ID A0A409VCF9_9AGAR Unreviewed; 676 AA.
AC A0A409VCF9;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE RecName: Full=Sorting nexin MVP1 {ECO:0000256|ARBA:ARBA00014268};
GN ORFNames=CVT24_007867 {ECO:0000313|EMBL:PPQ64781.1};
OS Panaeolus cyanescens.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Galeropsidaceae; Panaeolus.
OX NCBI_TaxID=181874 {ECO:0000313|EMBL:PPQ64781.1, ECO:0000313|Proteomes:UP000284842};
RN [1] {ECO:0000313|EMBL:PPQ64781.1, ECO:0000313|Proteomes:UP000284842}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2629 {ECO:0000313|EMBL:PPQ64781.1,
RC ECO:0000313|Proteomes:UP000284842};
RX PubMed=30283667; DOI=10.1002/evl3.42;
RA Reynolds H.T., Vijayakumar V., Gluck-Thaler E., Korotkin H.B.,
RA Matheny P.B., Slot J.C.;
RT "Horizontal gene cluster transfer increased hallucinogenic mushroom
RT diversity.";
RL Evol. Lett. 2:88-101(2018).
CC -!- FUNCTION: Required for vacuolar protein sorting.
CC {ECO:0000256|ARBA:ARBA00002474}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Membrane {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PPQ64781.1}.
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DR EMBL; NHTK01006082; PPQ64781.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A409VCF9; -.
DR STRING; 181874.A0A409VCF9; -.
DR InParanoid; A0A409VCF9; -.
DR OrthoDB; 45524at2759; -.
DR Proteomes; UP000284842; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IEA:InterPro.
DR CDD; cd07597; BAR_SNX8; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR028662; SNX8/Mvp1.
DR InterPro; IPR045734; Snx8_BAR_dom.
DR PANTHER; PTHR47554; SORTING NEXIN MVP1; 1.
DR PANTHER; PTHR47554:SF1; SORTING NEXIN MVP1; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF19566; Snx8_BAR_dom; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50195; PX; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000284842};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 239..346
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 168..194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 676 AA; 75259 MW; 5A153344256BF712 CRC64;
MFNAPRPAQR YVAPTSNGFA SSYVDDNPLA SSVYDDGLDP WSANPSPTPT PIPQAPASVF
SAVIADATVP SIYHRAYNSA DPEGTGDTSV NTLSRVLSTS SLPASTIDRI VNLVSSRPRV
SKLEFFVALA LVALAQAGKD VSIEQVAALS SRNTLPEPTL DLDRFQPTTS TIVPTVRRNS
TLPPPRAPLP AYSDDPWNTN TRFNGLPTNT AFGAPSSGLA NAAPSTLAGT GLPDQWWDKE
ESIKITVLGQ QGFILNRYTV YEVNSNRREH PVVRRYSEFV MLWDVLVRRY PFRLFPSLPP
KRVGADEQFI EQRRRGLARA LNFVVNHPVI KEDGVLATFL SEPSFEAWRK QNAVSLEEES
ASKRVDRTEE MTIPSDLEEK IVVVRGKVVP LIEQWQRICI LAERIIKRRE AAAVRTPPAL
RRAFLPTHFT LPTLSPSSTT ASIAESTVSS APSMTGSLTQ SFLGFVPAPE HPTHPDPQGD
LARLTNTLRA VVEVNEVCWR GDDCELSNGV RQGLEQVAAH TQRHSEIAEL RSRALQDSLL
ESLKAQRDLY LATRDLFIRH DRLSLDQVER LKKRIETNSV KLDGIRAAQK ENWQEEAERL
TAAIEKDQAT IAAQLSRRIF IRACMWHELR VVLHNRENAL LTKAVQGFAR DEHEYAENVA
NNWMSLTEAV ENMPFE
//
