ID A0A409XDK8_PSICY Unreviewed; 1036 AA.
AC A0A409XDK8;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE RecName: Full=Fe2OG dioxygenase domain-containing protein {ECO:0000259|PROSITE:PS51471};
GN ORFNames=CVT25_010266 {ECO:0000313|EMBL:PPQ88836.1};
OS Psilocybe cyanescens.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Strophariaceae; Psilocybe.
OX NCBI_TaxID=93625 {ECO:0000313|EMBL:PPQ88836.1, ECO:0000313|Proteomes:UP000283269};
RN [1] {ECO:0000313|EMBL:PPQ88836.1, ECO:0000313|Proteomes:UP000283269}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2631 {ECO:0000313|EMBL:PPQ88836.1,
RC ECO:0000313|Proteomes:UP000283269};
RX PubMed=30283667; DOI=10.1002/evl3.42;
RA Reynolds H.T., Vijayakumar V., Gluck-Thaler E., Korotkin H.B.,
RA Matheny P.B., Slot J.C.;
RT "Horizontal gene cluster transfer increased hallucinogenic mushroom
RT diversity.";
RL Evol. Lett. 2:88-101(2018).
CC -!- COFACTOR:
CC Name=L-ascorbate; Xref=ChEBI:CHEBI:38290;
CC Evidence={ECO:0000256|ARBA:ARBA00001961};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PPQ88836.1}.
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DR EMBL; NHYD01002006; PPQ88836.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A409XDK8; -.
DR STRING; 93625.A0A409XDK8; -.
DR InParanoid; A0A409XDK8; -.
DR OrthoDB; 38879at2759; -.
DR Proteomes; UP000283269; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0051213; F:dioxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0031418; F:L-ascorbic acid binding; IEA:InterPro.
DR GO; GO:0016652; F:oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor; IEA:InterPro.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR GO; GO:0044281; P:small molecule metabolic process; IEA:UniProt.
DR CDD; cd19120; AKR_AKR3C2-3; 2.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 2.
DR Gene3D; 2.60.120.620; q2cbj1_9rhob like domain; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR044494; AKR3C2/3.
DR InterPro; IPR018170; Aldo/ket_reductase_CS.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase.
DR InterPro; IPR006620; Pro_4_hyd_alph.
DR InterPro; IPR044862; Pro_4_hyd_alph_FE2OG_OXY.
DR PANTHER; PTHR43827; 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE; 1.
DR PANTHER; PTHR43827:SF3; ALDO-KETO REDUCTASE; 1.
DR Pfam; PF13640; 2OG-FeII_Oxy_3; 1.
DR Pfam; PF00248; Aldo_ket_red; 2.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SMART; SM00702; P4Hc; 1.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 2.
DR PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 2.
DR PROSITE; PS51471; FE2OG_OXY; 1.
PE 4: Predicted;
KW Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW Iron {ECO:0000256|ARBA:ARBA00023004}; Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000283269};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1015..1033
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 583..722
FT /note="Fe2OG dioxygenase"
FT /evidence="ECO:0000259|PROSITE:PS51471"
SQ SEQUENCE 1036 AA; 113182 MW; 3B3763F14BD0561E CRC64;
MPWVPYTLND GNVMPSIAYG TWRTGKDPEA IDFARQAISA GIYHIDTAQN YKNEAEAGTA
IRECGLPREK IFVTTKWSRL NGLDIATSFE NSLKDLNVSY IDLYLIHGAE LCDDIPACWK
EMEKIKDSGL TKSIGVSNFE VADLEQLFSV ARYIPTVNQI LFHPYVYEES VPIFNLCKQR
GIVVQAYSPL IPITKQPGGP LDRPIGAIVE RLGASTDQVL LAWAKSKDTA PVTNSKKKER
LEGYVRAGDL ALTPEDINAI DTGPEKVLSQ VVKKVKQDEL SVVCSVETAA ANLAQSGGMI
GGLIYEDELE TTTDTLIMLA NNPSLISLKA LKPFKTAVHD YWRRHVDALV LLAEMAIREQ
VPKLGALQRW VRECDAVLSP KMSKQEENRV WQVLDAILRT TQPEMIAQAS ASDEGALEAG
SRLRWYTPFT VDPGLSSRKV HIDSDSISSS AAKVLVPLQT TPGPERRPPN KHPAVIYFSP
DNTFPLLPSS ERTRQPTRHE LPGVPGAFII NDALEVPECE ALVKAAEAVG LIPDEPIGGS
ATQLSSVLAH NLIWLADTTF IRTLYQRLVH LLPQTVHGGA VKGINSRFRL YRYRPGALYR
PHIDGAWPSS ALNSTTNPPT YVYDSDPTVY SRLTFLIYLN DDFDGGCTTF FLPSVTQGIL
EARPVKPRTG TVCVFPHGAA KGSLLHEGSG VVSGAKYVIR TEVLQRDTRP RVSTSPAIVL
SSRSKAFGTW KIPLGDTTIN QVDQAISVGF SHIGAFDPPL HLLSKSKFVS THAQLGFVDT
AQSYRNEAEA GKAILESGLA RDDIFITTKF SGVDGLDIET SIKNSLKNLG VKHIDLYLIH
HPRLAVPDIP TAWRQMEGLK DAGLVKSIGI SNFEIEHIET LLSSAKVTPA VNQIILHPYV
YKRQAPLLEY LNKKGIVFEA YSPLIPVTQY PGGPVDKPVK AAGKRLGATD DQVLLAWAKV
KGAVVLTSSS KKERLEGYLQ AGDLVLTDDE VKAIDEAGAQ GTKILTARTV VRRTAAVLFA
GAVGLGICSY LGINVL
//