ID A0A401STZ1_CHIPU Unreviewed; 1281 AA.
AC A0A401STZ1;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=Ras GTPase-activating-like protein IQGAP1 {ECO:0008006|Google:ProtNLM};
GN ORFNames=chiPu_0012304 {ECO:0000313|EMBL:GCC33833.1};
OS Chiloscyllium punctatum (Brownbanded bambooshark) (Hemiscyllium punctatum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Galeomorphii; Galeoidea; Orectolobiformes; Hemiscylliidae;
OC Chiloscyllium.
OX NCBI_TaxID=137246 {ECO:0000313|EMBL:GCC33833.1, ECO:0000313|Proteomes:UP000287033};
RN [1] {ECO:0000313|EMBL:GCC33833.1, ECO:0000313|Proteomes:UP000287033}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=30297745; DOI=.1038/s41559-018-0673-5;
RA Hara Y, Yamaguchi K, Onimaru K, Kadota M, Koyanagi M, Keeley SD, Tatsumi K,
RA Tanaka K, Motone F, Kageyama Y, Nozu R, Adachi N, Nishimura O, Nakagawa R,
RA Tanegashima C, Kiyatake I, Matsumoto R, Murakumo K, Nishida K, Terakita A,
RA Kuratani S, Sato K, Hyodo S Kuraku.S.;
RT "Shark genomes provide insights into elasmobranch evolution and the origin
RT of vertebrates.";
RL Nat. Ecol. Evol. 2:1761-1771(2018).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GCC33833.1}.
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DR EMBL; BEZZ01000547; GCC33833.1; -; Genomic_DNA.
DR STRING; 137246.A0A401STZ1; -.
DR OMA; KGVLVHW; -.
DR Proteomes; UP000287033; Unassembled WGS sequence.
DR GO; GO:0120025; C:plasma membrane bounded cell projection; IEA:UniProt.
DR CDD; cd00201; WW; 1.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 4.10.270.10; Myosin, subunit A; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001202; WW_dom.
DR PANTHER; PTHR14149; RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF; 1.
DR PANTHER; PTHR14149:SF15; RAS GTPASE-ACTIVATING-LIKE PROTEIN IQGAP1; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00612; IQ; 3.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00033; CH; 1.
DR SMART; SM00015; IQ; 3.
DR SMART; SM00323; RasGAP; 1.
DR SMART; SM00456; WW; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS50096; IQ; 3.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000287033}.
FT DOMAIN 44..159
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 688..715
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 914..1148
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT COILED 168..195
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1281 AA; 145279 MW; C86D075884583943 CRC64;
MSTSDDVDGL GAVRPHYGSV LDNERLTAEE MDERRRQNIA YEYLCHLEEA KRWMEACLDE
ELPPTTELEE GLRNGVYLAK LGNFFSPKVV SLKKIYDCEQ TRYKATGLHF RHTDNTIQWF
NAMSNIGLPK IFYPETTDIY DRKNMPRCIY CIHALSLYLF KLGLAPQIQD LYGKVAFTEE
EINNMKTELE KYGIQMPAFS KIGGILANEL SVDEAALHAA VIAINDAIEK GIPAETLATM
QNPNAMLVNL DSTQSVQYQN TLSAAKHEKV ANARNKDVPG SPQEERDVYE ELLTQAEIQG
NVNKVNLQNG LKNVDGALEQ QDGTALYNAL KSPALGLRDV ELDNRDWYLK QLSSDKQLKA
QEQGSKDPLT KEELQVGVDQ ANQDGRRFRK MLEAVSRINA AIRKGVAEDT VTELMNRDAQ
LPEVLPFAAE LYQQELSTLQ QQSHQGNLTH AELAVAVEML SSVALINRAL EAGDVNGVWR
QIQNPVTGLT NVDDGNAQRY VDELMRMKAR ARAESNEFLT WNDIQGSVDQ VNIVVQEEHD
RIKAIGLINE AVDEGDPQKT LNALLLPSAK LADVLPPVAE HYQETLIRAK REKAQETQDD
SAVLWLDEIQ DTIWKSNKDT QDAEKFSLGI LAINEAVDHG DTAQILSALR SPDVGLYGVT
SECDDTYRQE LTEAKQAKKA EGDNGSQWVR HWVKGGYHYY YNLVTKQGSW EQPSGFVQNN
TQLSKEEIQS TISGVTAAYN REQLWVANES LITKLQARCR GYLVRREYSD RMNFLKKQQP
AILAIQSNWK GYKQRQAYKN RLQYLKDNTA STVKIQSLVR MQQARKKYQD RLKYFKDHEV
VSHSKKLTRK NKEQLSDMMQ INKQKGGLKA LSKEKRMKLE AYQNLFYLLQ TNPTYLAKLI
FQMPQNKSTK FMDSVIFTLY NYASNQREEY LLLKLFKTAL QEEIKSKVDQ LHEIITGNPT
VIKMVVSFNR GARGQNALRQ ILAPVVKEII EERSMNIKTD PVDIYKAWVN QMESQTGEAS
KLPYDVTPDQ ALSHDEVRQR LDTSIKNMRT ITEKFLSAIV TSVDKIPYGM RLIAKVLKDS
LHEKFPDATD DELIKIVGNL LYYRYMNPAI VAPDAFDIID ISAGGGGLTT DQRRNLGSIA
KVLQHAASSK MFDKENCHLG SVNDYLSQAH MKFRRFFQAA CEVPELEDRF NVDEYSDRVT
VTKPVIYISI GEIINTHTLF LDHQDAIAPE HNDPIHELLE DLGEVPTIES LVGKYLLFYS
APLPPCQLHP DSTEESGHVP L
//
