ID A0A401STJ9_CHIPU Unreviewed; 2305 AA.
AC A0A401STJ9;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=T-box domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=chiPu_0012166 {ECO:0000313|EMBL:GCC33696.1};
OS Chiloscyllium punctatum (Brownbanded bambooshark) (Hemiscyllium punctatum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Galeomorphii; Galeoidea; Orectolobiformes; Hemiscylliidae;
OC Chiloscyllium.
OX NCBI_TaxID=137246 {ECO:0000313|EMBL:GCC33696.1, ECO:0000313|Proteomes:UP000287033};
RN [1] {ECO:0000313|EMBL:GCC33696.1, ECO:0000313|Proteomes:UP000287033}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=30297745; DOI=.1038/s41559-018-0673-5;
RA Hara Y, Yamaguchi K, Onimaru K, Kadota M, Koyanagi M, Keeley SD, Tatsumi K,
RA Tanaka K, Motone F, Kageyama Y, Nozu R, Adachi N, Nishimura O, Nakagawa R,
RA Tanegashima C, Kiyatake I, Matsumoto R, Murakumo K, Nishida K, Terakita A,
RA Kuratani S, Sato K, Hyodo S Kuraku.S.;
RT "Shark genomes provide insights into elasmobranch evolution and the origin
RT of vertebrates.";
RL Nat. Ecol. Evol. 2:1761-1771(2018).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00201}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00201}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GCC33696.1}.
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DR EMBL; BEZZ01000538; GCC33696.1; -; Genomic_DNA.
DR STRING; 137246.A0A401STJ9; -.
DR OMA; MMENRFK; -.
DR Proteomes; UP000287033; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd19682; bHLHzip_MGA_like; 1.
DR CDD; cd20195; T-box_MGA-like; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 3.
DR Gene3D; 2.60.40.820; Transcription factor, T-box; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR046360; T-box_DNA-bd.
DR InterPro; IPR036960; T-box_sf.
DR InterPro; IPR001699; TF_T-box.
DR InterPro; IPR018186; TF_T-box_CS.
DR PANTHER; PTHR11267:SF32; MAX GENE-ASSOCIATED PROTEIN; 1.
DR PANTHER; PTHR11267; T-BOX PROTEIN-RELATED; 1.
DR Pfam; PF00010; HLH; 2.
DR Pfam; PF00907; T-box; 1.
DR PRINTS; PR00937; TBOX.
DR SMART; SM00353; HLH; 3.
DR SMART; SM00425; TBOX; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 3.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS50888; BHLH; 3.
DR PROSITE; PS01264; TBOX_2; 1.
DR PROSITE; PS50252; TBOX_3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00201};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00201}; Reference proteome {ECO:0000313|Proteomes:UP000287033};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 38..219
FT /note="T-box"
FT /evidence="ECO:0000259|PROSITE:PS50252"
FT DOMAIN 1315..1365
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 1554..1603
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 1851..1900
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT REGION 535..563
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 785..808
