ID A0A409X825_PSICY Unreviewed; 1097 AA.
AC A0A409X825;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=USP domain-containing protein {ECO:0000259|PROSITE:PS50235};
GN ORFNames=CVT25_012573 {ECO:0000313|EMBL:PPQ86854.1};
OS Psilocybe cyanescens.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Strophariaceae; Psilocybe.
OX NCBI_TaxID=93625 {ECO:0000313|EMBL:PPQ86854.1, ECO:0000313|Proteomes:UP000283269};
RN [1] {ECO:0000313|EMBL:PPQ86854.1, ECO:0000313|Proteomes:UP000283269}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2631 {ECO:0000313|EMBL:PPQ86854.1,
RC ECO:0000313|Proteomes:UP000283269};
RX PubMed=30283667; DOI=10.1002/evl3.42;
RA Reynolds H.T., Vijayakumar V., Gluck-Thaler E., Korotkin H.B.,
RA Matheny P.B., Slot J.C.;
RT "Horizontal gene cluster transfer increased hallucinogenic mushroom
RT diversity.";
RL Evol. Lett. 2:88-101(2018).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PPQ86854.1}.
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DR EMBL; NHYD01002412; PPQ86854.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A409X825; -.
DR STRING; 93625.A0A409X825; -.
DR InParanoid; A0A409X825; -.
DR OrthoDB; 9810at2759; -.
DR Proteomes; UP000283269; Unassembled WGS sequence.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd06143; PAN2_exo; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR InterPro; IPR048841; PAN2_N.
DR InterPro; IPR028881; PAN2_UCH_dom.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR028889; USP_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR15728; DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2; 1.
DR PANTHER; PTHR15728:SF0; PAN2-PAN3 DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2; 1.
DR Pfam; PF20770; PAN2_N; 1.
DR Pfam; PF00929; RNase_T; 1.
DR Pfam; PF13423; UCH_1; 1.
DR SMART; SM00479; EXOIII; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 4: Predicted;
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022839};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000283269};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT DOMAIN 473..827
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 413..448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 433..448
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1097 AA; 122358 MW; 9BC6FC5EC61B24FF CRC64;
MATSYKPLQP PLDPLPLTGF AQEITALAFD PVSDILWTGL ESGTVTAMLG TRGNKGPTFR
VGGNMGVKKI TPGDNYVRAM GNSNDGLGSW NKGGANKWSF RPSPENIITF SNTPPSSSFM
VASLDSLEMA FLSPVTGAPI RRVSTTSLLT HLELSHSMLV SGSSDGFIRV HDPRTGMGRA
NGAENFVKAH SRSIEGFETL GNFIFTTGMG ERLAISTISR SSLYDVRTMR PLPPIPFSAG
PAFIHALPNR TSSLVVISIH GLIHVVDASN PAASIELYQL DFPSYATDNP SYITASAISP
SATYMAFGDN DGRIHIMSQA DGEIPFNGYD GQPVPWANTP TPLPEIQWTK STPLNFIGMP
HFDTQLLSVW PSNLTSKTPS YSPPPRIPPQ ILTSMKYNEN IAYANLPKEL RGRRNMTNAG
PRRGIGRFRS GKNATESEPE TESFDRDDDE VPRIYRRVEI EYSKFGIEDF DFGGLETHIL
HSYTNSVIQI MHYIRPIRQL AKGHTTINCP EEHCLLCEQG FISLMLEDAH GTNCQASNFC
KTVGFLAQGS NAIELMDYGR EGTEVDYAQK IQTFHRFLID RMKSEASTPT QNPALLPYGM
PPQYPSISPI TQILGIAGQN VIMCYTCKGI RETHHVTHIV DLVYPKKTVA SSDLPYLTQS
LKSNEQASNF TSILRSSLFR QITHKATCQL CKQFSNFVSR RSISSHQLPP VLAINASVYN
DESFAFWQDY RNSTFLQPQI SLRGQIGGID DGEEAIYKLR ALVVKITRKD RKSHLVAIVR
VPEAEKQGLN SPWYLFNDFV VTNISQREAL SFQGKWKVPA IVYFERLNVE SILDFSHLTQ
KLDPSILSQD TSISNDRDRS LIKHEFLAPN ELPKPGTLVS IDAEFVLMQQ EETEFRSDGT
KKVLRPARLS LARVSVLRGD GPRQGTPFID DHIHTSETIV DYLTEFSGIE YGDLDPALSK
YTLTPLKLVY KKLRLLVDCG CIFIGHGLSK DFRIINQVID TVDLYFIRAR SRRLSLRFLS
WYILGEHIQT GNHDSIEDAR SALRLYNAYQ ELEGQGLFDQ KLEEIYREGR QYGFKPPALT
TDSEEIISSI SSSHLPS
//
