ID A0A409WGJ3_PSICY Unreviewed; 1604 AA.
AC A0A409WGJ3;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Dicer-like protein 1 {ECO:0008006|Google:ProtNLM};
GN ORFNames=CVT25_011393 {ECO:0000313|EMBL:PPQ77601.1};
OS Psilocybe cyanescens.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Strophariaceae; Psilocybe.
OX NCBI_TaxID=93625 {ECO:0000313|EMBL:PPQ77601.1, ECO:0000313|Proteomes:UP000283269};
RN [1] {ECO:0000313|EMBL:PPQ77601.1, ECO:0000313|Proteomes:UP000283269}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2631 {ECO:0000313|EMBL:PPQ77601.1,
RC ECO:0000313|Proteomes:UP000283269};
RX PubMed=30283667; DOI=10.1002/evl3.42;
RA Reynolds H.T., Vijayakumar V., Gluck-Thaler E., Korotkin H.B.,
RA Matheny P.B., Slot J.C.;
RT "Horizontal gene cluster transfer increased hallucinogenic mushroom
RT diversity.";
RL Evol. Lett. 2:88-101(2018).
CC -!- SIMILARITY: Belongs to the helicase family. Dicer subfamily.
CC {ECO:0000256|PROSITE-ProRule:PRU00657}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PPQ77601.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; NHYD01003436; PPQ77601.1; -; Genomic_DNA.
DR STRING; 93625.A0A409WGJ3; -.
DR InParanoid; A0A409WGJ3; -.
DR OrthoDB; 342391at2759; -.
DR Proteomes; UP000283269; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0004525; F:ribonuclease III activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR CDD; cd00593; RIBOc; 2.
DR Gene3D; 1.20.1290.10; AhpD-like; 1.
DR Gene3D; 3.30.160.380; Dicer dimerisation domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.1520.10; Ribonuclease III domain; 3.
DR InterPro; IPR029032; AhpD-like.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR038248; Dicer_dimer_sf.
DR InterPro; IPR005034; Dicer_dimerisation_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000999; RNase_III_dom.
DR InterPro; IPR036389; RNase_III_sf.
DR PANTHER; PTHR14950; DICER-RELATED; 1.
DR PANTHER; PTHR14950:SF37; ENDORIBONUCLEASE DICER; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF03368; Dicer_dimer; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00636; Ribonuclease_3; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00535; RIBOc; 1.
DR SUPFAM; SSF69118; AhpD-like; 1.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF69065; RNase III domain-like; 2.
DR PROSITE; PS51327; DICER_DSRBF; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS00517; RNASE_3_1; 1.
DR PROSITE; PS50142; RNASE_3_2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000283269};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00657};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 88..107
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..170
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 342..505
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 528..628
FT /note="Dicer dsRNA-binding fold"
FT /evidence="ECO:0000259|PROSITE:PS51327"
FT DOMAIN 911..1055
FT /note="RNase III"
FT /evidence="ECO:0000259|PROSITE:PS50142"
FT DOMAIN 1093..1211
FT /note="RNase III"
FT /evidence="ECO:0000259|PROSITE:PS50142"
SQ SEQUENCE 1604 AA; 180152 MW; F254048A869C534A CRC64;
MIGNVIAAMD TGSGKTLISL LLIKWISSQE KSAGKIITFL VPKVALVEQQ HAFFAKNSSL
RVAKLYGAQD LDLSDRIGWK ERFEGCDVLV MTGIIHFFSV ACLFLMMNKV SLMIFDECHH
ARKNHPYNGI LREYFHNPSH LRPKIFGMTA SPIWNIRDPR GSLAVLERNL DAKVTAVRDH
VQELVSYAPK AMELIKVYPH PPEEYNFPSP TLYQCLKVID IPAWDQLDIP WTNIETRYVV
TLNDLGPYCA SLFLHQEIHH HVSRVIVENK QTVIEKFDNV MEIEGILPFP NSSSSTLPDD
FALIIDILYE FETIFPTETT SQPIPLSVTL DWCTPKVKLL VNILAEYYAH TPAFQCIVFV
EQRQVASSLS MVLQAIPDLH GKIKCAFLTG QGVNSDGLSK QTDRHHGDPV KLFRDRVINI
LVATSVAEEG LDFKECDLVV RFDPPHHMVG YVQSRGRARK DGSTFVVMIQ QNDTAQLEKY
QALKQKEPEV NYVYQTRHME IDNSEDVDSE DETDPVDLMA RERYVVPSTG AVLNYDNSLN
LLNYLCSLIP RDAFTTAHVP VYGGDFGATL QLPRALPLLP EDLFFSGPIR RSKKEARRAV
AFKAVKRLKE LDVFDDYLLP MAKHSEDGQE IGEKHRHKKT KRPEVPVNMN VSVRDPWCVG
HKLWLHPIFL GDRAIAGLVT GTPLCPDEAI ISGHQVKSLP AKLLTFEKDY EYEQRMAMHE
FTRLGIWYNI TSRPLTGALS LYLVPITSEY LPDFEAIGLL LSNPRGCSDW SRISEEHYEQ
LVVISLNHWG SFHLLRRIRD DLSPMSIPTS GSREASGSTY YEYWMTKWTR KRRQALLHCD
GPLLETLRRP RSNLGAYHMD PSLQNVTVLS VPNGRLLPRN GCTWLPMSVS MLQAFDVLPV
VCRRLTDGYR ARAVRCELGI PVISISLIIE AFTIPSAIMP FNNQRLETLG DAVLKLCTTV
HLLNKYPNRH EGQLSNLRQK YVQNHFLLHR ALDLGFERFV NAEIASVLKW RYLLETNASI
GRSSSPERSI NSVYPRRSLQ DCMEAILGAS FVAGGIPLSL HTGTALGLEF GGPLPWFTRY
NQNIEPTPIA PLFASLEKIL GYKFRYNHLV LESLSHPSFT DSDVPSYQRL EFLGDGVYDS
PTSHLAVKKL GLHKMMLTNS VDLNLAIDRY TPLLENISGD EIVKSGWKYD PPKALSDVFE
SVMGAVLVDS GYDYEKTAAI VEYVMADVLE ALSPAVDKDP VSELMEWTAG AGCRVIAFEK
KIKTLDILEQ EGIAVTVHGT TIVGPIVSAS LTVAKFAAAE RALAILKDPM SQNSLLCLCD
CAFAMQRHLF QLANYFLKMT LPLTVSSTFL NTLKSLFPGF SKVDGGRGTA VTNARNDRSE
GESPVFQNPW YIVAAVAFSA SNRPEGVKYV FEHVLQDLGR HHDEESLKKE SKKLAQKLRE
ALFKSGMTLV VKAINSLQAL NAVITDDWKE TEIQRFVEDT DISLAEYETK GQTVFRSIYG
DTADSVDGLL TSIYPDMDFT GWFSRTIGYG LVYGHISTLS TLETSYTLVA ALIAGDTPQQ
IGWHLDGAKR GGATTEEVRA VRQLSIEVAK FSGIQWKHDV PEVN
//