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1600..1627
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 545..563
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 789..808
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2305 AA; 256832 MW; A9E79310268741EF CRC64;
MERAAPPAIN PSHAHRLEGN MMKSPPFCLK SGNVKVSLKK WSVWDKFYNL GTEMRMSKRG
RFMFPYCEYS VSGLDPDKNY IMAMDISPVD NYRYRYNGCK WQINGKATPH VTGRLYFHPN
GSVSGKEWMV KPVSFAKMRL TNCPTAEEGN AILHSMHRYV PQLHIIVADG IIEKLNLNDP
RVYTFVFQQT EFFAVTKYEN KFIRQLKHFY NPYGTALRDV KTSKQDVGNS QRPRKRCEKK
TLYPAENMHS TVSDQEPKEE LKTIIPIKDG AVRIQESMNN RGVTKEMRKI VSVENVLQME
GSFNLKGSLG DPVEIGKLEQ KLRNDLRWNG KHEILHPALR EFGIKLSDLQ LTECINVERL
GLASTQNVEL VSSFPVNESH GIRETGIPFI SRTGKTNDLT KIKGWKNKFN LQPGSPENNP
SPSPSSVSPA VIKNRSAFVS DLLDEYLEKE GKIIEQSLLY DYKIPEIGCQ TPTTLDPSCN
IQQNATRSSD FGAPLKNKSS HLEMSPVLEK HFSVTNKGIF IRDIQSTSVD AKAKCTKQKN
DNSAAKRPKI ASQYDNKTQL SSNNKESAIC ATTPQKKQLK SGSTYLKVVP VASSPNGGKK
SNISTNQTET IYISDDKNAE KSEPRNLRIE STSQATIDPS SVMEHPSTTT TNRSTASKVV
EVISYCNWNE SRVKIIKLIA ECAMANKLPL IQRLDNYEIN LEKSDGTLFP PKKRIDVRAT
IQNVSDSEHG CIRPLVQNMV IEAVVGNSAF KTKLNNLISK VSKDSSKQTK VEQLDSSVHV
VMDLEKSVSS PEKSPSETSC TTNPSNRLTA EGKAQSFPVI TAQKREQGVS IAATDTTVKK
VSKAPSPIRS AVTTFQRIGA LSTILTNSTT TPTPNCFMNS VASENKPETS AAPPTRYLLC
KTNSSGLSSG SPASLDQDGR RQCIAVPNTL KLQPGDNLML QPIKAADGRQ LYRHSSGKIF
QLVYTKTPEQ TPVQQLNIPQ SPIPGTNSVV KIVTSTVTTL EGDANTSLCN TTATNSELCT
KTSLSEASVG RLHNSTSLCD MTATKLQLQC VPATWTLVDQ LSPSQSLRMF SETTTQAEQH
DNIIPLADCQ TKANLVNLNN DIFDLEMNPV KSSEQGECNQ RTKTVNTFPM KSETITVTGA
YETKWVTEDS TFGEDCKRTD SMEKFNTQLN ASKRSEAHIK VERHLAEING DERMDSDGPE
ICTVTIKEEP LNDEEHNSFT AWREESFRSS KFWNRSFNLN TEAVTEAELG VQTHSSNRNR
DGVGNLVSSS RIPRNLLIVN NPAVPHRGFF QNSQSFSNST KRRVYETSVL CEARKKAILH
NLRERESRRM MENRFKVLKN KLFDDKQIAS KGAILDEAID VINNLDRQSK NLTVEKELLL
GKQKILLEKI SLLSGMEPVV TQDGIEAGEI IETGETLSFS SGRVSSSQNS FGIKWFAEDG
PVNTLDEHGT NCGLNLKYEV NSTGSDDIVA VKIGDYFNEK CNSELDYSGS TNTFAVKREE
NLSQEDCSTV SSVNEEYSGS SRFCSLSDFS TDMEALNKMG MQCSEPSRGW IANRKATSHT
LRERESRKLM ENRFKLLEST VFNDKKAPKG AILTKAIDVI SDLDMQSEEL FKEKELLKKK
QKKLLEEISL LADTRSDAVE DQAEDGHFFS VKKTSGARGL TFQKPSEPQW LESSSPSDTA
VTKGNMVSAL SESHDTDCTG GADWEQDELK ANCLFPPKIA GDLKEKHYQE SLNPDGYDST
ALRRKIFNGK DEDALFTIGR ESSIGSSDFG SHSDFDVNAD DVNEIDVEIL SHSDAEYFDV
EMEDGEVADG TSTAEKLCAP PRWHFHNYSQ SHKFSPKRKI YNMSELKKSR KNPLLHTLRE
REWRKLMQNR FSELRELLFE DERVSKRAIL DEAISEIQNL CQQGHKLYLE KKLLMKKHKA
LLKIIAVLSG EKKVKTQKSD AAVCGKHSEN YDHNRTPVSP GPSLMSTAKG NNEESTLVPI
AGTPFRLLLE KIAVSPHGEE YGEWDTRSQT EAHGTKELPP RSLVIHQQDD AHLAFLEGYS
QMTSSTQPRE ETQMQKLPER LEKISDTAST AIDVASRNLK ILQDEKQYAN SMGLNFKSAK
DLPSNGDVKK SSEGALYWSK SVDKDSSAES FEKNPIDAKS AVKGKLQVIR SAKGQDILQK
LAKKVQEAGI KPWTWKSKRE DSENVSQNLF DNESKLMQCF QKASTSANES SIAQYVCTET
SDLLVKDKSL HNLLPGQTLK HPASLNRGGA DQLEAELDLD SVSSDGSTTA TCAVREPKIF
ISSVDIHSAN EANANGGYLL LDSTQ
//
