ID A0A401SMJ2_CHIPU Unreviewed; 3967 AA.
AC A0A401SMJ2;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE RecName: Full=VWFC domain-containing protein {ECO:0000259|PROSITE:PS50184};
GN ORFNames=chiPu_0010046 {ECO:0000313|EMBL:GCC31586.1};
OS Chiloscyllium punctatum (Brownbanded bambooshark) (Hemiscyllium punctatum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Galeomorphii; Galeoidea; Orectolobiformes; Hemiscylliidae;
OC Chiloscyllium.
OX NCBI_TaxID=137246 {ECO:0000313|EMBL:GCC31586.1, ECO:0000313|Proteomes:UP000287033};
RN [1] {ECO:0000313|EMBL:GCC31586.1, ECO:0000313|Proteomes:UP000287033}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=30297745; DOI=.1038/s41559-018-0673-5;
RA Hara Y, Yamaguchi K, Onimaru K, Kadota M, Koyanagi M, Keeley SD, Tatsumi K,
RA Tanaka K, Motone F, Kageyama Y, Nozu R, Adachi N, Nishimura O, Nakagawa R,
RA Tanegashima C, Kiyatake I, Matsumoto R, Murakumo K, Nishida K, Terakita A,
RA Kuratani S, Sato K, Hyodo S Kuraku.S.;
RT "Shark genomes provide insights into elasmobranch evolution and the origin
RT of vertebrates.";
RL Nat. Ecol. Evol. 2:1761-1771(2018).
CC -!- SIMILARITY: Belongs to the FRAS1 family.
CC {ECO:0000256|ARBA:ARBA00005529}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GCC31586.1}.
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DR EMBL; BEZZ01000375; GCC31586.1; -; Genomic_DNA.
DR STRING; 137246.A0A401SMJ2; -.
DR OMA; NSGMRVQ; -.
DR Proteomes; UP000287033; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR CDD; cd00064; FU; 11.
DR Gene3D; 2.60.40.2030; -; 5.
DR Gene3D; 6.20.200.20; -; 4.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 1.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR039005; CSPG_rpt.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR45739:SF1; EXTRACELLULAR MATRIX ORGANIZING PROTEIN FRAS1; 1.
DR PANTHER; PTHR45739; MATRIX PROTEIN, PUTATIVE-RELATED; 1.
DR Pfam; PF16184; Cadherin_3; 12.
DR Pfam; PF03160; Calx-beta; 5.
DR Pfam; PF00093; VWC; 5.
DR SMART; SM00237; Calx_beta; 5.
DR SMART; SM00181; EGF; 8.
DR SMART; SM00261; FU; 14.
DR SMART; SM00214; VWC; 6.
DR SMART; SM00215; VWC_out; 4.
DR SUPFAM; SSF141072; CalX-like; 5.
DR SUPFAM; SSF57603; FnI-like domain; 4.
DR SUPFAM; SSF57184; Growth factor receptor domain; 5.
DR PROSITE; PS51854; CSPG; 12.
DR PROSITE; PS01208; VWFC_1; 1.
DR PROSITE; PS50184; VWFC_2; 6.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000287033};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 3865..3886
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..54
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 59..119
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 123..183
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 185..245
