ID A0A409VLR0_PSICY Unreviewed; 807 AA.
AC A0A409VLR0;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=VHS domain-containing protein {ECO:0000259|PROSITE:PS50179};
GN ORFNames=CVT25_005747 {ECO:0000313|EMBL:PPQ67146.1};
OS Psilocybe cyanescens.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Strophariaceae; Psilocybe.
OX NCBI_TaxID=93625 {ECO:0000313|EMBL:PPQ67146.1, ECO:0000313|Proteomes:UP000283269};
RN [1] {ECO:0000313|EMBL:PPQ67146.1, ECO:0000313|Proteomes:UP000283269}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2631 {ECO:0000313|EMBL:PPQ67146.1,
RC ECO:0000313|Proteomes:UP000283269};
RX PubMed=30283667; DOI=10.1002/evl3.42;
RA Reynolds H.T., Vijayakumar V., Gluck-Thaler E., Korotkin H.B.,
RA Matheny P.B., Slot J.C.;
RT "Horizontal gene cluster transfer increased hallucinogenic mushroom
RT diversity.";
RL Evol. Lett. 2:88-101(2018).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PPQ67146.1}.
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DR EMBL; NHYD01003976; PPQ67146.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A409VLR0; -.
DR STRING; 93625.A0A409VLR0; -.
DR InParanoid; A0A409VLR0; -.
DR OrthoDB; 922060at2759; -.
DR Proteomes; UP000283269; Unassembled WGS sequence.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR GO; GO:0007015; P:actin filament organization; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProt.
DR GO; GO:0007034; P:vacuolar transport; IEA:UniProt.
DR CDD; cd14232; GAT_LSB5; 1.
DR CDD; cd16980; VHS_Lsb5; 1.
DR Gene3D; 1.20.58.160; -; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR044103; GAT_LSB5.
DR InterPro; IPR038425; GAT_sf.
DR InterPro; IPR045007; LSB5.
DR InterPro; IPR002014; VHS_dom.
DR PANTHER; PTHR47789; LAS SEVENTEEN-BINDING PROTEIN 5; 1.
DR PANTHER; PTHR47789:SF1; LAS SEVENTEEN-BINDING PROTEIN 5; 1.
DR Pfam; PF00790; VHS; 1.
DR SMART; SM00288; VHS; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF89009; GAT-like domain; 1.
DR PROSITE; PS50179; VHS; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000283269}.
FT DOMAIN 383..512
FT /note="VHS"
FT /evidence="ECO:0000259|PROSITE:PS50179"
FT REGION 17..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 156..220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 505..565
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 675..807
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 166..184
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 185..220
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 524..565
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 675..695
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 696..711
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 754..770
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 788..807
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 807 AA; 90064 MW; 6713B321B01A5D6A CRC64;
MSFQHFRLGE LPLHQPLQQQ STSQQQPSNV SASKQPYGSG DTDDGYTLVF SNIAAFQDWR
ASEEEQHCVE FVKGDTHGSK ADPPRFKDHT KLVCARHSRS GRKKYVKKHP ERVRKVPSRK
LDGQGCQASI SYKTYFDTEE VRACYISQHS HEIGPANLPF TRRGRKAAVQ NEKERGRNKS
VAASDHHHQQ VASSSNVPTN ITHQTPLHHH QQQQQQVPGV SFSSAVSMLA PLPGQAFPAQ
TAQPYSYPSS VSPFASLQNQ QPLQNQQQPL PHERWENMAT LFQTIRDHAR AFEYPPASVA
ALETVLIRLY LESPMGISPQ HTMGHVLNLA RVPAGRNRLP QVRNPLCNPL SSSSSNMSAL
NFARQAFGRE KPHSSITDWV EILTSGNIEE EAYDGIPELV DSINLQASGP AEASRALRKK
LKHGNSHQQY RSLVILKALV ENCGQKFQST FADGQLTDTI KNLSNDPSTD RRVKKKLSLV
LASWHEQYKD DPSMAAVTSL YKPRREEPKR LNHQELSDMM GLNLSAEEKR RAEKQETKKR
EKKEKKEREE KARQEEENRH KKKREPFEFE KHKAVVLASI VDASQASSNL VNAITLVNLA
TDSLETNERV QECLQKAKQA RKAVVRYIQL VENEEVIGTL IETNERIMSA LETYDSLVGS
TGKADGTGAI ATTLATTQIS SPESNTTPNL ENTTKGKERS AADHPTHLHP DLEDLSFGAL
GGASSRLPAP MRPSNTLSDD EQEIPSHRGS LSEYSDYESS DEETHKRNAG SSTRRAYVTV
SDNEDAPLAT KGRAREVDPF ADPFADT
//
