ID A0A409V9Z3_9AGAR Unreviewed; 1220 AA.
AC A0A409V9Z3;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE RecName: Full=Ras GEF {ECO:0008006|Google:ProtNLM};
GN ORFNames=CVT24_004368 {ECO:0000313|EMBL:PPQ63616.1};
OS Panaeolus cyanescens.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Galeropsidaceae; Panaeolus.
OX NCBI_TaxID=181874 {ECO:0000313|EMBL:PPQ63616.1, ECO:0000313|Proteomes:UP000284842};
RN [1] {ECO:0000313|EMBL:PPQ63616.1, ECO:0000313|Proteomes:UP000284842}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2629 {ECO:0000313|EMBL:PPQ63616.1,
RC ECO:0000313|Proteomes:UP000284842};
RX PubMed=30283667; DOI=10.1002/evl3.42;
RA Reynolds H.T., Vijayakumar V., Gluck-Thaler E., Korotkin H.B.,
RA Matheny P.B., Slot J.C.;
RT "Horizontal gene cluster transfer increased hallucinogenic mushroom
RT diversity.";
RL Evol. Lett. 2:88-101(2018).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PPQ63616.1}.
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DR EMBL; NHTK01006116; PPQ63616.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A409V9Z3; -.
DR STRING; 181874.A0A409V9Z3; -.
DR InParanoid; A0A409V9Z3; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000284842; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd06224; REM; 1.
DR CDD; cd11883; SH3_Sdc25; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23113:SF354; BUD SITE SELECTION PROTEIN 5; 1.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00617; RasGEF; 2.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000284842};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 98..159
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 793..924
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 985..1192
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 184..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 347..466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 624..653
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 667..741
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 928..957
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1190..1220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..90
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 196..214
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 353..379
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 420..434
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 435..454
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 634..652
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 667..714
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 720..741
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1191..1220
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1220 AA; 134061 MW; 64CF1FBDF0D0FB25 CRC64;
MRSGLAIDTS PGSNAGSSSS KSRFRRRSIS PLSNPAGPRS LPNRGRSISN ASTASTLSIV
SPKSSSTNAS TTSLLIPTAR HSSRSRSPSP ALEETVKLGP DRVLAMHDYS PADETTIYLS
FRAGQIIEVL NRHSSGWWDG KLEGRRGWFP SNYVNDAITS LTQEEPIGMS SSVRLGHRYT
QSSASATSWT TTSSDARSHR SDRTHHRSRS DASEQDVDPS CPPLMTPLLH GLSLLQNVVR
ANRLEHFQPS TACIISCVRS ILASTGTLQR DSEILKDFPR LSDERKRILT SLASLVAKAK
EASEGDPDPA VHAAKVEAMM RLGGQVFAHV RRFLALGVSL GIELGEQDIP PTATPGSAES
QIYMTDDTDS PTKTPTQHRG RNGKGPMPRQ AMRIGGPRSR ERPSDSPGSP TLAKTLARAR
QEQHLLRERT NRHRSGPSVS SLDSLSSIDS QDSIPRSPPP FPHGPSSAVQ VLEALRFTHD
HYLSTIAAFI GHAHSHSRTS HASSTGVLYD LVKEIVEMVC KLLTIVEAVM QHPDISPNRV
GNLRSTKEGL YQVTSSLAES VRLLTLSLPP TMTEEEEKQI LLRSATGALK AGADCVASVK
ICLTRPIGDR PFIVELPNAE NVMSDPFAPP KPSTPQISSA ARLGTRSRSN SYHLNGMEDE
DLTIQAQTPS PVQRHRQVSS SSENSTGSKT SWINSDDTRA TSPDDGQVVT VPVSQPSVEP
DLPSPTSFAH TDDDGTTWEG STRGHLTARA LEEKLIRGDL PTVPLNPIPQ LNQNPDAWMH
GHDYPNEDVA YNTEGHLVGA TMGVLIEKMT PHDSIVDPAF SSVFFLTFRL FSSPTELVEA
IIARYNLTPP ASMPPEYLPV WQHQKGVPVR LRLSNFIKTW LDTYWKPGVD DVAIPALTAF
TKDALVQYFP QPAQRILELL AMWRQSSDST VGPKADRSRD PGMSINPPQA ITPTSGEIPR
PTMTKTLLVA LRKKDFTSIH ITDFDALELS RQLTITECNL YCAIQADEIL SSGQEGATPP
VNVKAVTSLS TVITGWVAES ILNEPDLKKR TNLVKFFVKV ADGLPQKYKT LLEGLRRLAD
HSRNYHEYRS KLRNTAPPAV PFLGLYLTDV TFCREGNPSH RASPADANKK LLNFNKYHKL
ARIVQDMQRF QVPYNLKAIP EVQEYLNDAF EKSKHHGDLQ DLYRRSLLVE PKQTQGDNPP
TSDVRQLFSW ATRSQPQHAS
//