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 249..309
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 313..384
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT REPEAT 1067..1162
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1182..1271
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1293..1404
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1431..1527
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1562..1656
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1677..1773
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1796..1898
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1919..2019
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 2040..2139
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 2161..2253
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 2273..2366
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 2401..2498
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
SQ SEQUENCE 3967 AA; 442853 MW; 507ED75DA0E4B0EC CRC64;
MVNNTVWKPD SCQDCSCHSD IVLCELTQCR NPQCDFQKGE VFKISPNNCC PECALRTQSF
CEYEGQVHGH ETEWMTSRCT ICSCANKKVE CGPKYCPSIT CGRGEIEYTP EGDCCPKCVK
TGESCLYEGR MYRDGEDWNL TNCSKCVCSN GEVQCYIAEC QLLYCKKDED VVMQVGNCCP
ECLPKSCSLA GKRYKHGNQW KKNDCTSCIC DRGEIRCHAQ LCPSLTCEKG LNKIRRPGRC
CEECVSGKGS CLYEGVTRYH GEMWNVTSCE FCMCERGQVI CQTAECARVK CSRGEELLHL
PGKCCPECVS LGSYCIYKEQ VKEAHHSDLK GEKHLQNGEK WKEGPCKECE CRNSQVICYK
RSCPLCPVGT LAVKIKGECC PECQPVQCHA DCLTCTHSPD HCDICSDKSK FLQHGRCLQS
CQPGFYKEGR LCKACDKTCA TCQNEFECIS CKEPLLMEFG QCVPSCGEGL FQDQLQCSAC
HKSCLICHGP SETDCVQCRD QSHLLKAGVC VANCGPGYFI KDGHCHACDS SCLTCYHDNP
KCLTCSEGKV MHNGKCASHC PDGYYKDVAS RCAACHISCS TCTGSSEHCT SCSNHFSRHK
GQCLVACPEG FYSENGVCQA CSHPCRACVG PKQSDCTNCL KPEEVIQIQE DSHEVPHGEC
VAHCKSHFYM NSAKVCTECH ATCTSCTGSS PQNCTACSPP RVLYENKCLH TCPEGFYRHD
DACYSCYPSC KQCDGPSDSD CLTCHPHVTL LNGYCRTSCR EGQYLNQVGY CVDCQPQCQH
CTADLKDTGS VCLYCKNPSE MLLGDTCISQ CPVGYFMSRG TCKRCHSSCK ACSTEGAYGC
TACAANLVLA ETGQCVTSCP PAFYSDNQQI CRACNSQCLT CESNSACLSC KDPTKVLLFG
ECQYEVCAQQ YYIDYLTGTC RECDWSCNAC KGPLKTDCLQ CMDGHVLQEG SCVEQCAAGF
YKAGEECIRC DERCVKCSSP GVCSQCESPY LLLETQCVHD CGKRYYSDHS QQKCIACSPG
CLECDRTLQC KLCDSSNFLK NELCVPDCGP GYYGNMSKRI CKVNIYAPVL HANRSVNVGI
GGSQVLDPTY MDIYDADTPT EDLILHIVNP PDNGRLIKMA KGKQIHLQKG DTFTMQELRK
HNILFIHDKK KSRKGQFTLK ASDHQLYSFP ETISIQALSL KGPYVLNNKV LLLGRGELGT
ISNLILDIQD DDNPSEVVLT VLDPPEHGRL LLHPADVSVQ QFQLKDLKSG QLHYVHDGTN
SLHDQVLLQI NDGHNILNIL FQIKITEQKF DKGPQLLNNV RGWVTEGGLL QITNRLLQAA
DKDASDSEII FNLIQEKEIP KFGDVILLVP MPADGPADGW QRLPDGKTAT ATNSFSQQDL
NDGIVWYQHS GVTSAEDSFR FQVTNGGRTY TGTESHIFEI GILPKNENGP HLASNIITPL
QITALEDRVT VIQSTQLSFV DSDTPNQDLF YNITVPLPPE YGTIEHSDSP LFPVTFFTQA
