ID A0A409VE83_9AGAR Unreviewed; 1025 AA.
AC A0A409VE83;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=Protein kinase domain-containing protein {ECO:0000259|PROSITE:PS50011};
GN ORFNames=CVT24_005922 {ECO:0000313|EMBL:PPQ63067.1};
OS Panaeolus cyanescens.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Galeropsidaceae; Panaeolus.
OX NCBI_TaxID=181874 {ECO:0000313|EMBL:PPQ63067.1, ECO:0000313|Proteomes:UP000284842};
RN [1] {ECO:0000313|EMBL:PPQ63067.1, ECO:0000313|Proteomes:UP000284842}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2629 {ECO:0000313|EMBL:PPQ63067.1,
RC ECO:0000313|Proteomes:UP000284842};
RX PubMed=30283667; DOI=10.1002/evl3.42;
RA Reynolds H.T., Vijayakumar V., Gluck-Thaler E., Korotkin H.B.,
RA Matheny P.B., Slot J.C.;
RT "Horizontal gene cluster transfer increased hallucinogenic mushroom
RT diversity.";
RL Evol. Lett. 2:88-101(2018).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PPQ63067.1}.
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DR EMBL; NHTK01006132; PPQ63067.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A409VE83; -.
DR STRING; 181874.A0A409VE83; -.
DR InParanoid; A0A409VE83; -.
DR OrthoDB; 49786at2759; -.
DR Proteomes; UP000284842; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0004499; F:N,N-dimethylaniline monooxygenase activity; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR CDD; cd14127; STKc_CK1_fungal; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR020946; Flavin_mOase-like.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR42877; -; 1.
DR PANTHER; PTHR42877:SF5; L-ORNITHINE N(5)-OXYGENASE; 1.
DR Pfam; PF00743; FMO-like; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000284842};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 531..552
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 590..852
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 897..930
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 897..915
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 916..930
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 619
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1025 AA; 116166 MW; 0FD9666DA9C7E59B CRC64;
MPSDTKALNS NSQAKYDGTG PRRPRVVIVG GGLAGIITAI QLKTKLNFHD FTIYDKEEGV
GGTWKVNTYP GCGSDVPGHW YSLSSELNPF WKSYFVGQPE LLAYWENLWR KYSLDKHTQL
NTLVHSAVWS NENQRYTVYL QDVKTGKKSE VEAEITVWAI GGFQAPLYPK DISGMEKFKG
EIFHSARWRD DVTLKGKRVG VIGNGCSAAQ FIPEISKDPS VQLINFCRTP QWFVQRGNYS
YPKWIQWVFA NLPFVMRIYR NWIMARSDMA FLIFRKSNKP LIWVAKKVLG AYIKKKAPKE
EWNNLIPNYA PGCKRIIVDP GYLESLKRPN VSLRWDKIEA IVENGIQLKT GEVVPLDVII
FGTGYSIEPS DLRVRGSRGT SIMEYFESKG GALAYLGSCM PGFPNLFTIL GPNVASGHAS
VIFSEEAQIN HALELMKPVL EGKAKSFEIS DEATDQYNDW LQRRLMNSVW TDCVSYYQAG
RDSKTRIVAT FPGPVALFWW FCRHPKWELF KSSGAEVWQQ ERKRRIIRKR LSLIVTIFAA
LGFGYILSGG SLKMFTKYRE SSGPSRPFPS TTMTSHSHNS STANIVGVHY RVGRKIGEGS
FGVIFEGTNL LNSQTVAIKF EPRKAEAPQL RDECRSYRIL AGCPGIPQIY HFGQEGLHNI
LVIDLLGPSL EDLFDMCGRK FTTKTVCMAA KQMLTRAQTI HEKNLIYRDI KPDNFLIGRP
GTKGSNIIHV VDFGMAKQYR DPKTKQHIPY RERKSLSGTA RYMSINTHLG REQSRRDDLE
ALGHVFMYFL RGSLPWQGLK AATNKQKYEK IGEKKQTTPI KELCEGFPEE FGIYLNYVRK
LGFEETPDYD FLRELFTKVM KSNGDIDDGV YDWNLLNDGR GWEASTGQSQ MVARIQHEQA
HADKRRDERE RRRSQAPQQQ LPNNLTPATP ALQAPVHIPI GSNRANPQHP YATAGIGAGY
EYAQQHEQYK TQQPYGRTSP MVSSVGAAPP AMSNVRATGG VGQDYQQHDE PEPKSFFVRL
LTCRC
//
