ID A0A401UP73_9CLOT Unreviewed; 787 AA.
AC A0A401UP73;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Endonuclease MutS2 {ECO:0000256|HAMAP-Rule:MF_00092};
DE EC=3.1.-.- {ECO:0000256|HAMAP-Rule:MF_00092};
GN Name=mutS2 {ECO:0000256|HAMAP-Rule:MF_00092,
GN ECO:0000313|EMBL:GCD11330.1};
GN ORFNames=Ctaglu_29530 {ECO:0000313|EMBL:GCD11330.1};
OS Clostridium tagluense.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=360422 {ECO:0000313|EMBL:GCD11330.1, ECO:0000313|Proteomes:UP000287872};
RN [1] {ECO:0000313|EMBL:GCD11330.1, ECO:0000313|Proteomes:UP000287872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A121 {ECO:0000313|EMBL:GCD11330.1,
RC ECO:0000313|Proteomes:UP000287872};
RA Murakami T., Segawa T., Shcherbakova V.A., Mori H., Yoshimura Y.;
RT "Genome sequencing and assembly of Clostridium tagluense strain A121.";
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Endonuclease that is involved in the suppression of
CC homologous recombination and may therefore have a key role in the
CC control of bacterial genetic diversity. {ECO:0000256|HAMAP-
CC Rule:MF_00092}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_00092}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family. MutS2
CC subfamily. {ECO:0000256|HAMAP-Rule:MF_00092}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GCD11330.1}.
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DR EMBL; BHYK01000017; GCD11330.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A401UP73; -.
DR OrthoDB; 9808166at2; -.
DR Proteomes; UP000287872; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR GO; GO:0045910; P:negative regulation of DNA recombination; IEA:InterPro.
DR CDD; cd03280; ABC_MutS2; 1.
DR Gene3D; 3.30.1370.110; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00092; MutS2; 1.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR046893; MSSS.
DR InterPro; IPR005747; MutS2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002625; Smr_dom.
DR InterPro; IPR036063; Smr_dom_sf.
DR NCBIfam; TIGR01069; mutS2; 1.
DR PANTHER; PTHR48378; DNA MISMATCH REPAIR PROTEINS MUTS FAMILY DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR48378:SF2; SMR DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF20297; MSSS; 1.
DR Pfam; PF00488; MutS_V; 1.
DR Pfam; PF01713; Smr; 1.
DR PIRSF; PIRSF005814; MutS_YshD; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SMART; SM00463; SMR; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF160443; SMR domain-like; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
DR PROSITE; PS50828; SMR; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00092}; Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00092};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759, ECO:0000256|HAMAP-
KW Rule:MF_00092}; Hydrolase {ECO:0000256|HAMAP-Rule:MF_00092};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|HAMAP-Rule:MF_00092};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00092}; Reference proteome {ECO:0000313|Proteomes:UP000287872}.
FT DOMAIN 712..787
FT /note="Smr"
FT /evidence="ECO:0000259|PROSITE:PS50828"
FT COILED 501..623
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 331..338
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00092"
SQ SEQUENCE 787 AA; 88079 MW; 9EBFE84161A5BB9A CRC64;
MNTKSLKVLE YYKIKDKIKE YTHTTAGKDI IEKLEPYTNM YEVREHLQET NEALLLLSKK
GSAPFEGIYD VRDAISRASK GACLMPTQLL RIAQMLRCAR LFQNYVGSKG GETSRVLEDI
CIGIVPIKKL EDEIFIAIIG DDEISDRASS LLFNLRKSLK EKNSSVKEKV NSLVRSNAKY
LQESLYTIRG DRYVIPVKIE HKSSVPGIVH DQSSSGATLF IEPMSLVNLN NEIKEIMLKE
KAEVERILAE LSYKIYENIN IVDSNANIVW ELDFIFAKAK YAIEINAIIP SVNDEGVIDI
IEARHPLIDP KVVVPSNIYL GRGFTSLVIT GPNTGGKTVT LKTVGLIQLM AMSGILIPAR
DGSVVSFFNE IFADIGDEQS IEQSLSTFSS HMTNIVNIIE KADKKTLALF DELGAGTDPT
EGAALAVSIL ENLRSRGTKV VATTHYSELK GYALKTTGVE NASVEFNVDT LSPTYRLIIG
VPGKSNAFEI SKRLGLPDYI IKNARENISS ETLEFEELVQ SLQEKSIKAE KDARTAEGLK
LEASKLKDKY QEKLYKLENI RENAMYEAQR EAKMLVRNAK EESDVILKNM RELEKLGFPS
EARQMLEEER MKIKDKLESL DKHVQKNNED LGEKLKTVKE GQEVYLPSLD QKVIVISKPD
SRGEVQVQAG IMKINVKVDD LRKSKVTQEE KKKAKINKRE LKLNLRNVST SVDLRGMDAQ
EAVYTVDKYL DDAYLGGLKE VTIIHGKGTG VLRNTITDML KRHGHSKAYR LGNYGEGGSG
VTVVELK
//
