ID   A0A409WY82_PSICY        Unreviewed;      1528 AA.
AC   A0A409WY82;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   RecName: Full=GH18 domain-containing protein {ECO:0000259|PROSITE:PS51910};
GN   ORFNames=CVT25_007061 {ECO:0000313|EMBL:PPQ83470.1};
OS   Psilocybe cyanescens.
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Agaricomycetidae; Agaricales; Agaricineae; Strophariaceae; Psilocybe.
OX   NCBI_TaxID=93625 {ECO:0000313|EMBL:PPQ83470.1, ECO:0000313|Proteomes:UP000283269};
RN   [1] {ECO:0000313|EMBL:PPQ83470.1, ECO:0000313|Proteomes:UP000283269}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2631 {ECO:0000313|EMBL:PPQ83470.1,
RC   ECO:0000313|Proteomes:UP000283269};
RX   PubMed=30283667; DOI=10.1002/evl3.42;
RA   Reynolds H.T., Vijayakumar V., Gluck-Thaler E., Korotkin H.B.,
RA   Matheny P.B., Slot J.C.;
RT   "Horizontal gene cluster transfer increased hallucinogenic mushroom
RT   diversity.";
RL   Evol. Lett. 2:88-101(2018).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide
CC         (1->4)-beta-linkages in chitin and chitodextrins.; EC=3.2.1.14;
CC         Evidence={ECO:0000256|ARBA:ARBA00000822};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PPQ83470.1}.
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DR   EMBL; NHYD01003015; PPQ83470.1; -; Genomic_DNA.
DR   STRING; 93625.A0A409WY82; -.
DR   InParanoid; A0A409WY82; -.
DR   OrthoDB; 50378at2759; -.
DR   Proteomes; UP000283269; Unassembled WGS sequence.
DR   GO; GO:0008061; F:chitin binding; IEA:InterPro.
DR   GO; GO:0004568; F:chitinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006032; P:chitin catabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0000272; P:polysaccharide catabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.50.10; -; 1.
DR   Gene3D; 3.20.20.80; Glycosidases; 1.
DR   InterPro; IPR011583; Chitinase_II.
DR   InterPro; IPR029070; Chitinase_insertion_sf.
DR   InterPro; IPR001223; Glyco_hydro18_cat.
DR   InterPro; IPR001579; Glyco_hydro_18_chit_AS.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR11177; CHITINASE; 1.
DR   PANTHER; PTHR11177:SF401; CHITINASE; 1.
DR   Pfam; PF00704; Glyco_hydro_18; 1.
DR   SMART; SM00636; Glyco_18; 1.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR   SUPFAM; SSF54556; Chitinase insertion domain; 1.
DR   PROSITE; PS01095; GH18_1; 1.
DR   PROSITE; PS51910; GH18_2; 1.
PE   4: Predicted;
KW   Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277};
KW   Chitin degradation {ECO:0000256|ARBA:ARBA00023024};
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU000489};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU000489};
KW   Polysaccharide degradation {ECO:0000256|ARBA:ARBA00023326};
KW   Reference proteome {ECO:0000313|Proteomes:UP000283269}.
FT   DOMAIN          104..441
FT                   /note="GH18"
FT                   /evidence="ECO:0000259|PROSITE:PS51910"
SQ   SEQUENCE   1528 AA;  166044 MW;  1BAACAEB9BE140CF CRC64;
     MLPICQLDHV PEIYHAQMEH VVMVLAVSAV LAHRIAVLVC AHRTVTQRLN VDLLPTLRMS
     LVPSPSAVAS LVFAALQTIF VGKAVKAIAG SLRPLHAEQS SATARRIGYY EGWAINRAGK
     CGAYEPEQIA ADTLTHINFA FALISSSYQI IEMTKGDSEL WRRTTALKKG RPALKVYLSI
     GGWTFNDQPT QSIFSNMVGS TANTNTFIKS VLSVMETYAF DGIDVDWEYP VAWDRGGVPA
     DKENYVAFMK AVKSAFTPHK YGLTFTAPSS FWYLQHFDLP GMLKYADWVN VMTYDLHVTE
     IDQAFQLYWR VGVDPKQMVM GMGFYGRSFT LASSDCAHAG CAWTSGGKPG VCSGNSGTLM
     YSEIMSIVST LALPIQIDED AAVAYIAWGN QWVSFDNDQT FGMKTSYAND HCIGGTMIWS
     IDQDDNNYSA LDALYPGISA IDRDTISSNT ACYVADCGAK SCYPDTMVST GYYNPVSGNC
     DLDKGIPAPV CCPDAKERGY KDEKSACVPE CEPYEILVSK DIIGETTNEK CLLGMTALCC
     RNPNLYVPPD CEFTSDDGTC DVGQFSLFTD PVGDGSETCL GGNTRSYCCD PPVDLPAPFS
     DIFPSGVPDN GNDAFHVDLD PDVGLKTSES GTFSTFTETD NENTGAFGEI FIDSPKDSSV
     SSLNLQSDWV LTGCDAQSDQ PQKVAAYCAK PGSLSCQHVF IGGAEHTIVE LPKSCGLGPY
     ARIVSLDTHP NQSALNDYHA KAKPASENVF LLHFDYDFAA IPAENGPIYM RADVTDMPGY
     WDSVVDSPPE RRQWLEERGI WRNPKEKRWW GAFNAWLSKI TTLEVDKSQT RSFFWSDTWN
     IFHAETHCEG PPQFDASLDI SLTGTADMSA RYGFYLQGTV VPPAVTAAYA IIASDATASA
     KFTVKGEAQV TYNSDTVTFA SFGFPGLYYP GLLTVGPSLV LEGYIAGQLS VQGELSTSVS
     YHFPPINYAL GKTGTDVVGP AATPDKPTQG YGYNFGVNVD ISGDVTIHVV PTIQLGISVL
     KGQLIEAEAY IRADLYAGIA MNGSISLASA PKLCIAPHYG LIVQGGVTGN VLYWETSTAP
     FTFYNKDFIF GDVCWSSFSE PSVNVKRDLP RIEKSMGEIA QSHGTPTRPG ARMIQTVGNT
     KREIQPSYEL SKRGAFVPTC PGFLSCPNIN NQIGQDNTDN DIYSDYDPNA DDDSNYRRDF
     VDSDLLNVGV AANSSLIFSP ISTVKVSGCA TIAFEPNAYD KAGTTYWNLA APNTLDGNLR
     AYTTAVGYVS TNSYGREHVY EMQLLTDFIG SLAQSSALWM NAAGTTNFCS WAQTYINNPS
     SYTNINQGKG RSVIDRLKSC QPSNSGSVVS NRMPWLESTA NGMKAKAFAG NTLRSSSTFK
     RYSYSKKVFE IRAATGLISY MTDGTVADQF VAVSNCVKDV WSTFSVAYNA DSTVDAPNKG
     NFNMVSTYRS FITSTTQNML TNLRSAVSQM IGFYSTSAGG DTVQKTVDLN YGTLSAQGTT
     PVSANDLRNS IFSRFTGANF VGAITSRL
//