ID A0A409WVX9_PSICY Unreviewed; 1066 AA.
AC A0A409WVX9;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=CSC1/OSCA1-like 7TM region domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=CVT25_009414 {ECO:0000313|EMBL:PPQ82684.1};
OS Psilocybe cyanescens.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Strophariaceae; Psilocybe.
OX NCBI_TaxID=93625 {ECO:0000313|EMBL:PPQ82684.1, ECO:0000313|Proteomes:UP000283269};
RN [1] {ECO:0000313|EMBL:PPQ82684.1, ECO:0000313|Proteomes:UP000283269}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2631 {ECO:0000313|EMBL:PPQ82684.1,
RC ECO:0000313|Proteomes:UP000283269};
RX PubMed=30283667; DOI=10.1002/evl3.42;
RA Reynolds H.T., Vijayakumar V., Gluck-Thaler E., Korotkin H.B.,
RA Matheny P.B., Slot J.C.;
RT "Horizontal gene cluster transfer increased hallucinogenic mushroom
RT diversity.";
RL Evol. Lett. 2:88-101(2018).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PPQ82684.1}.
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DR EMBL; NHYD01003107; PPQ82684.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A409WVX9; -.
DR STRING; 93625.A0A409WVX9; -.
DR InParanoid; A0A409WVX9; -.
DR OrthoDB; 366603at2759; -.
DR Proteomes; UP000283269; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018:SF83; CALCIUM PERMEABLE STRESS-GATED CATION CHANNEL 1; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000283269};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 37..57
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 122..141
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 193..213
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 441..467
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 495..514
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 534..555
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 583..610
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 656..674
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 695..713
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 719..739
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 39..214
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 236..428
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 440..713
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT REGION 306..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 930..958
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 972..998
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1010..1030
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1046..1066
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 940..954
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 975..995
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1066 AA; 119460 MW; CB47DAC01C1580EB CRC64;
MPLGAQLFAA LVGDAPNDGE GGKLPPGSPP TLKFEGPWFT TQLTISLTIG VLSFLIFSYS
RTRWPLLFAP RTKLKGFSPH EAHAHQAFFG WIMPTIRTSE FTVLQIVGLD AAVLLNFFKM
SFYLFSFCSM FAIGILMPIN WKLNKDLNDD DGDWPGDEQD WPTLLRRTVV DPPSNHTTPP
HDWLDLISDA NTYLSAHLIF TYIFTLLALF FIYKNYRRFI RARQLFSLEL VHSIPARTVL
VTSLPHHLQG ERPLAEYFEN MGMAVESVTV CREVGALKTL LDRRTEALLK LENAWVEYVG
NPSTVEEYDP EGSGGGPLVD VDVEGGQQGQ QQQGSRLVVP HRPRPTLRPG WFKPKVDALE
YLEARFKEAD ERVKKKRRLG KFRPTGAAFV TFEKMSSAQI AVQVAHAPSP SQITTYPAPE
PRDIVWSNMA PSQRAIQLRD AFVLGTMGLL FFFWFFPITT LAGLLSYNEI KKTMPWLGRV
IDRNEQVRAI VQNSLPSVAM ISLNGVLPFI LEGLTYVQGY RARSWVEFSL LKKYFLFLLV
NVVFIFLLAT TYWQLVQDLA NSPAKVPEKL AISLQAGRAR HFFLSYVILQ GIGIMPLQLL
NLGVIIPRVF YRMFYTRTPR DFAELNAPPM INYGVVYPQA ILMFVITMLY SIVQPLIVIF
GAIYFGVGYV VYKYKLLFVF YKPYESQGQA WPITFIRLIW GIIIFIVFMI GIFTLRKSYI
LSSLLVPLLV GTVTWSWYVD RTLRPLSKYV GLSAVFEVQR GEETADVVRL RAGHPVTWSQ
SNLNRRRYAQ NDDTLYVAPE DERTDYSQPP MANWYSGVLN TGKRRYGHPA LNGVLPEPWL
PLKKGQSLVN RNGDRSHRHG QREDQAVVLT LRKRYSVGRA RRMSQDGMGM GAVGAGVGAN
SNANANGASA SASGAGGSQI VDPSAVIDPW QDATSAPRRP HPARRAHTHP NHSHTLSHRL
SYDHASGVIM LPDDGEWLGE EDEDEDSEEE EDYGVEGGHG LEQSITESMI SEGGDGVGAG
AGDGPLQGQG MARLSRYGTY FHHPERRRTG AAATATNTLP GAFPVR
//
