ID A0A409Y8C0_9AGAR Unreviewed; 1210 AA.
AC A0A409Y8C0;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE RecName: Full=XPG-I domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=CVT24_009350 {ECO:0000313|EMBL:PPQ99161.1};
OS Panaeolus cyanescens.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Galeropsidaceae; Panaeolus.
OX NCBI_TaxID=181874 {ECO:0000313|EMBL:PPQ99161.1, ECO:0000313|Proteomes:UP000284842};
RN [1] {ECO:0000313|EMBL:PPQ99161.1, ECO:0000313|Proteomes:UP000284842}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2629 {ECO:0000313|EMBL:PPQ99161.1,
RC ECO:0000313|Proteomes:UP000284842};
RX PubMed=30283667; DOI=10.1002/evl3.42;
RA Reynolds H.T., Vijayakumar V., Gluck-Thaler E., Korotkin H.B.,
RA Matheny P.B., Slot J.C.;
RT "Horizontal gene cluster transfer increased hallucinogenic mushroom
RT diversity.";
RL Evol. Lett. 2:88-101(2018).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.
CC {ECO:0000256|ARBA:ARBA00005283}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PPQ99161.1}.
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DR EMBL; NHTK01001368; PPQ99161.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A409Y8C0; -.
DR STRING; 181874.A0A409Y8C0; -.
DR InParanoid; A0A409Y8C0; -.
DR OrthoDB; 5479162at2759; -.
DR Proteomes; UP000284842; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004519; F:endonuclease activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR CDD; cd09904; H3TH_XPG; 1.
DR CDD; cd09868; PIN_XPG_RAD2; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 2.
DR InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR InterPro; IPR008918; HhH2.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR006086; XPG-I_dom.
DR InterPro; IPR006084; XPG/Rad2.
DR InterPro; IPR001044; XPG/Rad2_eukaryotes.
DR InterPro; IPR019974; XPG_CS.
DR InterPro; IPR006085; XPG_DNA_repair_N.
DR PANTHER; PTHR16171:SF7; DNA EXCISION REPAIR PROTEIN ERCC-5; 1.
DR PANTHER; PTHR16171; DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED; 1.
DR Pfam; PF00867; XPG_I; 1.
DR Pfam; PF00752; XPG_N; 1.
DR PRINTS; PR00853; XPGRADSUPER.
DR PRINTS; PR00066; XRODRMPGMNTG.
DR SMART; SM00279; HhH2; 1.
DR SMART; SM00484; XPGI; 1.
DR SMART; SM00485; XPGN; 1.
DR SUPFAM; SSF47807; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR SUPFAM; SSF88723; PIN domain-like; 1.
DR PROSITE; PS00841; XPG_1; 1.
DR PROSITE; PS00842; XPG_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000284842}.
FT DOMAIN 1..57
FT /note="XPG N-terminal"
FT /evidence="ECO:0000259|SMART:SM00485"
FT DOMAIN 811..880
FT /note="XPG-I"
FT /evidence="ECO:0000259|SMART:SM00484"
FT REGION 113..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 351..387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 415..434
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 450..515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 588..633
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 657..737
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1064..1210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 770..801
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 122..138
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 354..382
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 593..630
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 678..704
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 718..732
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1143..1157
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1210 AA; 133771 MW; 8B2A5D7F8466409E CRC64;
MRDKEGRGLV NAHVLGFLRR IAKLLFYGIK PVFVFDGGAP ALKRATLNER KKKKAGAALN
HAQLAEKILA AKLRREAIQH ASGSKNSGKQ KANDVPLDDS TVYLEDIDHS RSKTPKKAKA
VHVPSSSEKK KTFHDHDPYN LPDVDLEAAV SQRTQVAATA DPRLATEDEL HAFLASITPE
DLDITSPEFH TLPTSIQYEI IGDLRLKSRQ TSHARLQKML RSSQTPLDFS KAQIAHLKER
NQLTQRLLMT TDSIGSAHIA IPVRIASERN REYVLVKNGG MEGGWILGIR DLRGTEEQPI
VLDHGDGGNQ PIKPNEIVED DSDADMEEVP IADPDLLAYQ REMALDGIAK RSGSNRRTIP
TSMFLDDTNS NDLSSSGTQG KSQHIQDDDD DDVALAIQQS MEHAKATQLS LEVKSKEVAE
TGPEETVDDD DDIYVPYSDF TPLGTALSFA NASSRPHSSP SKSFGPGATT TSSSPAAQVP
TQSTSMFSFK GTGLLGTRNE TNTDNPRSNT QVVDSATHRE QQEMDTLLTQ TNRLFQEHES
DSSDDMEEVP FPVPASTTFT MTSTVDQKRE AVSIDSDDSN DDMEEVTIES PMHPQQIPVS
STKSGSEHPS FSNDTQLDLG GTSPSGVTES GMTFADPGLE AIEISVPIIR KSLPALHQHG
QKGTGVTDDH PQPLPAPAFK NTSISKNLTS GASTDVPSTL QHSESNKGEE SDQDEELIPW
SRSPSPQRGA QGDQVETADH AAWDAAEEMD LHAEEGEFAM FLSQVKGKTL ESIQQEIDDE
LQKLNQQRRA AMRDAEDVTQ QMITQIMIML RLFGIPYITA PMEAEAQCAE LVSLGLVDGV
ITDDSDVFLF GAQRVYKNMF NQSKTVECFL SSDLSRELGL TRDTLIQLAY LLGSDYTEGL
PGVGPVVAME LLKEFPGRDG LFRFRDWWLA VQSGKDNDHG QSTFRRRFKK RFKDLYLTSD
WPNTAVRDAY YHPTVDSSEE PFKWGLPDLD GLHQFLHQEL GWQQDKVDEL LLPIIQKMNK
RREAAAANQQ GVLNEFLDIS GSGTHAPRQR QAYASKRLQQ VISDFRKRQN RGSVSPGSDE
NMVEEHPDSV PKPATKKRRR KSPTPKSSDS APSKKPKKPR ATKSKKRRVS PDPLDDSSSY
SDTEDYEANA TRNTQAENPL EADRRVALNL RPRPKPRPTY KGSVHQGGDE EAQPPTMRAS
SPDVIEQPQL
//
