ID A0A409WDP6_9AGAR Unreviewed; 1708 AA.
AC A0A409WDP6;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 13.
DE RecName: Full=ATP-dependent DNA helicase {ECO:0000256|RuleBase:RU363044};
DE EC=3.6.4.12 {ECO:0000256|RuleBase:RU363044};
GN ORFNames=CVT24_013026 {ECO:0000313|EMBL:PPQ76590.1};
OS Panaeolus cyanescens.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Galeropsidaceae; Panaeolus.
OX NCBI_TaxID=181874 {ECO:0000313|EMBL:PPQ76590.1, ECO:0000313|Proteomes:UP000284842};
RN [1] {ECO:0000313|EMBL:PPQ76590.1, ECO:0000313|Proteomes:UP000284842}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2629 {ECO:0000313|EMBL:PPQ76590.1,
RC ECO:0000313|Proteomes:UP000284842};
RX PubMed=30283667; DOI=10.1002/evl3.42;
RA Reynolds H.T., Vijayakumar V., Gluck-Thaler E., Korotkin H.B.,
RA Matheny P.B., Slot J.C.;
RT "Horizontal gene cluster transfer increased hallucinogenic mushroom
RT diversity.";
RL Evol. Lett. 2:88-101(2018).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|RuleBase:RU363044};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|RuleBase:RU363044};
CC -!- SIMILARITY: Belongs to the helicase family.
CC {ECO:0000256|RuleBase:RU363044}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PPQ76590.1}.
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DR EMBL; NHTK01005556; PPQ76590.1; -; Genomic_DNA.
DR STRING; 181874.A0A409WDP6; -.
DR InParanoid; A0A409WDP6; -.
DR OrthoDB; 1652757at2759; -.
DR Proteomes; UP000284842; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR CDD; cd18809; SF1_C_RecD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR010285; DNA_helicase_pif1-like.
DR InterPro; IPR046700; DUF6570.
DR InterPro; IPR025476; Helitron_helicase-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR47642; ATP-DEPENDENT DNA HELICASE; 1.
DR Pfam; PF20209; DUF6570; 1.
DR Pfam; PF14214; Helitron_like_N; 1.
DR Pfam; PF05970; PIF1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU363044};
KW DNA damage {ECO:0000256|RuleBase:RU363044};
KW DNA recombination {ECO:0000256|RuleBase:RU363044};
KW DNA repair {ECO:0000256|RuleBase:RU363044};
KW Helicase {ECO:0000256|RuleBase:RU363044};
KW Hydrolase {ECO:0000256|RuleBase:RU363044};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU363044};
KW Reference proteome {ECO:0000313|Proteomes:UP000284842}.
FT DOMAIN 2..109
FT /note="DUF6570"
FT /evidence="ECO:0000259|Pfam:PF20209"
FT DOMAIN 240..464
FT /note="Helitron helicase-like"
FT /evidence="ECO:0000259|Pfam:PF14214"
FT REGION 1618..1644
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1679..1708
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1630..1644
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1708 AA; 193881 MW; 3610EE76DAE2D19B CRC64;
MLSLCRGKTT VVQLTEIDGK QSNAVSQRAL KGNIIIFPQD PSEIATSLPV PPHDVARHVC
IVFIGSSNPS REWLLEKAKP LLIRPDVMRP ALMWLKAKNP LYRHIQTDFQ LLQSLPAESV
LPVDIHRYGN MASFVKFTSD YDPSSNVRHD DDVYEDSIEF ERTCIPESAD VTTPANMRVA
AAVHLKQGGS FLPVPHSSRP CNEFKNTSLF PMIYPTLYPY GIGGFENEMR TVPVSIHRHI
QLLLNYADDR FQVHHSFMFT VFNILQRRQV LLHTHNRVQN RQFRDFAQRF SSVSAEAVAE
YAEKMKDSSS HFDSTEQDQL ISRLLSEINI VTQNVSGTPA AKKKLRNQLR ALILQKGLPT
FFITLNPADI YNPILSFLSG RQIDPENMQE ADIPQYFEQA RFIARNPVVT AKFFDMYMRA
FFDHLLTYTD DEDLVENGIL GKTDAYYGCV EAQGRGSLHC HMMVWLKGSI NPTELKSRIL
NDDQFCESFI RYLESVIATE VPADPLPRTQ SLFSNHHPCK LRPPDGSTYN SNRALFTHDL
HYLAEACQRH VHTETCFKYS KSSHNERECR FNLGPSCAQP STVVVQETGE IKLQHKDGTI
NNFNPIILSA MRCNMDIKFI GSGTCAKALL YYVTDYITKS PLKAHVAYSA LETAIQHLSD
VDTSDSNTID HSKMLLNKSA FALLSRQELS AQEIAMSLLQ IDDHYTSHEF RTFYWPELQY
RRFDRSNMET DLDLDVSAHV SSPPPNTENP MNFEDTNLDD DYEVEIESDE QGFLFKKASY
LDDYKYRSES LRDVSLWDFV SQFTRVRKPY RSTTDPVSRN SRGSFFDFQP DHPQYQSCRI
KRLPISKSVV PTPVGKLLPR RDRPASYAEY CYIMLCLFSP WSSQEELDHF RRNGSEIFAE
KLSNMEPSIQ SVIENIQLLH ECKDSKEDDY YSRRRNHSDH DSNLVVSGNQ PLLLGNSDDL
TLEDVQQQLA VEHVQRLLNC RSQRNSVRSA QTESIIAAAN QVQLFKSDYE QTSLHDSSTT
CVTGDTSIED IWEAEYKQRR KNWRKNAFDV ENNQRTTHSN ATSYNSTFTF HNAQRLPHCN
PSSLETYGHA CSTTASCAYH SPKPVTELTH YAHQIISKYK LNQNQCYAFE LVSQTLMQEL
NGGKPDQLRM ALMGAGGTGK STVIRALSDL FSTLNRDYLL KKCAYTGVAS NNIKGITLYS
ALGLSRTSYD SNTKLHREIA ALWENTKFLI VDEVSMLGCQ NMYKLSSALC AAKGSEEPFG
GIHILFAGDF AQLSPIMEKS LFDHLDTSST ATPHVQRNAF GKLLWYSVSS VVELTEVMRQ
NSSEEQQFLA LLHRLRLGKC TVEDHKLLST RVLHRLPECE RPQGIDSTTL VYSNEAKDAL
NEMATISYSQ ATGKPVHWYY ARDFVNGCAV PIGSDFHHLL RKMHGVSTAY RLTAIPLVIG
MPVMLMNNLD VPGGAMNGAI GQLKSIRYTT DADGFRYLQS CVINTEDVKG EPLTNLQNGD
IACFLDTKKL TLEHPYSHKN ITVSRKQLPI CPAFASTVHK AQGLTLPRAI VDLHGCPTGA
SECPYVMLSR VRSLKNLFLL RDFDLTKLRC RPSEDIRKEY QRLTDLHFAT LKRNNFDTAS
STRDSTLTSG ESTDHWRDEP DSDPVPSYSH LNFSWNSNSI DKKRMLSTLA EVQNSTFHTE
LSKNQKKRST ATLEESTSST SVVKKRRL
//
