
RA Kuratani S, Sato K, Hyodo S Kuraku.S.;
RT "Shark genomes provide insights into elasmobranch evolution and the origin
RT of vertebrates.";
RL Nat. Ecol. Evol. 2:1761-1771(2018).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GCC30458.1}.
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DR EMBL; BEZZ01000303; GCC30458.1; -; Genomic_DNA.
DR STRING; 137246.A0A401SJ83; -.
DR OMA; RIYRVQP; -.
DR Proteomes; UP000287033; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 7.
DR CDD; cd00096; Ig; 11.
DR Gene3D; 2.40.155.10; Green fluorescent protein; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 40.
DR Gene3D; 2.10.25.10; Laminin; 7.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 4.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR006605; G2_nidogen/fibulin_G2F.
DR InterPro; IPR009017; GFP.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR10075; BASIGIN RELATED; 1.
DR PANTHER; PTHR10075:SF109; FASCICLIN-2; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF07645; EGF_CA; 5.
DR Pfam; PF07474; G2F; 1.
DR Pfam; PF07679; I-set; 30.
DR Pfam; PF13927; Ig_3; 9.
DR Pfam; PF00090; TSP_1; 5.
DR SMART; SM00181; EGF; 7.
DR SMART; SM00179; EGF_CA; 7.
DR SMART; SM00682; G2F; 1.
DR SMART; SM00409; IG; 38.
DR SMART; SM00408; IGc2; 38.
DR SMART; SM00406; IGv; 12.
DR SMART; SM00209; TSP1; 5.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF54511; GFP-like; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 39.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 5.
DR PROSITE; PS00010; ASX_HYDROXYL; 4.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS50835; IG_LIKE; 39.
DR PROSITE; PS50993; NIDOGEN_G2; 1.
DR PROSITE; PS50092; TSP1; 5.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000287033};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 1..85
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 143..233
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 240..324
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 331..417
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 429..511
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 520..606
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 610..701
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 706..792
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 799..888
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 893..981
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 986..1075
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1080..1167
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1171..1251
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1289..1375
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1380..1470
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1475..1564
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1569..1658
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1663..1751
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1756..1847
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1851..1946
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1950..2056
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2060..2149
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2155..2241
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2248..2338
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2342..2381
