ID A0A401T6U0_CHIPU Unreviewed; 2250 AA.
AC A0A401T6U0;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=Calponin-homology (CH) domain-containing protein {ECO:0000259|PROSITE:PS50021};
GN ORFNames=chiPu_0016882 {ECO:0000313|EMBL:GCC38368.1};
OS Chiloscyllium punctatum (Brownbanded bambooshark) (Hemiscyllium punctatum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Galeomorphii; Galeoidea; Orectolobiformes; Hemiscylliidae;
OC Chiloscyllium.
OX NCBI_TaxID=137246 {ECO:0000313|EMBL:GCC38368.1, ECO:0000313|Proteomes:UP000287033};
RN [1] {ECO:0000313|EMBL:GCC38368.1, ECO:0000313|Proteomes:UP000287033}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=30297745; DOI=.1038/s41559-018-0673-5;
RA Hara Y, Yamaguchi K, Onimaru K, Kadota M, Koyanagi M, Keeley SD, Tatsumi K,
RA Tanaka K, Motone F, Kageyama Y, Nozu R, Adachi N, Nishimura O, Nakagawa R,
RA Tanegashima C, Kiyatake I, Matsumoto R, Murakumo K, Nishida K, Terakita A,
RA Kuratani S, Sato K, Hyodo S Kuraku.S.;
RT "Shark genomes provide insights into elasmobranch evolution and the origin
RT of vertebrates.";
RL Nat. Ecol. Evol. 2:1761-1771(2018).
CC -!- SUBCELLULAR LOCATION: Nucleus outer membrane
CC {ECO:0000256|ARBA:ARBA00004605}; Single-pass type IV membrane protein
CC {ECO:0000256|ARBA:ARBA00004605}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004605}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GCC38368.1}.
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DR EMBL; BEZZ01001167; GCC38368.1; -; Genomic_DNA.
DR STRING; 137246.A0A401T6U0; -.
DR Proteomes; UP000287033; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR039906; Anc-1/SYNE1/2-like.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR PANTHER; PTHR21524:SF5; KLARSICHT PROTEIN; 1.
DR PANTHER; PTHR21524; SPECTRIN REPEAT CONTAINING NUCLEAR ENVELOPE PROTEIN 2; 1.
DR Pfam; PF00307; CH; 2.
DR SMART; SM00033; CH; 2.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000287033};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 31..137
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 180..284
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REGION 147..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 361..422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 486..515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 831..872
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1005..1044
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1113..1176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1238..1264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2016..2035
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2054..2078
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1589..1626
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 369..400
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 401..422
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 501..515
