ID   A0A409Y3E3_9AGAR        Unreviewed;       824 AA.
AC   A0A409Y3E3;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE            EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
DE   Flags: Fragment;
GN   ORFNames=CVT26_002819 {ECO:0000313|EMBL:PPQ97471.1};
OS   Gymnopilus dilepis.
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Agaricomycetidae; Agaricales; Agaricineae; Hymenogastraceae; Gymnopilus.
OX   NCBI_TaxID=231916 {ECO:0000313|EMBL:PPQ97471.1, ECO:0000313|Proteomes:UP000284706};
RN   [1] {ECO:0000313|EMBL:PPQ97471.1, ECO:0000313|Proteomes:UP000284706}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SRW20 {ECO:0000313|EMBL:PPQ97471.1,
RC   ECO:0000313|Proteomes:UP000284706};
RX   PubMed=30283667; DOI=10.1002/evl3.42;
RA   Reynolds H.T., Vijayakumar V., Gluck-Thaler E., Korotkin H.B.,
RA   Matheny P.B., Slot J.C.;
RT   "Horizontal gene cluster transfer increased hallucinogenic mushroom
RT   diversity.";
RL   Evol. Lett. 2:88-101(2018).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PPQ97471.1}.
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DR   EMBL; NHYE01001246; PPQ97471.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A409Y3E3; -.
DR   STRING; 231916.A0A409Y3E3; -.
DR   InParanoid; A0A409Y3E3; -.
DR   OrthoDB; 1386at2759; -.
DR   Proteomes; UP000284706; Unassembled WGS sequence.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR   GO; GO:0000209; P:protein polyubiquitination; IEA:InterPro.
DR   CDD; cd00078; HECTc; 1.
DR   Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR   InterPro; IPR044611; E3A/B/C-like.
DR   InterPro; IPR000569; HECT_dom.
DR   InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR   PANTHER; PTHR45700; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR   PANTHER; PTHR45700:SF2; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR   Pfam; PF00632; HECT; 1.
DR   SMART; SM00119; HECTc; 1.
DR   SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR   PROSITE; PS50237; HECT; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000284706};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW   ECO:0000256|PROSITE-ProRule:PRU00104}.
FT   DOMAIN          482..824
FT                   /note="HECT"
FT                   /evidence="ECO:0000259|PROSITE:PS50237"
FT   REGION          89..115
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          369..401
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        96..110
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        384..400
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        792
FT                   /note="Glycyl thioester intermediate"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:PPQ97471.1"
SQ   SEQUENCE   824 AA;  92518 MW;  4F4A796607C2BCBA CRC64;
     LPNRLPLTHL PAFLSKLPLL SLELIEPHIP GILQQTGIEA KVHLAATLYM FMSPHYKKLS
     APAFAAYLRL SIGLIGAFPR ELFKEKARAA KGAKTKSGKS TPSRSTPNGA AYDSDPEPRV
     MVVSHFSQPT TPAPLPQIDD KTLTRLSKLV SAAHLTPLIS ATQAKASLFP ELIRYLFTLT
     LVWPEDKQGE ILNVILASAG QGGGLVREVY RVLVRRSGLG KEGQGGVMDP ANFSQYPPLL
     FLSDLYSQAL LTMGDDEFFG TAPSGPQTRA PRNPLSLDEL VEFSKQLLNI AFTLYWRDGQ
     GTGHGEGNYV SDELRCSWDV VREKVTRCLV GIHARDSRRP FVPPDHWLIT SQLDMQSFVE
     AAILEEQQLS QDQDEAPSPP PSTHPIHHHH RSHHPRHTLS KRQIASLSPR LGILNNIPFC
     IPFEVRVSIF RHFVLNDMMK HASETDRGGM GALRRSGFGY GLRPRVQVRR GMVAQDGFDK
     LAEADLKAPF GEEELVLGTL CADVILFRAG IDGGGVFKEF FTSLCKEVFD TDRGLWLATK
     NNELYPNPHA YATEPHSLNW YRFIGRILGK AMYEGILVDV AFAGFFLAKW LGRQNFLDDL
     ASLDPELYNG LIFLKHYTGN VEDLSLNFTI SIEEFGVTKT VDLIKNGSNI AVTKENRLQY
     IYLVSHYRLT KQIKLQSEAF FEGLSEMIDP KWLRMFNRQE VQVLIGGVNS PIDMDDLRQH
     TNYGGLYDDN HETIEMFWRV VNSFNQEQRR ALLRFVTSCS RPPLLGFKEL VPNFSIRDAG
     SDQYRLPTSS TCVNLLKLPR YTNEKTLRDK LLQAINSNAG FDLS
//