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2398..2488
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2493..2582
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2587..2674
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2679..2767
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2770..2858
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2863..2949
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2954..3042
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3047..3131
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3138..3223
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3226..3312
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3317..3405
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3408..3480
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3497..3581
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3588..3675
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3962..4184
FT /note="Nidogen G2 beta-barrel"
FT /evidence="ECO:0000259|PROSITE:PS50993"
FT DOMAIN 4242..4281
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4324..4359
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4367..4407
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4480..4519
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 4484..4494
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:GCC30458.1"
SQ SEQUENCE 4680 AA; 509492 MW; 11C9B62C9D1F4387 CRC64;
HVTVIPSSRT FLRAMEVQIH CTVTGYPDPE VVWIHKDSLV TNNDRFVINE FGTLIIKDAV
PKDAGSYTCL ASNSVGTDKG EAKLKYLGDL ELALVPFTEI DPVHGTLWIR KVQQVDAGEY
TCVASNEAGR SSATIMLDVG SAPLFLEMPS DMSVTIGKNV TLLCSAVGEP VPQVTWRRLD
GQPIFSKTDS MSFVSQLETG SLFIEGVWLD DEGMYVCEAQ NLFGVIRSEV ALTISGLVAP
EVVESAPVIN VLEGRSLTLP CVVLAGNPFP EHYWLKDNQL LSLDSRLSIR SDGSFFIERT
EQGDAGKYIC TIRNVVGSVN KTITVYVHVL PSIKHGQTVY ITNEGVAVTL LCESSGTPKP
TVVWSKGKEL ISRHEPQYSI DASGKLLIPY PSAEDSGIYI CTATNVAGVS SREMQLFVHT
KPQIDGVNPD NLDKPIKITA TAGTEVTLPC EVQGSPPPII RWKKDSRLVP LVSARYTVLP
LGSLMILDSR ASDSGLYKCS AINRAGNASL TLQLIVQVPP KIHLSHHLLK VIVGQSIDLP
CLAHGDPTPK IRWYKDDEAL LQGATDSLDG PDGSINIADV ELSDAGIYRC EATNNAGHDM
TQMTLEVLEP PFFAEDIALI NAEQERLARD KVILPCPVNG TPPPVIRWLK NGLDLLAHEP
GISVLEDGSL LIDSASPYDS GDYLCVAMNE AGSSKRKYRL NVQAPPEIRG NGQVQNITVS
VNQPLMLECD ASGSPTPTLS WYKNEQQVTE TSRVRLLNGG QVLRLSKSRK GDSGVYSCNA
VNVAGTAKKY FNLLVQVPPS IYGSGVTQEV AILVNSKLEL TCRANGVPFP HIAWNKDGEA
LSPGVQYVEF TEEGQTLHIQ TSHLIDQGLY QCVAFNPAGQ KSKHFKVNVY VPPTIQGVND
TKEVIAQLKS HVSLQCDAHG IPAPGITWLK DGRPIVSSSK MTYVERGQFL LINEVQASDQ
GWYTCRARNI AGSMEKSYRM QVYVPPRIEG RLHHPLKTKA IVGHSLTLTC SSSGYPPPVL
SWLKDGVSLT DSDRIQLMGE GKTLKIENVR ESDAGTYTCM ATSAAGEEHL QYTVDILVPP
QLLIEESSHV TVTIDNPLEL ACKVTGNPPP KITWLRNNIM LTELDGAQVS AHGSKLFIPR
LKSVDVGRYV CVARNEAGER RREFNVTIHV PPVVTIVGVE NLVIVVGKSA ILECTATGIP
TPSISWLKNS QLLTETSGRL KIEKVTQQDE GIYSCIATNG AGESQQDTRV TVYEPPVINK
SVDTNKTVTM NLPASFECLA SGTPPPVPPS ILGEEQNVSV TLNDYISLDC QSQAFPPPTL
RWTKDGQPLP MRADHRLSEN ASLFEIKSAQ IQDAGRYTCE ASNNAGKTEK NYNLHVWVPP
TFYGLKEQIS VTVIEGNTLS LFCDCIGIPY PTLEWQKNGK PLSTVKDDRI TVSSGSQMLQ
IARTRISDAA NYTCIGTNLA GTNKQDYSVE IYVMPSIKNG GRQPTEISIA RGAEITLECE
ADGVPWPTLT WVKDGRPVVS RRGIQVENEG RSLKIQRAQE DNTGRYTCLA INVAGQSDRK
FDLSVHVPPA IIGEIGAPEN ISTLLSNSIS LICEATGVPP PVFTWFRNGS PIVSSTRMQI
LSGGRTLKLT RVLMGDAGHY SCVASNSVGE AAKDFHVDVL SPPSILNENQ VEKVEVKQKQ
