ID A0A401SPE3_CHIPU Unreviewed; 1122 AA.
AC A0A401SPE3;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=G-protein coupled receptors family 3 profile domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=chiPu_0010736 {ECO:0000313|EMBL:GCC32275.1};
OS Chiloscyllium punctatum (Brownbanded bambooshark) (Hemiscyllium punctatum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Galeomorphii; Galeoidea; Orectolobiformes; Hemiscylliidae;
OC Chiloscyllium.
OX NCBI_TaxID=137246 {ECO:0000313|EMBL:GCC32275.1, ECO:0000313|Proteomes:UP000287033};
RN [1] {ECO:0000313|EMBL:GCC32275.1, ECO:0000313|Proteomes:UP000287033}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=30297745; DOI=.1038/s41559-018-0673-5;
RA Hara Y, Yamaguchi K, Onimaru K, Kadota M, Koyanagi M, Keeley SD, Tatsumi K,
RA Tanaka K, Motone F, Kageyama Y, Nozu R, Adachi N, Nishimura O, Nakagawa R,
RA Tanegashima C, Kiyatake I, Matsumoto R, Murakumo K, Nishida K, Terakita A,
RA Kuratani S, Sato K, Hyodo S Kuraku.S.;
RT "Shark genomes provide insights into elasmobranch evolution and the origin
RT of vertebrates.";
RL Nat. Ecol. Evol. 2:1761-1771(2018).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GCC32275.1}.
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DR EMBL; BEZZ01000422; GCC32275.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A401SPE3; -.
DR STRING; 137246.A0A401SPE3; -.
DR OMA; FTSCEPI; -.
DR Proteomes; UP000287033; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR Gene3D; 3.40.50.2300; -; 4.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24061:SF0; VOMERONASAL 2, RECEPTOR 23-RELATED; 1.
DR Pfam; PF01094; ANF_receptor; 2.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00592; CASENSINGR.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000287033};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1055..1077
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 13..416
FT /note="Receptor ligand binding region"
FT /evidence="ECO:0000259|Pfam:PF01094"
FT DOMAIN 457..511
FT /note="GPCR family 3 nine cysteines"
FT /evidence="ECO:0000259|Pfam:PF07562"
FT DOMAIN 617..1017
FT /note="Receptor ligand binding region"
FT /evidence="ECO:0000259|Pfam:PF01094"
SQ SEQUENCE 1122 AA; 124339 MW; 60CE04B998339B94 CRC64;
MYCESFDISS FRLMQTMIFA IEEINRSKNL LPNITLGYEI YDDCSTSAIA SKAALVLVNG
EEELIEYPDC KGSSNVAAII GCDISTSSIT AARTVGAFGI PMISYFSTCS CLSDKQEYPT
FFRTIPSDKH QSKLLAELVK TFGWNWIGTV RSNTDYGNFG MRTFVKEAQK IGICIAYSES
FHRTDSAKKI HKIVQVMKEA TTKVVVGFLH GTDMRVLIKE ILRQNVTGIQ WIGSEGWITE
DIFSPEERVG FLTGAIGPAT RRTEVAGLRD HLLKIHPSRF PESVFVKTFW ETLFSCSLTK
GNETETRSST FQVRSCTGNE HLNGLENAYL PAIMDGSSYH VYKAVYAVAH ALDDMLSCEE
GNGPFMNNAC AHISRFQPGQ LLHYLQLVNF TAKTGEVVYF DENGDPVPTY DIVNLQMRTE
SSLEIVNIGY YEGSAPEGEE LVLNTDDIMW SSTDKQIPRA LCSEPCSPGT RKVSRKGQPI
CCFDCAECGD GEISNTTDSI DCVKCPLEYW SNQQKDRCVP KKIEFLSFQE VLAYVLVALA
LVGVCLALGT AAESPGMVCK SRGKGGLPNL SEDGDIIVGG IFAAHLDVIH DIPSFAVSPS
DTYCESFDIA SFRLIQTMIF AIEEINQSKT LLPNITLGYA IYDDCSISAI ASEAALALVN
GGQELIEYPD CKGSSNVAAI IGCDSSTSSI AAARTVGTFG IPMISYFATC SCLSDKQEYP
TFFRTIPSDK YQSKLLAELV KTFGWNWIGT VRSNTDYGNF GMRTFIEEAQ KIGVCIAYSE
SFYRTDPAEK ISKIVQVMKE ATTKVVVGFL QKRDMRVLIE EILRQNVTGI QWIGTEGWLT
GDTLFTEERA RARVGAIGPT TRRTEIVGLR DHLLKIHPTR FPDSTFVKEF WENLFSCSLT
TGDTTDTRSS AFQVRPCTGN EHLDGLENTY LPAIMDGSSY HVYKAVYAVA HALDDMLSCE
ENNGPFMNST CAQISSFEPW QLLHYLHSVN FTASTGELVY FDENGDPVPK YDLINLQMNA
EDSSDCIKCP LEYWSNQQKD RCVPKMIEFL SFQEVLGYVL VALASVGACL ALATVAFHPV
ICSLRESNDF VFDIRIYGFC TYAGITWNDL QASSKRLLAK FA
//
