ID A0A409Y8P5_9AGAR Unreviewed; 653 AA.
AC A0A409Y8P5;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 13.
DE RecName: Full=uroporphyrinogen-III synthase {ECO:0000256|ARBA:ARBA00013109};
DE EC=4.2.1.75 {ECO:0000256|ARBA:ARBA00013109};
DE AltName: Full=Hydroxymethylbilane hydrolyase [cyclizing] {ECO:0000256|ARBA:ARBA00032649};
DE AltName: Full=Uroporphyrinogen-III cosynthase {ECO:0000256|ARBA:ARBA00031702};
GN ORFNames=CVT24_009186 {ECO:0000313|EMBL:PPQ99318.1};
OS Panaeolus cyanescens.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Galeropsidaceae; Panaeolus.
OX NCBI_TaxID=181874 {ECO:0000313|EMBL:PPQ99318.1, ECO:0000313|Proteomes:UP000284842};
RN [1] {ECO:0000313|EMBL:PPQ99318.1, ECO:0000313|Proteomes:UP000284842}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2629 {ECO:0000313|EMBL:PPQ99318.1,
RC ECO:0000313|Proteomes:UP000284842};
RX PubMed=30283667; DOI=10.1002/evl3.42;
RA Reynolds H.T., Vijayakumar V., Gluck-Thaler E., Korotkin H.B.,
RA Matheny P.B., Slot J.C.;
RT "Horizontal gene cluster transfer increased hallucinogenic mushroom
RT diversity.";
RL Evol. Lett. 2:88-101(2018).
CC -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX
CC biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.
CC {ECO:0000256|ARBA:ARBA00004772}.
CC -!- SIMILARITY: Belongs to the uroporphyrinogen-III synthase family.
CC {ECO:0000256|ARBA:ARBA00008133}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PPQ99318.1}.
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DR EMBL; NHTK01001363; PPQ99318.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A409Y8P5; -.
DR STRING; 181874.A0A409Y8P5; -.
DR InParanoid; A0A409Y8P5; -.
DR OrthoDB; 1411521at2759; -.
DR UniPathway; UPA00251; UER00320.
DR Proteomes; UP000284842; Unassembled WGS sequence.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006780; P:uroporphyrinogen III biosynthetic process; IEA:InterPro.
DR CDD; cd06578; HemD; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR039793; UROS/Hem4.
DR PANTHER; PTHR12390; UROPORPHYRINOGEN III SYNTHASE; 1.
DR PANTHER; PTHR12390:SF0; UROPORPHYRINOGEN-III SYNTHASE; 1.
DR Pfam; PF02602; HEM4; 1.
DR SUPFAM; SSF69618; HemD-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000284842}.
FT DOMAIN 17..275
FT /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT synthase"
FT /evidence="ECO:0000259|Pfam:PF02602"
SQ SEQUENCE 653 AA; 73025 MW; 26011755780E7675 CRC64;
MNVLLLREPS EDGPDLYETA FKTAGYNPVS LPVLETVFEN LSTLSLIIRQ GPMNRGVHGV
VITSKRSCEA WGEAQTDMPL DLRERWTRIP FYVVGEGTAS ALQHAFKGNT DDDLVLDIRG
QHSGNAATLA PFILEDISQR PATLLYLSGD KNRDTIPRLL KQGGITLDTI QVYKTQGSSS
FGEALSKKVA RYSKGNEPWW IACFAPSSTL FAFPSLQNHF SLRDLGKEAP GENQGDLIIA
RIAAIGPTTK SCLEDDLSVH VDVMAPHPTP EALLEVIHAY ESGMLDRKYF CVNVSSQTAY
YMRASSVCSA CNFKDAFIPE IIHILTKMLP TEILHEIFLG VVGYDNQKSR LLPLLQTCRV
FYSVARRILY YDLVFNSPGQ IARFAVTHGN TKGPTIYPRT ITVDISLDLE HTTFTELYNL
FSTCFKQSSS STKRDKDQDG MAEEEELPLD DKGRILLDSL SLRLNSHTFD PNLNMIYESL
VLVNPRRFEW TGRDPPHHFS IAIVPRAIPH LFNALSSYTN LAQLKLSHLS FLSAIFPEIP
SLEIVHIGQA TNLDPLNVAY IVCSPNMQKI TQIRIVDAYK GSIWGLRLRR SDIEKAVLGE
LSFISNPRIK KQLDDPHEEE RAAAAERIRG IVTCEAQNER IMGGDRAETR VLL
//
