ID   A0A409W6K5_9AGAR        Unreviewed;       696 AA.
AC   A0A409W6K5;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   24-JAN-2024, entry version 13.
DE   RecName: Full=serine C-palmitoyltransferase {ECO:0000256|ARBA:ARBA00013220};
DE            EC=2.3.1.50 {ECO:0000256|ARBA:ARBA00013220};
GN   ORFNames=CVT26_006764 {ECO:0000313|EMBL:PPQ74160.1};
OS   Gymnopilus dilepis.
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Agaricomycetidae; Agaricales; Agaricineae; Hymenogastraceae; Gymnopilus.
OX   NCBI_TaxID=231916 {ECO:0000313|EMBL:PPQ74160.1, ECO:0000313|Proteomes:UP000284706};
RN   [1] {ECO:0000313|EMBL:PPQ74160.1, ECO:0000313|Proteomes:UP000284706}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SRW20 {ECO:0000313|EMBL:PPQ74160.1,
RC   ECO:0000313|Proteomes:UP000284706};
RX   PubMed=30283667; DOI=10.1002/evl3.42;
RA   Reynolds H.T., Vijayakumar V., Gluck-Thaler E., Korotkin H.B.,
RA   Matheny P.B., Slot J.C.;
RT   "Horizontal gene cluster transfer increased hallucinogenic mushroom
RT   diversity.";
RL   Evol. Lett. 2:88-101(2018).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + hexadecanoyl-CoA + L-serine = 3-oxosphinganine + CO2 +
CC         CoA; Xref=Rhea:RHEA:14761, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:33384, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379,
CC         ChEBI:CHEBI:58299; EC=2.3.1.50;
CC         Evidence={ECO:0000256|ARBA:ARBA00001016};
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933};
CC   -!- SIMILARITY: Belongs to the class-II pyridoxal-phosphate-dependent
CC       aminotransferase family. {ECO:0000256|ARBA:ARBA00008392}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PPQ74160.1}.
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DR   EMBL; NHYE01005359; PPQ74160.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A409W6K5; -.
DR   STRING; 231916.A0A409W6K5; -.
DR   InParanoid; A0A409W6K5; -.
DR   OrthoDB; 9643at2759; -.
DR   Proteomes; UP000284706; Unassembled WGS sequence.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0016740; F:transferase activity; IEA:InterPro.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   CDD; cd06454; KBL_like; 1.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 2.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR001917; Aminotrans_II_pyridoxalP_BS.
DR   InterPro; IPR004839; Aminotransferase_I/II.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   PANTHER; PTHR13693; CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE; 1.
DR   PANTHER; PTHR13693:SF3; LD36009P; 1.
DR   Pfam; PF00155; Aminotran_1_2; 2.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR   PROSITE; PS00599; AA_TRANSFER_CLASS_2; 1.
PE   3: Inferred from homology;
KW   Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW   Reference proteome {ECO:0000313|Proteomes:UP000284706}.
FT   DOMAIN          247..495
FT                   /note="Aminotransferase class I/classII"
FT                   /evidence="ECO:0000259|Pfam:PF00155"
FT   DOMAIN          557..658
FT                   /note="Aminotransferase class I/classII"
FT                   /evidence="ECO:0000259|Pfam:PF00155"
SQ   SEQUENCE   696 AA;  75805 MW;  39688D917CF2B99A CRC64;
     MPSKSPSPMA FTKPAQSPSI FKKRSASALS SLPASAASYL SALSQADARA RSANNNSPTS
     TPALSLSSSI TSSSEDTILH EDDYMNDPVL GSNKDGLLLP SRPPTSEQVF STVHTEFGHC
     ASEEYRMTSQ HPPGKPLAVH VPKDPPYYIL LSTYISYLIL IVLGHVRDFV GKRLNPGSYK
     HLMPRDGYAP LNSDFDSFYT RRLKTRMDEC FSQPVTGVAG RTILLLDRIS PDYNHSYVFT
     GSRTRALNIS SYNYLGFAQA RGGCADAVEE SIRRYGISTL GSRLEAGNSD LHVVSEALVA
     KFVGMEDALI SSMGFATNST FIPALVSKGC LVISDEFNHA SIRFGVRISG ANVRMFKHND
     MKSLESLLRE VISQGQPKTH RPWKKILVIV EGLYSMEGTL VNLPAIVELK KKYKFYLFVD
     EAHSIGALGP HGRGVADYFG INPRAIDILM GTFTKSFGAA GGYIAGNKAL IDRLRVYGHS
     GPYAEAMTPP VLTQVIASMA SIMGLKPSGA AGSGSTSEQL LVPRGSVPPA QALDDEYHHP
     GPAPASSLPA WISLPAALSS GAEGRTRLRR LAFNARYLHH GLRKLGFITY GHPTSPIVPL
     LIFNPGKMNM FHRLMKERQT PIIVVVVAYP ATPLVTSRVR FCVSAAHTKE DVDTVLRACD
     EIGDVLDLKH GIPKRERWSI EEVVRRAVEL GTSEEE
//