ID A0A401SR59_CHIPU Unreviewed; 543 AA.
AC A0A401SR59;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Wntless-like transmembrane domain-containing protein {ECO:0000259|Pfam:PF06664};
GN ORFNames=chiPu_0011316 {ECO:0000313|EMBL:GCC32852.1};
OS Chiloscyllium punctatum (Brownbanded bambooshark) (Hemiscyllium punctatum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Galeomorphii; Galeoidea; Orectolobiformes; Hemiscylliidae;
OC Chiloscyllium.
OX NCBI_TaxID=137246 {ECO:0000313|EMBL:GCC32852.1, ECO:0000313|Proteomes:UP000287033};
RN [1] {ECO:0000313|EMBL:GCC32852.1, ECO:0000313|Proteomes:UP000287033}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=30297745; DOI=.1038/s41559-018-0673-5;
RA Hara Y, Yamaguchi K, Onimaru K, Kadota M, Koyanagi M, Keeley SD, Tatsumi K,
RA Tanaka K, Motone F, Kageyama Y, Nozu R, Adachi N, Nishimura O, Nakagawa R,
RA Tanegashima C, Kiyatake I, Matsumoto R, Murakumo K, Nishida K, Terakita A,
RA Kuratani S, Sato K, Hyodo S Kuraku.S.;
RT "Shark genomes provide insights into elasmobranch evolution and the origin
RT of vertebrates.";
RL Nat. Ecol. Evol. 2:1761-1771(2018).
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004439}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004439}. Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004653}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the wntless family.
CC {ECO:0000256|ARBA:ARBA00008148}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GCC32852.1}.
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DR EMBL; BEZZ01000466; GCC32852.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A401SR59; -.
DR STRING; 137246.A0A401SR59; -.
DR OMA; EGQWKWD; -.
DR Proteomes; UP000287033; Unassembled WGS sequence.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017147; F:Wnt-protein binding; IEA:InterPro.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR InterPro; IPR047843; WLS-like_TM.
DR InterPro; IPR009551; Wntless.
DR PANTHER; PTHR13449; INTEGRAL MEMBRANE PROTEIN GPR177; 1.
DR PANTHER; PTHR13449:SF2; PROTEIN WNTLESS HOMOLOG; 1.
DR Pfam; PF06664; MIG-14_Wnt-bd; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000287033};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT TRANSMEM 14..36
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 234..254
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 266..283
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 303..321
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 333..353
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 378..402
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 429..453
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 473..494
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 179..497
FT /note="Wntless-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF06664"
SQ SEQUENCE 543 AA; 62357 MW; 8A38F9F7C8382257 CRC64;
MAGAIIENMS TRKLCIFGGI LLVFQVISFL VGGLIAPSPT SGISYLATKC VDVKKHHQKS
KWFMPWGPNQ CEKKIQKFSE AMQQQIGAND IVFAIHVPHQ SLEMSSWFQF LLVVLQFEIE
FQIGNEISEG AVVTLDVSLG YRDDRFSEWT EMAHSFESRK LNCNFSSPKH HDSQGQLYDC
DLLPFMELGS VAHKYYLINI RLPVNEKKNI NMKIGKHKDL RLVGIHQNGG FTRVWFAMKT
FLTPSILIIM IWYWRRITMM TRPPVLLEKV IFALGISMTF INIPVEWFSI GFDWTWMLLF
GDIRQGIFYA MLLSFWIIFC GEHLMDQNER NRLSVYLKQI VPIGFGSFCL FIFDLCERGV
QLTNPFYSIW ATDVGTELAM AFIIVAGICA CLYFFFLCFM VFQVFRNISG KRCSLPAMSK
ARRLHYEGLI FRFKFLMLVT LTCAAMTIVF FIISQVNEGH WKWGEYIVQV NSAFFTGIYG
MWNLYVFAIM FLYAPSHKCY SDADQSNGDL GVSGGEELQL TTTITHADGP TEIYRLAGKE
AQE
//
