ID   A0A409XE42_PSICY        Unreviewed;      1614 AA.
AC   A0A409XE42;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 11.
DE   RecName: Full=Carboxylesterase type B domain-containing protein {ECO:0000259|Pfam:PF00135};
GN   ORFNames=CVT25_005100 {ECO:0000313|EMBL:PPQ89001.1};
OS   Psilocybe cyanescens.
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Agaricomycetidae; Agaricales; Agaricineae; Strophariaceae; Psilocybe.
OX   NCBI_TaxID=93625 {ECO:0000313|EMBL:PPQ89001.1, ECO:0000313|Proteomes:UP000283269};
RN   [1] {ECO:0000313|EMBL:PPQ89001.1, ECO:0000313|Proteomes:UP000283269}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2631 {ECO:0000313|EMBL:PPQ89001.1,
RC   ECO:0000313|Proteomes:UP000283269};
RX   PubMed=30283667; DOI=10.1002/evl3.42;
RA   Reynolds H.T., Vijayakumar V., Gluck-Thaler E., Korotkin H.B.,
RA   Matheny P.B., Slot J.C.;
RT   "Horizontal gene cluster transfer increased hallucinogenic mushroom
RT   diversity.";
RL   Evol. Lett. 2:88-101(2018).
CC   -!- SIMILARITY: Belongs to the type-B carboxylesterase/lipase family.
CC       {ECO:0000256|ARBA:ARBA00005964}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PPQ89001.1}.
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DR   EMBL; NHYD01001970; PPQ89001.1; -; Genomic_DNA.
DR   STRING; 93625.A0A409XE42; -.
DR   InParanoid; A0A409XE42; -.
DR   OrthoDB; 1743223at2759; -.
DR   Proteomes; UP000283269; Unassembled WGS sequence.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 4.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR002018; CarbesteraseB.
DR   InterPro; IPR019826; Carboxylesterase_B_AS.
DR   PANTHER; PTHR11559; CARBOXYLESTERASE; 1.
DR   PANTHER; PTHR11559:SF423; CARBOXYLIC ESTER HYDROLASE; 1.
DR   Pfam; PF00135; COesterase; 4.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 3.
DR   PROSITE; PS00122; CARBOXYLESTERASE_B_1; 3.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000283269};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           24..1614
FT                   /note="Carboxylesterase type B domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5019179448"
FT   DOMAIN          33..354
FT                   /note="Carboxylesterase type B"
FT                   /evidence="ECO:0000259|Pfam:PF00135"
FT   DOMAIN          684..1001
FT                   /note="Carboxylesterase type B"
FT                   /evidence="ECO:0000259|Pfam:PF00135"
FT   DOMAIN          1018..1137
FT                   /note="Carboxylesterase type B"
FT                   /evidence="ECO:0000259|Pfam:PF00135"
FT   DOMAIN          1162..1365
FT                   /note="Carboxylesterase type B"
FT                   /evidence="ECO:0000259|Pfam:PF00135"
SQ   SEQUENCE   1614 AA;  173339 MW;  CB052FBE7E8FF587 CRC64;
     MKYFENFALL LALVVSNCHV MGADPATDSN NGLVVNTQQG SVSGVLFTSK VRQFLGVPYA
     SAQRWEAPTL PPNRTSVLKA TNFSATCPQN MAASNMEFLK LSGGQGIGIP ESEDCLTANI
     WVPSINRKQQ TAVLIWIYGG GFQWGSSNLP IYNGQNFVRD NDDITIVTFN YRLNIFGQPN
     APQLLSKTKT QNFGLLDIDA AIQWVHANIG AFGGDPDRIS LFGQSAGSMA VDAYTFLHPN
     DTIVKGTIQQ SGTLIQGDSP GGLANTTYEG DIWNNLASSL NCGSNPDDAQ LSCMKAVPFR
     TLEDAVMKFG GIVFKLFIDD ITLFTDVPAR AASGNFLKVP LLSGSVLNEN DIFEVAAELT
     TPPGIVLPFV TEVVADLQTQ VAFTCPAGSN AQDRLNAQVP AWRYQYQAVF ADLSTRTELR
     SYHQAEVPIV FGTYDTVIPS VKSTATEVAL SKYMQNAYDR KISPKRYRLC AEVPFAGTIQ
     QSGNLHLTSA DVLATPTIDD STWITPDDAQ LSCMKAILFR TLEDEVIKTG AIVFKLLTDS
     MLPSWAPDQV IINIDSLNSN RYHQEISTCC THITAGYFLK VPVLGESTLN EADLLIVAAA
     LISPPGEVVL FVGKVVSDIQ TQTNFTCPAA TVAQDRVNIK VLIPISRADS ASIDYSSSNL
     AMRLSLVLLS TLLLSAYADV PGLTVQTQQG LVAGSLVVPT VRQFLGVPFA SAERWQAPRL
     PATRKGVFQA TKFGDSCIQE LSPPNVEFLV LAGVQGINVT SSEDCMSVNI WAPSVERKQK
     TAVMIWIYGG SFLFGTKSNI SIYNGQNFVR DNDDLTIVTF NYRINIFGQP NAPQLGAQNV
     NFGLLDIDAA VQWVHANIAN FGGDPNRIVL FGQSAGAAAT DAYTFAHPED TIVLSKNLEG
     NISGSSVISG ASTAANQSAW NTVAAAVGCG AAPTAQQFIC MQKTQANTLE SAVVSTGAAF
     SLVVDNTTLF ADTETRAANG HFLHVPLLGG TTANEDDIFI VDQELLAAGI AIPSVTEMLS
     DVETLLGFTC PAGVTALHRI NANVPTWRYQ HQGNAVFPDI STRPDLRAYH ASEIPLVFGT
     YNVSTIPATP VEIALSRYIQ SAWVAFARNP AQGLLNFGWP MYNPNTTSLA QLGNAANQTG
     VVFTQGNLID FACASAQNAG LTVSTQQGPV AGTLVLPTVR RFLGVPFATA KRWQAPEHPT
     ARKDVFQATK FSDVCFQELS PFNVGYLVLA QQQQGINATS SEDCLSVNIW SPSINRKQKT
     AVMVWIYGGG FTFGSSNLPL YDGQNFVRDN DDVTIVTFNY RLNIFGQPNA PQLGAKNVNF
     GLLDIDAAVQ WVHANIANFG GDPNRIVLFG QSAGAAAADA YTFAHPHDTI VKASTPQQFS
     CMQRVPAATL AKAVVSTGAG FSLVIDGVTV FEDTATRAAN GNFLQVPLLG GTTANEIDVF
     QVDTELITIG FVPPVLTELI SDISTLLEFT CSAGVAAVVR INANVPTWRY QLQAIFPDLT
     TRPELRAYHS TEIPLVFGTY NSSSTGIPAT PTEIALSRYM QSAWVAFARD PARGLLNFGW
     PLYNPNTTSL AQLGNSANQT GVVFTQGNLV DFACTNAAAL TDIENQLSAM LFGG
//