ID A0A409WBS5_9AGAR Unreviewed; 747 AA.
AC A0A409WBS5;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=Xaa-Pro aminopeptidase P {ECO:0008006|Google:ProtNLM};
GN ORFNames=CVT26_006092 {ECO:0000313|EMBL:PPQ75972.1};
OS Gymnopilus dilepis.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Hymenogastraceae; Gymnopilus.
OX NCBI_TaxID=231916 {ECO:0000313|EMBL:PPQ75972.1, ECO:0000313|Proteomes:UP000284706};
RN [1] {ECO:0000313|EMBL:PPQ75972.1, ECO:0000313|Proteomes:UP000284706}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SRW20 {ECO:0000313|EMBL:PPQ75972.1,
RC ECO:0000313|Proteomes:UP000284706};
RX PubMed=30283667; DOI=10.1002/evl3.42;
RA Reynolds H.T., Vijayakumar V., Gluck-Thaler E., Korotkin H.B.,
RA Matheny P.B., Slot J.C.;
RT "Horizontal gene cluster transfer increased hallucinogenic mushroom
RT diversity.";
RL Evol. Lett. 2:88-101(2018).
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SIMILARITY: Belongs to the peptidase M24B family.
CC {ECO:0000256|ARBA:ARBA00008766}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PPQ75972.1}.
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DR EMBL; NHYE01005209; PPQ75972.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A409WBS5; -.
DR STRING; 231916.A0A409WBS5; -.
DR InParanoid; A0A409WBS5; -.
DR OrthoDB; 869at2759; -.
DR Proteomes; UP000284706; Unassembled WGS sequence.
DR GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR CDD; cd01085; APP; 1.
DR Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 2.
DR InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR InterPro; IPR000587; Creatinase_N.
DR InterPro; IPR000994; Pept_M24.
DR InterPro; IPR033740; Pept_M24B.
DR InterPro; IPR032416; Peptidase_M24_C.
DR PANTHER; PTHR43763:SF21; X-PRO AMINOPEPTIDASE; 1.
DR PANTHER; PTHR43763; XAA-PRO AMINOPEPTIDASE 1; 1.
DR Pfam; PF01321; Creatinase_N; 1.
DR Pfam; PF16189; Creatinase_N_2; 1.
DR Pfam; PF00557; Peptidase_M24; 1.
DR Pfam; PF16188; Peptidase_M24_C; 1.
DR SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000284706}.
FT DOMAIN 91..246
FT /note="Creatinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01321"
FT DOMAIN 440..674
FT /note="Peptidase M24"
FT /evidence="ECO:0000259|Pfam:PF00557"
FT DOMAIN 686..747
FT /note="Peptidase M24 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16188"
SQ SEQUENCE 747 AA; 83865 MW; 904DFED788A99F76 CRC64;
MWRQSQVWCR VRPAQKPSHI RALHLLSRSP SSSSVSLVLS GRSQRQEVLR TFCASSIIGS
VRSNTTSPPS ERDDIESMGA VGQQTVNTTE RLAKLRELMR KYGVQAFVVP SEDQHAIIFD
FHVRSVLFCL LACLFATDSS EYLAHCDERR AFISGFNGSA GCAVVTLDKA HLFTDGRYFL
QAAKQLDENW VLMKQGLPDV PTWQEFLHKN LEPKTKIGID PTLISASDAE SLNKKLAEKE
SELVSLPQNL VDAVWGADRP TRPKNRVFHL DEKYSGQSHR DKVAKIWEEL EKKKAKALVV
TMLDEVAWLF NLRGSDIDFN PGIFYCSYQS FSELIFLAVF FSYAVLTKDK VTLFVESEQL
DSSAQKYLEG GQVEVKPYGG FFEYLKALAG TLDLKDDWKI LIGDKASLAV AEALGKGTYT
IARSPVTDLK AIKNETELEG FRQSHIRDGA ALARYFAWLE EQLNNGAKLS ESQAADQLEK
YRSELDLFQG LSFTTISSTG PNGGELFEAE FDFLDSERFE AIIHYSPDPN DCDIIKKEQV
YLCDSGGQYL DGTTDVTRTW HFGTPSDEEK RAFTRVLQGN IAIDTAVFPV GTTGYIIDSW
ARRALWQDGL DFRHGTGHGV GHFLNVHEGP QGIGTRITLN SAPLKAGMTV SNEPGYYADG
RFGIRIENIV LVREAKTPNN FGDKGYLCFE NVTMCPIQKK LIDTSLLSEL EKKWLDAYHK
ETFEKVSPLL KNDPRALEWL KRECSPL
//
