ID A0A401T6X6_CHIPU Unreviewed; 1098 AA.
AC A0A401T6X6;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=Guanine nucleotide exchange factor DBS {ECO:0008006|Google:ProtNLM};
GN ORFNames=chiPu_0016868 {ECO:0000313|EMBL:GCC38354.1};
OS Chiloscyllium punctatum (Brownbanded bambooshark) (Hemiscyllium punctatum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Galeomorphii; Galeoidea; Orectolobiformes; Hemiscylliidae;
OC Chiloscyllium.
OX NCBI_TaxID=137246 {ECO:0000313|EMBL:GCC38354.1, ECO:0000313|Proteomes:UP000287033};
RN [1] {ECO:0000313|EMBL:GCC38354.1, ECO:0000313|Proteomes:UP000287033}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=30297745; DOI=.1038/s41559-018-0673-5;
RA Hara Y, Yamaguchi K, Onimaru K, Kadota M, Koyanagi M, Keeley SD, Tatsumi K,
RA Tanaka K, Motone F, Kageyama Y, Nozu R, Adachi N, Nishimura O, Nakagawa R,
RA Tanegashima C, Kiyatake I, Matsumoto R, Murakumo K, Nishida K, Terakita A,
RA Kuratani S, Sato K, Hyodo S Kuraku.S.;
RT "Shark genomes provide insights into elasmobranch evolution and the origin
RT of vertebrates.";
RL Nat. Ecol. Evol. 2:1761-1771(2018).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GCC38354.1}.
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DR EMBL; BEZZ01001164; GCC38354.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A401T6X6; -.
DR STRING; 137246.A0A401T6X6; -.
DR OMA; LQRICTI; -.
DR Proteomes; UP000287033; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd01227; PH_Dbs; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd00170; SEC14; 1.
DR CDD; cd11857; SH3_DBS; 1.
DR CDD; cd00176; SPEC; 1.
DR Gene3D; 1.20.58.60; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR035534; DBS_PH.
DR InterPro; IPR035532; DBS_SH3.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR PANTHER; PTHR22826:SF115; GUANINE NUCLEOTIDE EXCHANGE FACTOR DBS; 1.
DR PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00516; SEC14; 1.
DR SMART; SM00326; SH3; 1.
DR SMART; SM00150; SPEC; 1.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000287033};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..164
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT DOMAIN 579..759
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 771..893
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 995..1056
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 497..519
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 967..994
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1057..1098
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 967..982
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1098 AA; 124572 MW; AC36629D4CD70CBE CRC64;
MQQDSPVYAA DITEQLAKQF AIRSGGRGAD GCPIITFPEY SNFTDIPEEE FQTVIKYLTS
IPSFQDGDIG FILLVDRRQD KWSSVKASLL RITGSFPGNL QLVLVLRPSG IFQRAISDIV
LRFNRDDFKL KVPIIMLNSV TELHSHIDKT QLTQELGGTL EYSHSQWLYH RTGIESFAVM
AKETAQMLQA FGTELAETDL PNDVTTTLGL ITTHTQKRDR MKDDLNQARR HGSTLLSSIQ
EPVDVNPDHK FNTDELDNQT TVERLLAQLN ETEIAFDEFW SKHQLKLKQC LQLRHFEQDF
REVKAVLDIV TERHSTFTEF GNSSCHVGHI VKDLCNFEDK SQEVLEKAEA LAVQGDHLIE
DNHYAVDSIL PKCIELRAVC HNLANGLKTK KELLNQSMEL HKRLEQAMQW CDSGIYLLAS
QSVDKCQSQD GAEAALQEIE KYLDTASGQK LEDLSNITNK YKAILGDDLM ARVLKIFQKQ
EEMEEMFEKR STSLKKLAAK QTRPVQPVAP RPEGIPRSPI SYPSPDIRKG HDPNFSHKAN
VTQINLLKRN KSLSKIEMNE HVEGRKCSTS DNEENLAVLR SHVMNELIET ERAYVEELLC
VLEGYAAEME NPSMIPFIPV VLQKKKDVLF GNMPEIYDFH NRIFLRELEN YIDCPELVGR
CFLDRMEDLQ IYEWYCRNKP RSESLWRQCS DCIFFQECQK KLEHKLGLDS YLLKPVQRIT
KYQLLLKELL KYSKNSDGAE DLQEALAAIL GILKAVNDSM HQVAITGYEG NLNELGKLLM
QGSFNVWIDH KKGHAKVKDL ARFKPMQRHL FLHEKALLFC KRREESGEGY EKAPSYSYKQ
SLHMTTVGIT ENVKGDNKKF EIWYNAREEV YIVQAATHEV KNMWVNEIRK VLTSQLEARR
VSNQQQKLEH IPVAPLAIPV NTSPLRSAQK VKRAEIVSPE NHSISVTSPK RQEKVKGWTK
VSQSLDISEE NNDGWSSADD QLNSSDCEEE TNRKLLPGKY TVTADYGKSG GEELTASTGD
LLQLIREGQD GRWLVRNLNT NKEGWVPATN LQTLIGDSSS SQSISSSESA SASSTLSSSS
SCAEHCTASS TSVVDMKG
//
