ID A0A409WH05_PSICY Unreviewed; 1383 AA.
AC A0A409WH05;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE RecName: Full=SSD domain-containing protein {ECO:0000259|PROSITE:PS50156};
GN ORFNames=CVT25_011145 {ECO:0000313|EMBL:PPQ77710.1};
OS Psilocybe cyanescens.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Strophariaceae; Psilocybe.
OX NCBI_TaxID=93625 {ECO:0000313|EMBL:PPQ77710.1, ECO:0000313|Proteomes:UP000283269};
RN [1] {ECO:0000313|EMBL:PPQ77710.1, ECO:0000313|Proteomes:UP000283269}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2631 {ECO:0000313|EMBL:PPQ77710.1,
RC ECO:0000313|Proteomes:UP000283269};
RX PubMed=30283667; DOI=10.1002/evl3.42;
RA Reynolds H.T., Vijayakumar V., Gluck-Thaler E., Korotkin H.B.,
RA Matheny P.B., Slot J.C.;
RT "Horizontal gene cluster transfer increased hallucinogenic mushroom
RT diversity.";
RL Evol. Lett. 2:88-101(2018).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PPQ77710.1}.
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DR EMBL; NHYD01003434; PPQ77710.1; -; Genomic_DNA.
DR STRING; 93625.A0A409WH05; -.
DR InParanoid; A0A409WH05; -.
DR OrthoDB; 2786103at2759; -.
DR Proteomes; UP000283269; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015918; P:sterol transport; IEA:UniProt.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR032190; NPC1_N.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR45727; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR PANTHER; PTHR45727:SF2; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR Pfam; PF16414; NPC1_N; 1.
DR Pfam; PF02460; Patched; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000283269};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 232..253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 336..365
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 693..715
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 721..743
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 814..833
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 839..864
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 916..937
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1186..1203
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1210..1232
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1238..1260
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1281..1302
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1322..1345
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 611..864
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 1383 AA; 152606 MW; 33E4D2AFE35EBF7D CRC64;
MRGSCGKKGF FGKPLPCPYD GPPVELNTSA RQLLQDVCGP ELTGGPTCCT EDQIETLQLN
FDQVEPILST CPACRNNFRT FFCSFTCSPE QSSFLNVTST QEISAGKIAV ESLDFFVQEQ
YGRGFFDSCK SVQYGNTNGY VMDIIGGGAQ NYSSFLESLG EEKPLGSPFQ INFPLNSPPD
IQKLNKTARN CADDDLSSRC TCIDCPSVCP NIAPVLPPNE IPTCHVGNLS CLSFILILTY
SLAVLGFLLG YFVQITIRRR RERTYERVAL SADAASPRVH TRGLVGAGSL AQNLDEDSLG
AQSESRHLGR GASLLDPIET VQPRHYRLNS ILRRGFYRLG LFTASSPWLT FAAVFLVVGL
LNIGWKKFEV ETDPVRLWVS PSSESKQQKE FFDNKFGPFY RTEQIFVTSV ATNVEVISNF
TSSSQYSSQA IVIGNKKPVL TWDHLKYWFD VEADIRGLKS TNGHTLRDVC FKPEGPRGAC
VVQSVAAWFE NDLENYDEES WVPRLQRCAN SPVDCLPEFK QPLAPQYVLG GVPVTEDDRK
KYLDAEALVV TYVVSDSLDP KIKARAMEWE EALREYLVNL KQRVVNEAGL EIAFSTGVSL
EEEINKSTNT DVKIVVLSYL AMFFYVSLTL GSGTPGREED GVISSLLEWG RNFPKLFART
SITASTLSVD SRTTPRLFPR LPRSLFVGSK FTLGLFGILL VILSVSTSVG LFSFLGVKVT
LIIAEVIPFL VLAVGVDNVF ILVHELDRQN FLHGPNASAQ AYQGPGFSAP MSPTYSHRSP
FDSTHDEIDA ASMPLYLVPE ERVARTLAKM GPSILLSTIT ETLAFALGAL VPMPAVRNFA
LYAAGSVLLN ATLQVTVFMS ALLLDLKRYE DSRVDCFPCI RLPPRIALLD APNTSSGLGT
IARFIRRYYA PFLLKPFTKA AVLISFSGIF VASVISIQHI QLGLDQRLAL PSESYLVDYF
DNLDAYLDIG PPVYFVSRDI DVTHRDGQQA LCGRFTTCDD YSVANWLEAE RKRPKSSFIA
EPTASWIDDF LGWLNPSIAT CCRVRIDDPS VFCRPRDSED DCQPCYQDKQ PGWNITMDGL
PENEEFMKYF KQWWISPTDE DCPLAGKASF GSAIALTDTG DKIEASHFRT FHSPLKTQED
FINAFAAAHR IADEISADTG ASVFPYSLFY VFFDQYAHIV AITQEILGLG LAAVLIVTAL
LLGSWRTGSI VTGVVALTVV TVMGVMSIWG ISLNAISLVN LVISLGIAVE FCAHVARAFM
SAGTGLPIDH PSGQKERDER MWTALVDVGP SVLSGITFTK LIGMSVLALT RSKLLEIYYF
RMWLTLIISG ALHGLVLLPV ILSIAGGAGF PQQEADEEWM SNAIRNDYEY TPFLADDESI
ASD
//