DINMTCLTTG NPKPQVTWLR DGQELNDSTD YRVSSDGSVL EIFKATLSHT GQYTCVASNS
VGDKSINYHL SVLVTPRIPN LGEDGTPEDV IVIVNNPTSL ACEAEAYPSP TITWLKDGIP
FKASRNIHLL PGGRGLQILN VQEENAGRYS CVVTNIAGEA VKDYELKVFI PPVIAKDDQT
AGGFRVTQVK TKVNTTLTLV CESWATPVPA LRWYKDGQLL TGTEHLQILD KGRILQIRYT
RVSDTGRYTC VATNIAGEDE KDFHVNIQVP PIFQKLYGVN AAWEVINRVD EAEEIVEHRE
VIVNNPVSLY CETNAIPPPI LSWYKDGEAL SATDDVLILP GSHILQIPRV RADDAGRYTC
RAVNEVGEDQ LHYELVILIP PVIHSEGGEF GEELVSVVNK TVKLHCEAAG KPPPSIFWFR
DSLPIATDSR HQLLDNGSIL QIHAVQASDA AGYICLAENS AGSTKKLFSL RVQVPPMLLG
PSPENVSVVM NNPIWLTCEY RALPSADIEW YKNGQLLQSR TDMLILPGGH ILHIPRAKTE
HNGNYVCVAT NAAGRDMKDI HLHVYLPPSI KYHGDSYSEA ITIRAGETAT LRCESEAVPV
PTVMWYKNDH HLALVNGTHI LSDGQILQIQ DAQVTDSGHY MCNVANLAGQ MKRTFRLNVH
SPPTFEEPLE EVINQTAGKA FGLSCQPLGV PPPTITWLKD GEPLEVRKHF SLFIQVPPSI
LGSTVPTEYD AIENEDVKLE CVTTGEPKPI LKWFKEGQPL ETLTKAHFNL TSDGSSLDVK
GVLVSDTGKY TCVAWNPAGE ETKMYILNVL IPPNISGVSS HPEIITVVPN AAVTLECRAA
GTPPPQLTWL KDGLPLPISS HVRLLLAGQI LRIAHVQISD AGTYTCVAVS QAGMTQRHYQ
LQVQVPPRFE NSGDSEETMV IRGASVSFTC DTGGIPPPVF SWLKDGELLV LNDLSLKSHE
MKLHLPSVDR SDSGWYSCIA VNDAGKATRH FNLVVMEPPQ ISDSEMPQEV SVVLSSLLEL
VCTAIGIPAP EISWMKDGVP LDGTGSVLND GKVLRIERVQ VEDAGLYTCL AANLAGEDQL
QYLVRINVPP NIIGSSDAQM VTLLAEEQLT LECKSEADPP PVVQWFKDDV LLQANAHIQN
VPDRRYLLID NVGPSDAGMY SCLLSNIAGQ MTHSFNVIIH VTPTIKANSP SLSVIINQVA
LLECEAEGIP KPTVTWRKDG NLLPTGSPRF DFLSEGSLQI HSVQISDAGH YLCTASNAVG
TDHHRIELQV LDAPIISPAP TNITALANVQ AELSCEVSGT PKPEVIWKKN GKPLNFKLQQ
NMYRLLPSGS LVIISATTQD TALYECVVSN EAGDSQRLIQ FTVHVPPSIA DDSPNVTITK
MSSVVLTCHA TGIPEPAVSW MKDGAQMGNR GPGYKILPTG SLEVTTATLS HAGSYMCTAR
NVVGTAHRHV TLIVQEPPVI KPLPSTVETV VNRGIILPCE STGTPRPSIT WQKEGATITN
TGYLLLANGA LEITRATEEY SGNYMCIAQN PAGTALGKTK LVVQVPPIIK AHSREYKATI
DHPATLPCEA EGHPKPEVTW VKDGRTIANQ MRLQTFANGS LQILPIQLAD AGWYTCVARN
KAGVVSLDTI LVVQVPPSIV IGQLELSVLE DSQALLPCVA QGSPAPVVYW EKDGVAVPDV
SGKFTALQSG ELIVENTTPE DAGVYTCTAV SAAGKASHDI RLFVSVQPAF TELPADVSLH
KGERLLLTCA AKGLPIPLIS WNFNNKPITA KDSGKEGRSE LIIEKVSKEH SGTYVCTAES
DVGMIKAVGF VYVKEAPVLH GEVTAYQTEP LGGNVVLNCD AHGDPAPSIN WNKNGRPLTV
SNRIRQMNNG SLAIYGTVNE DAGDYKCVAE NEAGVVERKV TLMLQSAPVF TVEPLDTVVS
VGDRVLLHCQ AAGEPSPTVE WTKNGHPIRE NGRLVVLQNS TLQILSAVKE DTGEYECVAR
NLMGSSFVGI TVTVQVHGGF SEWLNWGPCS VTCGQGIKER IRLCNNPLPA NGGRSCHGWD
VESRQCNAKP CPVHGQWSLW GAWEGCSQSC GQGNQTRRRS CSDPPTQHGG RPCEGKATEV
KKCIFVPCPV DGQWTAWNSW SRCSASCGGG VHQRTRSCFD PPPQYGGNLC EGSDVDVVLC
NNEPCPVNGN WGSWSSWNPC SQTCGGGQSK RYRSCGNPAP ANGGNICSGV NVQMQRCGID
LCPVNGGWSP WQPWSECSAS CGGGTQLRKR QCNSPPPNGN GRGCPGESFQ TASCSYHPCP
GVPGRARGSL IGIINDKEFG IAFLDANITA NAAAGTTTLQ ANIQNIPSTI GPLVRVLASV
FTPIYWSVAF PAPGTANGFT LTKGVFRQES QMEFATGEIL RMTHVARGVD TDGVLLFDVV
INGYIPRNIE SADIAVKDFS EKYVQTGPGQ LYVSSTQTFL NNGSPVSFHC NHTIEYESGM
GNQPSPFQIL KAEYISVFYN VKMEELNFRI TVSFQKGSTE GQCPRGYILD SSSYCTDIDE
CQLGIHMCHF GQNCQNEAGS YRCLVRCGIG FKQSAEGAQC EDINECEESA NPPCQQRCLN
AVGTYRCGCD PGYQRRGQHC VDINECNMNV CRPDQECQNT EGGYQCTESC PHGTTRLPSG
TCGDVDECKT GDHLCRYNQK CENTAGGYHC SCPHGYRSQG VGRPCLDVDE CQQIPKPCVY
QCRNLVGSYK CLCPPGKQLQ GDAKSCAGLE KPKLSNSTIT SFRPQLVSIS QYSHSQQTSQ
NQINPFYTWL GWKMNREHET QDNRKSCPTG YRKRNGVCTD INECQTWHFC QHDCKNTQGS
YRCICPSGYR LLPNGRSCQD IDECQEQNIK CGLNQMCFNM RGSHQCIDTP CPASYRRGPS
PGTCYRRCIL HCSAGPLAFQ YKLLTLPRGI PAKHDVIRLS AFSERGVLQS RTNFTAIEQD
VASPFAIRTD QGRGIVHTLH PLMESRVYRL KVHATTFSEQ GPLKYHSVFV IVIAVSPYPY
//
