ID A0A409XJ27_PSICY Unreviewed; 538 AA.
AC A0A409XJ27;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE RecName: Full=FAD-binding domain-containing protein {ECO:0000259|Pfam:PF01494};
DE Flags: Fragment;
GN ORFNames=CVT25_010138 {ECO:0000313|EMBL:PPQ90749.1};
OS Psilocybe cyanescens.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Strophariaceae; Psilocybe.
OX NCBI_TaxID=93625 {ECO:0000313|EMBL:PPQ90749.1, ECO:0000313|Proteomes:UP000283269};
RN [1] {ECO:0000313|EMBL:PPQ90749.1, ECO:0000313|Proteomes:UP000283269}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2631 {ECO:0000313|EMBL:PPQ90749.1,
RC ECO:0000313|Proteomes:UP000283269};
RX PubMed=30283667; DOI=10.1002/evl3.42;
RA Reynolds H.T., Vijayakumar V., Gluck-Thaler E., Korotkin H.B.,
RA Matheny P.B., Slot J.C.;
RT "Horizontal gene cluster transfer increased hallucinogenic mushroom
RT diversity.";
RL Evol. Lett. 2:88-101(2018).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- SIMILARITY: Belongs to the UbiH/COQ6 family.
CC {ECO:0000256|ARBA:ARBA00005349}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PPQ90749.1}.
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DR EMBL; NHYD01001548; PPQ90749.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A409XJ27; -.
DR STRING; 93625.A0A409XJ27; -.
DR InParanoid; A0A409XJ27; -.
DR OrthoDB; 5473786at2759; -.
DR Proteomes; UP000283269; Unassembled WGS sequence.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-KW.
DR GO; GO:0008681; F:2-octaprenyl-6-methoxyphenol hydroxylase activity; IEA:InterPro.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0016709; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen; IEA:InterPro.
DR GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR HAMAP; MF_03193; COQ6_monooxygenase; 1.
DR InterPro; IPR002938; FAD-bd.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR018168; Ubi_Hdrlase_CS.
DR InterPro; IPR010971; UbiH/COQ6.
DR InterPro; IPR000689; UbQ_mOase_COQ6.
DR NCBIfam; TIGR01988; Ubi-OHases; 1.
DR PANTHER; PTHR43876; UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43876:SF7; UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL; 1.
DR Pfam; PF01494; FAD_binding_3; 2.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR PROSITE; PS01304; UBIH; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Membrane {ECO:0000256|ARBA:ARBA00022792};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00022792};
KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792};
KW Monooxygenase {ECO:0000256|ARBA:ARBA00023033};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000283269};
KW Ubiquinone biosynthesis {ECO:0000256|ARBA:ARBA00022688}.
FT DOMAIN 72..294
FT /note="FAD-binding"
FT /evidence="ECO:0000259|Pfam:PF01494"
FT DOMAIN 365..434
FT /note="FAD-binding"
FT /evidence="ECO:0000259|Pfam:PF01494"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:PPQ90749.1"
SQ SEQUENCE 538 AA; 57752 MW; BD200E85380C8F4F CRC64;
WAGGTRSGER IRYVRPAASG LLETDISIGS SSFVRKNISV TLIEGGDLTK IKSWNPSPES
FSNRVSSLTN ASQSFLQETG SWSYIDETRT SEVEQLQVWD GISDARIEFS SADIPSTSSM
ARLTENLNLQ RGLLRHLDNI PEVQILQKTR VTAIENDTSE RGGWPLLHLD NDTTLRARLL
IGADGFNSPV RTFAQISSFG WAYDTQAIVA TLNHSARGAY EGPNTTAYQR FLPTGPIAFL
PLSPSVSSLV WSTKPSIAAA LLASNPDVLT NMINAAFRLP DVSLKYLQKR VVDAHAAGTP
ISPSEIREEI QWREEAHGID RNSAYSSALL GVGSQGIPPA DSEMLPPLVV ELQPGTMASF
PLRFNHAESY AGEGFGARTV LVGDAAHTIH PLAGQGLNLG LADVECLTRC IKNSLLSGGD
IGSYTALLPY TQERYLANHT VMSACDKLHK LYSIENQQIV WARSVGVEVL NELDTVKAAI
MMTAGANKAV GRSTGHSTAY TLAGNAVESL ASAVHTAGAI GGIFGNYVNS VVGKLAKK
//
