ID A0A409XVZ6_PSICY Unreviewed; 1304 AA.
AC A0A409XVZ6;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 13-SEP-2023, entry version 18.
DE RecName: Full=Urea carboxylase {ECO:0008006|Google:ProtNLM};
GN ORFNames=CVT25_004411 {ECO:0000313|EMBL:PPQ94925.1};
OS Psilocybe cyanescens.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Strophariaceae; Psilocybe.
OX NCBI_TaxID=93625 {ECO:0000313|EMBL:PPQ94925.1, ECO:0000313|Proteomes:UP000283269};
RN [1] {ECO:0000313|EMBL:PPQ94925.1, ECO:0000313|Proteomes:UP000283269}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2631 {ECO:0000313|EMBL:PPQ94925.1,
RC ECO:0000313|Proteomes:UP000283269};
RX PubMed=30283667; DOI=10.1002/evl3.42;
RA Reynolds H.T., Vijayakumar V., Gluck-Thaler E., Korotkin H.B.,
RA Matheny P.B., Slot J.C.;
RT "Horizontal gene cluster transfer increased hallucinogenic mushroom
RT diversity.";
RL Evol. Lett. 2:88-101(2018).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PPQ94925.1}.
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DR EMBL; NHYD01000192; PPQ94925.1; -; Genomic_DNA.
DR STRING; 93625.A0A409XVZ6; -.
DR InParanoid; A0A409XVZ6; -.
DR OrthoDB; 313213at2759; -.
DR Proteomes; UP000283269; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR CDD; cd06850; biotinyl_domain; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 3.30.1360.40; -; 1.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR Gene3D; 2.40.100.10; Cyclophilin-like; 2.
DR InterPro; IPR011761; ATP-grasp.
DR InterPro; IPR005481; BC-like_N.
DR InterPro; IPR011764; Biotin_carboxylation_dom.
DR InterPro; IPR005482; Biotin_COase_C.
DR InterPro; IPR005479; CbamoylP_synth_lsu-like_ATP-bd.
DR InterPro; IPR003778; CT_A_B.
DR InterPro; IPR003833; CT_C_D.
DR InterPro; IPR029000; Cyclophilin-like_dom_sf.
DR InterPro; IPR016185; PreATP-grasp_dom_sf.
DR InterPro; IPR011054; Rudment_hybrid_motif.
DR InterPro; IPR011053; Single_hybrid_motif.
DR PANTHER; PTHR18866; CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE; 1.
DR PANTHER; PTHR18866:SF33; METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF02785; Biotin_carb_C; 1.
DR Pfam; PF00289; Biotin_carb_N; 1.
DR Pfam; PF02786; CPSase_L_D2; 1.
DR Pfam; PF02626; CT_A_B; 1.
DR Pfam; PF02682; CT_C_D; 1.
DR SMART; SM00796; AHS1; 1.
DR SMART; SM00797; AHS2; 1.
DR SMART; SM00878; Biotin_carb_C; 1.
DR SUPFAM; SSF50891; Cyclophilin-like; 2.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR SUPFAM; SSF160467; PH0987 N-terminal domain-like; 1.
DR SUPFAM; SSF52440; PreATP-grasp domain; 1.
DR SUPFAM; SSF51246; Rudiment single hybrid motif; 1.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
DR PROSITE; PS50975; ATP_GRASP; 1.
DR PROSITE; PS50979; BC; 1.
DR PROSITE; PS00866; CPSASE_1; 1.
DR PROSITE; PS00867; CPSASE_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Biotin {ECO:0000256|ARBA:ARBA00023267};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Reference proteome {ECO:0000313|Proteomes:UP000283269}.
FT DOMAIN 5..482
FT /note="Biotin carboxylation"
FT /evidence="ECO:0000259|PROSITE:PS50979"
FT DOMAIN 131..332
FT /note="ATP-grasp"
FT /evidence="ECO:0000259|PROSITE:PS50975"
SQ SEQUENCE 1304 AA; 144027 MW; F7D9C0F9D93BC198 CRC64;
MGIYDNHKLL IANRGEIAVR ILRTAKRIGL QTVAIYTPSD ALSPHVLQAN ESVPLKLPES
TSTASSEAAA YLSISTIIDI CKTHSVTLVH PGYGFLSENA DFAAQVVENG MVWLGPRHEV
IRWMGMKHEA RKIAQEAGIR VVPGSDGLVA SEQEALEAAS RCGFPVMLKA TAGGGGMGMV
VCHDGESLVK NFRFTEGRAQ ALFHNNGIYL ERYYEAARHI EIQIFGNGQG SVIHLREREC
SVQRRHQKVI EESPSPFCVS HPGLRERMCD VAVSLARAIK YNSAGTIEFL VDEETVNFYF
LEMNTRIQVE HPVTEQIHPG LDLVELMIKQ GLEELSPNKG LLSTSPEMAQ ATYDQLHEQG
LRQGYAHSIE GRIYAENPYD GFIPSPGLLQ HVSTDIVGHD WLRIDSWVET GMTITPHFDP
LLAKVIVSGA SREEALSRFL MALGEVKILG PPNNIGYLAS IAENEQFRAG LVTTRFLETF
KVHPSAFKVL SSGIDTTIQD LPGRHLKLGI PVSGPMDSLA FATANILVGN PKTTEGLEIV
VVPGVKASFY FFVQTVLAVT GKDVTITVNN ERRLMWSKII VPPFSTVDIE AKPTSVTAGF
RVYVCIRGGF PDVPPYLGSK STSMGLGGYQ GRSLIKGDLI SIENCSSASD EENAPCIPEL
LTPSYPSHWV IYVLPGPHGD DEFITADGIQ RFYSTHWRIS PSSNRLGIRL DAPTSTEKIE
WARDSGGEGG SHPSNILDNG YAPGTINING DTPVILTNEG PDMGGYLCIC TVATAEMWKL
GQLAPGCTVQ FRRISWIAAL QRLVLNSQWL ETIEKFVSRT IEESPTVNFN LLNTETKDMA
FFGVLHEQKG HEGYPSRLRI TFRQAGDSAI LVEFGEMHLD IFIRARIHAF QGIVNEKNVL
GVLSVCPCIR SILVGCPILI DGCKADIINF HYDPDIISQH AFLRILVESA ALIPDNMDEM
TFSGRRITFP IVLDDRWSKE AIQRYMSTAR DKAVYLPSNV EYLANNNGLA NAKEALQKLI
ASDWLVLGVG FYLACPFLIP IDPRCRLIGQ KMNPSRTFTP RGAIGIAGPV AAIYPIESPG
GYQLYGRTLP TWQTWGKGHD FRADKPWLLE AFDQVTPPFT TYHSFHFLSL LQITFKPVSE
DEYVKIENEF DAGQYVFQIE SAQFSVRNHA QFLQSIGEEL QMFSTRQAEA SKREELKERV
LLREWEETKT LLNTDNNGKG SIYNDTENGV RITAPLFANI WKLRCSANDI IESESQVLVV
LEAMKTEIPV CAGEGNKGKS IIGFGKGVQE GHSVCPGDTL IILG
//
