ID A0A402BV28_9FIRM Unreviewed; 360 AA.
AC A0A402BV28;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 03-MAY-2023, entry version 13.
DE SubName: Full=DNA integrity scanning protein DisA {ECO:0000313|EMBL:GCE35144.1};
GN Name=disA {ECO:0000313|EMBL:GCE35144.1};
GN ORFNames=SPFL3102_02979 {ECO:0000313|EMBL:GCE35144.1};
OS Sporomusaceae bacterium.
OC Bacteria; Bacillota; Negativicutes; Selenomonadales; Sporomusaceae.
OX NCBI_TaxID=1917525 {ECO:0000313|EMBL:GCE35144.1, ECO:0000313|Proteomes:UP000287175};
RN [1] {ECO:0000313|EMBL:GCE35144.1, ECO:0000313|Proteomes:UP000287175}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FL31 {ECO:0000313|EMBL:GCE35144.1,
RC ECO:0000313|Proteomes:UP000287175};
RA Aoyagi T., Kurasawa H., Amachi S., Nakajima N., Hori T., Yamamura S.;
RT "Draft genome sequence of Sporomusaceae bacterium strain FL31, a lactate-
RT fermenting bacterium of the class Negativicutes.";
RL Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 ATP = 3',3'-c-di-AMP + 2 diphosphate; Xref=Rhea:RHEA:35655,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:71500; EC=2.7.7.85;
CC Evidence={ECO:0000256|ARBA:ARBA00000877};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GCE35144.1}.
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DR EMBL; BIFV01000012; GCE35144.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A402BV28; -.
DR OrthoDB; 41841at2; -.
DR Proteomes; UP000287175; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0106408; F:diadenylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 1.20.1260.110; DNA integrity scanning linker region; 1.
DR Gene3D; 3.40.1700.10; DNA integrity scanning protein, DisA, N-terminal domain; 1.
DR HAMAP; MF_01438; DisA; 1.
DR InterPro; IPR038331; DisA_sf.
DR InterPro; IPR036888; DNA_integrity_DisA_N_sf.
DR InterPro; IPR018906; DNA_integrity_scan_DisA_link.
DR InterPro; IPR003390; DNA_integrity_scan_DisA_N.
DR InterPro; IPR023763; DNA_integrity_scanning_protein.
DR InterPro; IPR010994; RuvA_2-like.
DR PANTHER; PTHR34185; DIADENYLATE CYCLASE; 1.
DR PANTHER; PTHR34185:SF3; DNA INTEGRITY SCANNING PROTEIN DISA; 1.
DR Pfam; PF02457; DAC; 1.
DR Pfam; PF10635; DisA-linker; 1.
DR SUPFAM; SSF47781; RuvA domain 2-like; 1.
DR SUPFAM; SSF143597; YojJ-like; 1.
DR PROSITE; PS51794; DAC; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000287175};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 11..151
FT /note="DAC"
FT /evidence="ECO:0000259|PROSITE:PS51794"
SQ SEQUENCE 360 AA; 40146 MW; 76B3730F18353AA7 CRC64;
MTILKVERLW DGKFINIIKS LAPGMPLREG LENILRAKMG ALVVVGDSPS IMEIVDGGFL
LNCDYSPSAF YELAKMDGAI ILSHDAKKIL YANAQLVPEA AIATSETGTR HRTAERVARQ
TGALVISISQ RRNLISVYVG NLRYVLKDIT VILNRANQAL QTFEKYQAVL KRGLTHLNAL
EFEDLVTLAD VAGPLIRAEQ VSRIAREIEH NIVELGAEGR LVSMQMEELI SDEDDIFYLI
KDYCLSVDDH THISIREQLS ALPEESLDPY TVCRILGFGV TANSIDIPVV PRGYRLLTHI
PRLPMAVVEN LVARFKTLHH IYNASIAELD DVEGIGEVRA KSIKDGLKRL REQAVLDRQI
//
