ID A0A409VMK5_PSICY Unreviewed; 778 AA.
AC A0A409VMK5;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE RecName: Full=Protein arginine N-methyltransferase {ECO:0000256|PIRNR:PIRNR015894};
GN ORFNames=CVT25_006024 {ECO:0000313|EMBL:PPQ67483.1};
OS Psilocybe cyanescens.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Strophariaceae; Psilocybe.
OX NCBI_TaxID=93625 {ECO:0000313|EMBL:PPQ67483.1, ECO:0000313|Proteomes:UP000283269};
RN [1] {ECO:0000313|EMBL:PPQ67483.1, ECO:0000313|Proteomes:UP000283269}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2631 {ECO:0000313|EMBL:PPQ67483.1,
RC ECO:0000313|Proteomes:UP000283269};
RX PubMed=30283667; DOI=10.1002/evl3.42;
RA Reynolds H.T., Vijayakumar V., Gluck-Thaler E., Korotkin H.B.,
RA Matheny P.B., Slot J.C.;
RT "Horizontal gene cluster transfer increased hallucinogenic mushroom
RT diversity.";
RL Evol. Lett. 2:88-101(2018).
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. {ECO:0000256|PIRNR:PIRNR015894}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PPQ67483.1}.
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DR EMBL; NHYD01003973; PPQ67483.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A409VMK5; -.
DR STRING; 93625.A0A409VMK5; -.
DR InParanoid; A0A409VMK5; -.
DR OrthoDB; 5489665at2759; -.
DR Proteomes; UP000283269; Unassembled WGS sequence.
DR GO; GO:0016274; F:protein-arginine N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.20.20.150; Divalent-metal-dependent TIM barrel enzymes; 1.
DR Gene3D; 2.70.160.11; Hnrnp arginine n-methyltransferase1; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR025799; Arg_MeTrfase.
DR InterPro; IPR007857; Arg_MeTrfase_PRMT5.
DR InterPro; IPR035075; PRMT5.
DR InterPro; IPR035248; PRMT5_C.
DR InterPro; IPR035247; PRMT5_TIM.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR10738; PROTEIN ARGININE N-METHYLTRANSFERASE 5; 1.
DR PANTHER; PTHR10738:SF0; PROTEIN ARGININE N-METHYLTRANSFERASE 5; 1.
DR Pfam; PF05185; PRMT5; 1.
DR Pfam; PF17286; PRMT5_C; 1.
DR Pfam; PF17285; PRMT5_TIM; 1.
DR PIRSF; PIRSF015894; Skb1_MeTrfase; 2.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51678; SAM_MT_PRMT; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000256|PIRNR:PIRNR015894};
KW Reference proteome {ECO:0000313|Proteomes:UP000283269};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PIRNR:PIRNR015894};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR015894}.
FT DOMAIN 50..307
FT /note="PRMT5 TIM barrel"
FT /evidence="ECO:0000259|Pfam:PF17285"
FT DOMAIN 354..515
FT /note="PRMT5 arginine-N-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF05185"
FT DOMAIN 518..776
FT /note="PRMT5 oligomerisation"
FT /evidence="ECO:0000259|Pfam:PF17286"
FT ACT_SITE 486
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR015894-1"
FT ACT_SITE 495
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR015894-1"
FT BINDING 380
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PIRSR:PIRSR015894-2"
FT BINDING 389..390
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PIRSR:PIRSR015894-2"
FT BINDING 443
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PIRSR:PIRSR015894-2"
FT BINDING 470..471
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PIRSR:PIRSR015894-2"
FT SITE 383
FT /note="Critical for specifying symmetric addition of methyl
FT groups"
FT /evidence="ECO:0000256|PIRSR:PIRSR015894-3"
SQ SEQUENCE 778 AA; 86542 MW; 96E79B8D21D66B82 CRC64;
MDYQESWDHC ATLSTSLTLS DISKACRGLS DFQGDETAVL KVIGDSKQKG YKRVCMPLTT
EKWKERWSKM CLLPNESSDE DKESASKAAE AWRLNPAFQR DEVTITRLDE AEGIIVMVSE
WLELDAADDW VRHDAEIALK QELAYASYLN IHTVILPSPR NRDHVASYAR IVNSCLTKFP
YIYISIRLPI YNPSVFQPSS PSSPVLRPTS PPMHASLGSS SSIAPSLVIS ESEQLPASNS
GVSLNATWEM WDLIRTMCDY NMKLTLTLDL SPALPTTLGV LSKWAAESVR HIFLPASTFI
ANVKGYPHRP MIILAEVGEG RHTRGGENAY SQYVRHLEKT SPAVQAAKKA GTVENFAQGY
QDYLQAPLQP LMDNLPSITY QTFEQDPIKY MQYEEAMFRA FLDHPVDEKL VVCVAGAGRG
PLVARCFKAL ERSNREATVI AVEKNPNAFV TLQERQIKEW GNKVQLIFGD MRLIDVPEKA
DILVSELLGS FGDNELSPEC LDGAMRFLKP TGISIPSSYT AHLAPLSSSK LYNEARSTKT
EKGLETPYVV MFQAVNILSG TKASADGRCG PQVQECWEFE HPRRDAVLDS QGLPFTNSHN
ARSAKLRFYI PHAGILHGLA GYFEAVLYGN IGISIHPHRK DQVSKDMLSW FPLFFPFREP
LYLPSSSELQ VSIWRITNDR RVWYEWHAES FISVPNSAGT SEELLMGQPF SGSFSASSSS
FSSMGAPSPL VDSKEPAFLD MTRMNTNYAG SGGVEYETVK IGHTSLHNAG GRSSWIGL
//