ID A0A401STD6_CHIPU Unreviewed; 182 AA.
AC A0A401STD6;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE RecName: Full=Natural cytotoxicity triggering receptor 3 {ECO:0000256|ARBA:ARBA00019135};
DE AltName: Full=Natural killer cell p30-related protein {ECO:0000256|ARBA:ARBA00032296};
GN ORFNames=chiPu_0012135 {ECO:0000313|EMBL:GCC33665.1};
OS Chiloscyllium punctatum (Brownbanded bambooshark) (Hemiscyllium punctatum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Galeomorphii; Galeoidea; Orectolobiformes; Hemiscylliidae;
OC Chiloscyllium.
OX NCBI_TaxID=137246 {ECO:0000313|EMBL:GCC33665.1, ECO:0000313|Proteomes:UP000287033};
RN [1] {ECO:0000313|EMBL:GCC33665.1, ECO:0000313|Proteomes:UP000287033}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=30297745; DOI=.1038/s41559-018-0673-5;
RA Hara Y, Yamaguchi K, Onimaru K, Kadota M, Koyanagi M, Keeley SD, Tatsumi K,
RA Tanaka K, Motone F, Kageyama Y, Nozu R, Adachi N, Nishimura O, Nakagawa R,
RA Tanegashima C, Kiyatake I, Matsumoto R, Murakumo K, Nishida K, Terakita A,
RA Kuratani S, Sato K, Hyodo S Kuraku.S.;
RT "Shark genomes provide insights into elasmobranch evolution and the origin
RT of vertebrates.";
RL Nat. Ecol. Evol. 2:1761-1771(2018).
CC -!- SUBUNIT: Homodimer in the unliganted form. Interacts with CD3Z.
CC Interacts with and is activated by binding to NCR3LG1. Interacts with
CC and is activated by binding to BAG6. {ECO:0000256|ARBA:ARBA00011456}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the natural cytotoxicity receptor (NCR) family.
CC {ECO:0000256|ARBA:ARBA00006531}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GCC33665.1}.
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DR EMBL; BEZZ01000537; GCC33665.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A401STD6; -.
DR STRING; 137246.A0A401STD6; -.
DR OMA; NITVFQF; -.
DR Proteomes; UP000287033; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0002429; P:immune response-activating cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0045954; P:positive regulation of natural killer cell mediated cytotoxicity; IEA:InterPro.
DR CDD; cd00099; IgV; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR043226; NCR3.
DR PANTHER; PTHR47904; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 3; 1.
DR PANTHER; PTHR47904:SF1; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 3; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000287033};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..41
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 42..182
FT /note="Natural cytotoxicity triggering receptor 3"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018996045"
FT DOMAIN 36..135
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 182 AA; 20628 MW; F09B930D5BB5BF26 CRC64;
MCFSRLLASL ICNLLTNSES MVFRQLLVLM LSISFPRSAV GTKMNITVFQ FPPFITVTEG
ESVTLNCALD FEGTSSPVGA VYWTRGKSDE YKLDDSPFYT ARLQKSGSDS FAKKRIFINI
SDLIEKDSDT YYCNIKFFGA GKRHGNGTKL EVKRKWQLRI IIYIFKKRSS GAHISSEMLK
TE
//