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 832..869
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1134..1151
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1155..1176
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2055..2078
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2250 AA; 249118 MW; 1B28D52DBF500C75 CRC64;
MLSAGPAPTS QQEERADIDN VKCVLQAEHE KVQNRTFTNW VNAQLAKHKP PSVIQDLFQD
LRDGHRLLDL LEVLSGQQLA HDRAHSNPIH WMSNVTTALN FLRSKSIKLV NINVLDIVDG
NPTVILGLIW SIILYFQVEK LASGLTSRQT PMEPSPALNS SPAALSPQRE ETRIHAGQKK
SAETTLLQWV QEKTEDLGFV IRDFSTSWRS GLAFVAIINA LRPGLVDLAE LKQRSDTENL
EMVFKVAEQE LKIPRLLEAQ DIAVSNPDEK SIITYISQFL QYSKEHAAAE DTKKQTESPC
LMSFSKGSSL TRAQQHLAAM RELCDGNVDA EIKATLQSCE DRKTDLEQRL IKCFSWFQDP
VSSPQTGELK SERQREVDLT EAATRKAPSG RAKRQTEQAD DPGGENSAQP VTKVGQASTQ
LGAAEPNRNI LVDIGASEIP GPWTEWIRID DLGREGQTQS VQETQRRKLQ GDWLQRGDCQ
QSVTHCLTDG EPPATVKGEH SGQHYSMSQR GDTEAPGLNF TQLQMQSSSG EDQGPAQAMG
SHTDLVAISS RSQGLADDSG QLAKYLLMGK CEMEMFPNVD ITHLEEDSLS GQGQGETTDR
GGSALLASAF PSKKHQGCLQ TRDCLAQSQK EKTGQKALDT ARTEKPAQVT FMALSKEEQA
AHRGTKAIAE FSKGFLTEQL SLTGRDQGED IPVCVEVSLS EEEQLDKPTV QATVEWPGAV
QDQSDVSDTL FGRKQGESLT LCDKESLIGA DQTDPCTMKS SVNLNGAIQT GQEQTGEYHI
EGNQTLMREL PSHDNPEFVF DQEQTISATT ERTVQLPKEN SSGIDQAYGL LEDGSQKSTT
VSVSERELTG NQSRRGPTQL STSSPIRTGR CDHPTMAGSG QLSELALSGD IKVCDLPEDD
SGQLLPDSVS EEGTDADLTA EDSAQSGREC LMEKELNLLE SEEISQLGTE LHSGKVQTLG
PLGVGSPECL WEGEHGNRTT TGSSAPLMTM TPSGQLQGDA TVMEDSAGVS GKDLSERDKA
DGLVSDVSPG AVSEPLSGEK QTENAVAQNT VGLVRSSEGQ SAEIRENMTG RKWGDDLTLS
VEEILIRADQ TDPCKMKDSV KWEGAIQGEQ ELTGGCCGKV STPSKIGGTT DQDEEYGLPR
DDTDRLPISE QSEDDTPPAE MSVTGATQTM TQNNVDSLDW ERMKLWAHEP TGDPGNPEHA
LPEPEGWTER QQAVALLREN SEPAQQSCFV QCTQDAVSEQ EEAGRAGSRR HQPAELNPPG
VQPLGAECQR SVQAIIPTGE MISPEVDVSL EPGLSGHFEG EPLSQVEQVK EASAESAPVF
QIRADQTATP EGDAFPPRIH IPQNSKEMEN SAQSVSCSSN AERQLSAGSA ARLVRTLNED
LEPQDEGELT EKESTMTLTW PLADFSQSQM EYFECSNLTD DPVRKDSGKP VHSTEQEFAD
VMTLGLVDPS ERAQQGKETR DEEDRRLADV ERQDHNVKTG NEISERETSL RMAFTALESM
KEQILSLHSS LVQFQNKPKV LTGFSFKLEP EVQMLKNLQT QVKSQIESCE DLQSRLSKAS
SMLEPEDQCA VSAVAVGHTQ RCREIGSQAQ LAEEALQALA QLLQLLQAAE QEGASQDDKL
RLVEEEEGEE KTRLLQDRAL ELDKTLAAAK ICLVDKNSGE RTRCWDLASS LGCRSEAARL
GLGRQHRATQ EELHQAFCTR QNCLIKDLQE IGKRAEELRL REATCPGVQW RLRCLNDLNT
ELQSKASELK ELRYLMEQLT VANPALRGEA QEHLYIAQCV LEETERNIHD RQDQCHMIVA
FLRQYQNYKK ELTATIQKGA AVLPGHTSYM GKEKLQRLMN DINDVKLEFN SQQGKVDELR
KVCRHLQSEL KKVMDCNSLP FQTEAEELLD QWLDDEIPSQ AKEIPSFQEK VVRIQELLGW
KEIPLELQVV STVKKKIEQV KHINKQLNTM DKAPTGHLSH SVVKHEPTGV PSESDGREQV
LPLCLNREGV RPVFEFSVEG QQCSQHRLGA HEEMVWSGED PSDDDITPTA EDLPETPCAQ
TDRVQEQGND SHYLGETEQC RRQHQASEEE TQAKRRRELW PVQVEQDQNM QPASKTPLQQ
QDTELEALEK YPEKLKEHVT RYRQLTEHLA SLETSLTAST AQIPTSYKAA IEQAERQTAL
GREIDCIELK VLELKDKAHD LEGTADISNE GSASQAVSTL SGRWLRLRDS AREQELRCSG
LREEWKSINE EVPMANDQWE QYHLLHNLGH
//
