ID A0A401T067_CHIPU Unreviewed; 938 AA.
AC A0A401T067;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=chiPu_0014502 {ECO:0000313|EMBL:GCC36011.1};
OS Chiloscyllium punctatum (Brownbanded bambooshark) (Hemiscyllium punctatum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Galeomorphii; Galeoidea; Orectolobiformes; Hemiscylliidae;
OC Chiloscyllium.
OX NCBI_TaxID=137246 {ECO:0000313|EMBL:GCC36011.1, ECO:0000313|Proteomes:UP000287033};
RN [1] {ECO:0000313|EMBL:GCC36011.1, ECO:0000313|Proteomes:UP000287033}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=30297745; DOI=.1038/s41559-018-0673-5;
RA Hara Y, Yamaguchi K, Onimaru K, Kadota M, Koyanagi M, Keeley SD, Tatsumi K,
RA Tanaka K, Motone F, Kageyama Y, Nozu R, Adachi N, Nishimura O, Nakagawa R,
RA Tanegashima C, Kiyatake I, Matsumoto R, Murakumo K, Nishida K, Terakita A,
RA Kuratani S, Sato K, Hyodo S Kuraku.S.;
RT "Shark genomes provide insights into elasmobranch evolution and the origin
RT of vertebrates.";
RL Nat. Ecol. Evol. 2:1761-1771(2018).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SUBCELLULAR LOCATION: Cytoplasm, P-body
CC {ECO:0000256|ARBA:ARBA00004201}.
CC -!- SIMILARITY: Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.
CC {ECO:0000256|ARBA:ARBA00005601}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GCC36011.1}.
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DR EMBL; BEZZ01000773; GCC36011.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A401T067; -.
DR STRING; 137246.A0A401T067; -.
DR OMA; NDWDQDQ; -.
DR Proteomes; UP000287033; Unassembled WGS sequence.
DR GO; GO:0000932; C:P-body; IEA:UniProtKB-SubCell.
DR GO; GO:0032574; F:5'-3' RNA helicase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IEA:UniProtKB-KW.
DR CDD; cd18038; DEXXQc_Helz-like; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR049080; MOV-10-like_beta-barrel.
DR InterPro; IPR026122; MOV-10/SDE3_DEXXQ/H-box.
DR InterPro; IPR049079; Mov-10_helical.
DR InterPro; IPR049077; MOV-10_Ig-like.
DR InterPro; IPR049075; MOV-10_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR PANTHER; PTHR10887:SF537; HELICASE MOV-10; 1.
DR Pfam; PF13086; AAA_11; 2.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF21634; MOV-10_beta-barrel; 1.
DR Pfam; PF21635; Mov-10_helical; 1.
DR Pfam; PF21633; MOV-10_Ig-like; 1.
DR Pfam; PF21632; MOV-10_N; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000287033}.
FT DOMAIN 2..67
FT /note="Helicase MOV-10 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF21632"
FT DOMAIN 121..241
FT /note="Helicase MOV-10 Ig-like"
FT /evidence="ECO:0000259|Pfam:PF21633"
FT DOMAIN 292..358
FT /note="Helicase MOV-10 helical"
FT /evidence="ECO:0000259|Pfam:PF21635"
FT DOMAIN 360..446
FT /note="Helicase MOV-10-like beta-barrel"
FT /evidence="ECO:0000259|Pfam:PF21634"
FT DOMAIN 500..582
FT /note="DNA2/NAM7 helicase helicase"
FT /evidence="ECO:0000259|Pfam:PF13086"
FT DOMAIN 601..693
FT /note="DNA2/NAM7 helicase helicase"
FT /evidence="ECO:0000259|Pfam:PF13086"
FT DOMAIN 706..927
FT /note="DNA2/NAM7 helicase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13087"
SQ SEQUENCE 938 AA; 106582 MW; A91A45A16A89F239 CRC64;
MREVGLKFIE FLKDAEQEEV TDREILKSIY NSQFRGRNGV LSVNFSSVLY ALSRTGKARV
TGGKIYFNSQ LKKVEYADQY RNRWPDPADN LGTPSPAAPI QEPGKKDRAK AIIYQMRLNK
KQIVQNKSGV RVFSDFDTSE GKIEVSLHPN NQQSVPIYIK NEGIEIVTFV RCEMLCKFPV
FTLGDEANVT SSQQITLATG ITHQIEVICS MPDSGYFPVT LTFQFEDASS KPFSIIRFFS
ARVTSSIIEE LKPTGPYKPY QGSNRRPTEA IIEDGLMPDV FSNYRLEKAR TLHQFHYPEA
LFTALKHGLK LDKDLPDVKM EVERINSLLG TLLGFGSYSE RFSLLLHMEE IQMEADITRY
NMKGVPMHRD PHRRHLLILQ VPGVAENRPS VLRGDHLFAS KCDDVKQPIT RYKGYVHAVE
LEQVKLGFSQ KLVNAFINNM KFDVTFTFNR LPLQLQHRAA KLANKDTSLK EVLFPTYSDG
QCMHPLDKSL AFYDRSLENN PEQADAVRYI VSGISRPAPY LVFGPPGTGK TVTIVEAIKQ
VLCCIPTAHI LACAPTNSAT DLLCQRIQKH VNKRYIYRLN AVSRIWSAIP RDVQECSNWN
ESNQAFEFPT KEELQQYRVI ATTLITAGRL ASAKFPYGYF SHVFIDEAGN AIEPECVIAV
AGLLDVMDLE KNKDGGQLVL AGDPKQLGPV LRSPIAIKHG LDLSFLERLM SGNTLYQKNP
STGCYDKHFV TKLLRNYRSH PSILRIPNEL FYDNELKAHA DTLISHSYCQ WQELPKKDFP
IIFHGVLGKD EREEKSPSFF NSEEIQQVLI YLKKLLTNQG KKGFAKISPK EIGVITPYRK
QVEKIREAIY RLDVELKAMN DIRELKVGSV EEFQGQERKV IIISTVRSCS NYLQMDEDFN
LGFLKNPKRC NVALTRAKAL LIVVGNPKIL SKDPNWNR
//