DIDHGKILYR PPGSSSHVQG FFKFSFTGLP ESVNFLFTVS DGEHTSPEMV FTIHLLSTNQ
QPPVFQISEP FLEVSQGGRA TIGLTQLAVR DADTYPDDLL FELLEPPQFG VLIKSDNRQP
LVKGDTFTHD DVARNAIHYI HGGTPTTQDG MQILVTDGVT TATTLLEVHI SAIDGDGPRL
APESLLTISV PAKSFETLTR SHLAYTDNNS PDSKIRMQLI SLPMYGILTN QDEELLEFST
FTMEDIDNQR IRYTTDFDIE DQPITDIFHF TVYDADNNRL DNQMFTITIT AAESYSPLVN
VRDEVTVEEG GRILLSSHSI LATDPDTPEK DLLIKITSAP TFGYIENLKR DGRTDQAVII
SPDVPFSVQD ILNNNIYYVQ SVHRNIEPVS DSFDFYVTDG TSQSPVYNFN IKILRKNDEP
PKMNVEAVYV NEGAGVVIRN SSLSLLDLDT PENELVLRVT KKPSHGKLRK RQFYSEPLEN
GRVLTQGSSF TYQDVLDELI VYTHDGTSVQ SDEFRFAFTD GLYTENGKME FFVEKQKNEA
PRLAINRGLQ FSAGSVSVIT QQHLKATDID SDDEKLTFVI TKDPTVGRLQ MSKNDNLVQI
SIRGPIKRFT QADINKGYVE YRHEKGEPGG SFAFKFDVVD TDGNKLIDQS FFISVLEDKL
PPSIVVNKGL VLEENTVKKI TTLQLSATDQ DSEPGELMYR LTKQPQLGHI EHVASPGTKV
SYFTQADLAA RSIQYVHTSD EEKHSDDFTF SVSDGVNEVS QAFYITIRPV DDALPVVQIP
GMRVQEGVRK TITEFELKAT DADTEAESLT FVIVQQPRHG TIERTNNGHH YRQTNTFTMD
DIYQNHISYN HDGSNSLKDR FSFSVSDGTN PFFIVEEAGK EILTAAPQKF KIDILPVDDG
TPRIVTNLGL QWLEYMDNKA INLITKRELL TIDPDTEDKQ LVYEITTEPK HGHLENKLRP
GIPLKSFTQE DINLGLICYI LNEDMIQKTM DTFKFLVKDS KPNIVHDNVF HIQWSLISFE
YTSYNVSEKA GSISVTVKRS GNLNQYAIVL CRTEQGSATS TSGAGSKLGQ QDYVEYAGQV
QFDEREDTKA CTIIINDDQV FENLESFNVE LSMPAYALLG KITRAKVNIN DTEDEPTLQF
DKKLYRVNES AGFLFVPVER KGDTSSTVSA ICYTIPKTAK GSSLYALESG SDFKSRGMTN
ENRVIFGPGV SMSTCDVQVI DDSEYEEEED FEITLADASY NARIGEAATA KVIINGPNDA
SLVFLGNSSF TVSEDAGTIE IPVIRHGSDL STPTSVWCAT HPSDPPSATP GIDYIPSSKK
IDFAPGKTEE TCTLTILDDV QNPIIEGNET FIVFLSSAQG AELTKPYQAI VAINDSYQDV
PSMQFGKNIY RVKEKEDELH VPIIRTGDLS YESSVRCYTR QLTAEVMEDF EERRNSDDSR
LTFQKGEKVK NCTILINDDT IFEPEERFQL HLGNPLGNHW SGAKVGKNDV ATVTISNDED
APTIEFEEAT YQVHEPPGPD GIAILNVKVI RKGDQNRTSK VRCSTRDGSA QSGIDYNPKS
RVLKFSPSID HILFKVEILS NDDREWHESF SLVLGPDDPV EAILGDITMA TVTILDQEAA
GSLILPAPPI VVSLVDYDHV EEVTKEGTKK NPSPGYPLVC VTPCDTHFPK YSAMKERCDE
AGINQSTVRF SWEVATPTDT SGARSPFETV TDTTPFTSIN HMVLDSIYFS RRFHVRCVAK
AVDKAGHVGT PLRSNIVTIG TDSSICHTPV VAGTARGFQA QSFIATLRYL DVKHKEHPNR
IHISVQIPHQ DGMLPLVSTM PLHNLHFLLS ESIYRHQHIC SNLVTLKDLR SITDSGFLDD
VNYDSITLGP GYDRPFQFDP NVREPKTIQL YKHLNLKSCI WTFDAYYDMT ELIDVCGGSV
TADFQVRDSA QSFLTVSVPL YVSYIYVTAP RGWASLEHHT EMEFSFFYDT VLWRTGIQTD
SVLSARLQII RIYIRDDGRL VIEFKTHAKF RGHFVMDHHT LPGQKSQIVA PDHLGGIEFD
LQLLWSAQTF DSPYQLWRAT SSYNRKDYSG EYTIFLIPCT VQPTQPWIDP GDKPLACTAH
APEKFLVPIA FQQTNRPVPV VYSLNTEFHL CNNEKVFMMD PSKTEMSLAE MDYKGAFSMG
QKLYGRVLWN PEQNLNSAYR LQLEKVYLCT GKDGYVPFFD PTGTIYNEGP QYGCIQPNKH
LKHRFLLLDR NQPEVTDQYF HDVPFDAQFA SDAPEFLTMR DVPGVDGFTM KVDALYKVEA
GHQWYLQVIY IIGPESLSGP RVQRSLNYRF SRRRRDLVDK NGKLTLDDSL IYDNENDQVK
NGTNMKNLRL ESEAVALTSH KEASIGGAVA AIMLLLLFLI TACFLARKCK HKKLPKEIPE
EYPLNTKVEI CNKALNRLEK NLNGKHCTEK NINILNKNDI IRVKGVKVKQ VNLNVKLQNN
LQDGTEV
//
